Detalhe da pesquisa
1.
The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.
Cell
; 154(5): 1100-1111, 2013 Aug 29.
Artigo
Inglês
| MEDLINE | ID: mdl-23993098
2.
"Domain gauges": A reference system for multivariate profiling of brain fMRI activation patterns induced by psychoactive drugs in rats.
Neuroimage
; 112: 70-85, 2015 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25724758
3.
Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.
J Pharmacol Exp Ther
; 353(1): 213-33, 2015 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-25665805
4.
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease.
Nat Rev Neurosci
; 11(8): 589-99, 2010 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-20631712
5.
Closing thoughts for cognitive enhancement.
Handb Exp Pharmacol
; 228: 451-9, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25977093
6.
Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.
J Neurosci
; 33(9): 3953-66, 2013 Feb 27.
Artigo
Inglês
| MEDLINE | ID: mdl-23447605
7.
TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity.
Proc Natl Acad Sci U S A
; 108(20): 8485-90, 2011 May 17.
Artigo
Inglês
| MEDLINE | ID: mdl-21525407
8.
The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system.
Proc Natl Acad Sci U S A
; 106(47): 20081-6, 2009 Nov 24.
Artigo
Inglês
| MEDLINE | ID: mdl-19892733
9.
CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor.
J Pharmacol Exp Ther
; 339(2): 474-86, 2011 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-21849627
10.
Mapping the binding pocket of dual antagonist almorexant to human orexin 1 and orexin 2 receptors: comparison with the selective OX1 antagonist SB-674042 and the selective OX2 antagonist N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA).
Mol Pharmacol
; 78(1): 81-93, 2010 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-20404073
11.
Preface to cognitive enhancement.
Handb Exp Pharmacol
; 228: v, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26317138
12.
Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists.
Mol Pharmacol
; 76(3): 618-31, 2009 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-19542319
13.
Me-talnetant and osanetant interact within overlapping but not identical binding pockets in the human tachykinin neurokinin 3 receptor transmembrane domains.
Mol Pharmacol
; 73(6): 1736-50, 2008 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-18308898
14.
Trace amine-associated receptor 1 modulates dopaminergic activity.
J Pharmacol Exp Ther
; 324(3): 948-56, 2008 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-18083911
15.
The acoustic startle reflex in Sprague-Dawley rats is altered by permanent middle cerebral artery occlusion.
Brain Res
; 1032(1-2): 44-9, 2005 Jan 25.
Artigo
Inglês
| MEDLINE | ID: mdl-15680940
16.
Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome.
Curr Opin Pharmacol
; 20: 124-34, 2015 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25488569
17.
Trace amine-associated receptor 1 activation silences GSK3ß signaling of TAAR1 and D2R heteromers.
Eur Neuropsychopharmacol
; 25(11): 2049-61, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-26372541
18.
Homer1/mGluR5 activity moderates vulnerability to chronic social stress.
Neuropsychopharmacology
; 40(5): 1222-33, 2015 Mar 13.
Artigo
Inglês
| MEDLINE | ID: mdl-25409593
19.
Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.
J Med Chem
; 58(3): 1358-71, 2015 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-25565255
20.
Comparative analysis of acute and chronic administration of haloperidol and clozapine using [3H] 2-deoxyglucose metabolic mapping.
Schizophr Res
; 61(2-3): 195-205, 2003 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-12729871