Detalhe da pesquisa
1.
Points to consider regarding the use and implementation of virtual controls in nonclinical general toxicology studies.
Regul Toxicol Pharmacol
; 150: 105632, 2024 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-38679316
2.
Development of BET inhibitors as potential treatments for cancer: A search for structural diversity.
Bioorg Med Chem Lett
; 44: 128108, 2021 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33991625
3.
Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.
Bioorg Med Chem Lett
; 51: 128376, 2021 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34560263
4.
BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.
Bioorg Med Chem Lett
; 25(9): 1905-9, 2015 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25857941
5.
Cytochrome P450 11A1 bioactivation of a kinase inhibitor in rats: use of radioprofiling, modulation of metabolism, and adrenocortical cell lines to evaluate adrenal toxicity.
Chem Res Toxicol
; 25(3): 556-71, 2012 Mar 19.
Artigo
Inglês
| MEDLINE | ID: mdl-22295996
6.
Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties.
ACS Med Chem Lett
; 13(7): 1165-1171, 2022 Jul 14.
Artigo
Inglês
| MEDLINE | ID: mdl-35859878
7.
TGFß2 and TGFß3 mediate appropriate context-dependent phenotype of rat valvular interstitial cells.
iScience
; 24(3): 102133, 2021 Mar 19.
Artigo
Inglês
| MEDLINE | ID: mdl-33665554
8.
Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.
J Med Chem
; 64(19): 14247-14265, 2021 10 14.
Artigo
Inglês
| MEDLINE | ID: mdl-34543572
9.
Safety assessment considerations and strategies for targeted small molecule cancer therapeutics in drug discovery.
Toxicol Pathol
; 38(1): 165-8, 2010 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-19907054
10.
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).
J Med Chem
; 62(7): 3228-3250, 2019 04 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30893553
11.
Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor.
Cancer Res
; 65(9): 3781-7, 2005 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-15867374
12.
A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines.
J Leukoc Biol
; 102(5): 1271-1280, 2017 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28899907
13.
Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.
ACS Med Chem Lett
; 6(5): 523-7, 2015 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-26005526
14.
A bioanalytical strategy utilizing dried blood spot sampling and LC-MS/MS in discovery toxicology studies.
Bioanalysis
; 4(9): 1057-64, 2012 May.
Artigo
Inglês
| MEDLINE | ID: mdl-22612686
15.
The north american control animal database: a resource based on standardized nomenclature and diagnostic criteria.
Toxicol Pathol
; 30(1): 75-9, 2002.
Artigo
Inglês
| MEDLINE | ID: mdl-11890478