Pesquisa | Secretaria de Estado da Saúde

1.

Training pathologists to assess stromal tumour-infiltrating lymphocytes in breast cancer synergises efforts in clinical care and scientific research.

Ly, Amy; Garcia, Victor; Blenman, Kim R M; Ehinger, Anna; Elfer, Katherine; Hanna, Matthew G; Li, Xiaoxian; Peeters, Dieter J E; Birmingham, Ryan; Dudgeon, Sarah; Gardecki, Emma; Gupta, Rajarsi; Lennerz, Jochen; Pan, Tony; Saltz, Joel; Wharton, Keith A; Ehinger, Daniel; Acs, Balazs; Dequeker, Elisabeth M C; Salgado, Roberto; Gallas, Brandon D.

Histopathology ; 84(6): 915-923, 2024 May.

Artigo Inglês | MEDLINE | ID: mdl-38433289

2.

Deep resolution of clinical, cellular, and transcriptomic inflammatory markers during 52 weeks of IL-17A inhibition by secukinumab.

Tomalin, Lewis E; Kolbinger, Frank; Suprun, Maria; Wharton, Keith A; Hartmann, Nicole; Peters, Thomas; Glueck, Anton; Milutinovic, Marina; Krueger, James G; Suárez-Fariñas, Mayte.

Clin Exp Dermatol ; 2024 Jan 18.

Artigo Inglês | MEDLINE | ID: mdl-38240024

3.

IL-17A inhibition by secukinumab induces early clinical, histopathologic, and molecular resolution of psoriasis.

Krueger, James G; Wharton, Keith A; Schlitt, Thomas; Suprun, Maria; Torene, Rebecca I; Jiang, Xiaoyu; Wang, Claire Q; Fuentes-Duculan, Judilyn; Hartmann, Nicole; Peters, Thomas; Koroleva, Irina; Hillenbrand, Rainer; Letzkus, Martin; Yu, Xiaojing; Li, Yue; Glueck, Anton; Hasselberg, Anke; Flannery, Brian; Suárez-Fariñas, Mayte; Hueber, Wolfgang.

J Allergy Clin Immunol ; 144(3): 750-763, 2019 09.

Artigo Inglês | MEDLINE | ID: mdl-31129129

4.

Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length.

Chung, SeYeon; Vining, Melissa S; Bradley, Pamela L; Chan, Chih-Chiang; Wharton, Keith A; Andrew, Deborah J.

PLoS Genet ; 5(11): e1000746, 2009 Nov.

Artigo Inglês | MEDLINE | ID: mdl-19956736

5.

Molecular Characterization of Mesothelioma: Impact of Histologic Type and Site of Origin on Molecular Landscape.

Dagogo-Jack, Ibiayi; Madison, Russell W; Lennerz, Jochen K; Chen, Kuei-Ting; Hopkins, Julia F; Schrock, Alexa B; Ritterhouse, Lauren L; Lester, Ashley; Wharton, Keith A; Mino-Kenudson, Mari; Danziger, Natalie; Hung, Yin P; Mata, Douglas A; Ross, Jeffrey S.

JCO Precis Oncol ; 6: e2100422, 2022 06.

Artigo Inglês | MEDLINE | ID: mdl-35704798

6.

Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial.

Gerwin, Nicole; Scotti, Celeste; Halleux, Christine; Fornaro, Mara; Elliott, Jimmy; Zhang, Yunyu; Johnson, Kristen; Shi, Jian; Walter, Sandra; Li, Yufei; Jacobi, Carsten; Laplanche, Nelly; Belaud, Magali; Paul, Jochen; Glowacki, Gustavo; Peters, Thomas; Wharton, Keith A; Vostiar, Igor; Polus, Florine; Kramer, Ina; Guth, Sabine; Seroutou, Abdelkader; Choudhury, Subhajit; Laurent, Didier; Gimbel, Joseph; Goldhahn, Jörg; Schieker, Matthias; Brachat, Sophie; Roubenoff, Ronenn; Kneissel, Michaela.

Nat Med ; 28(12): 2633-2645, 2022 12.

Artigo Inglês | MEDLINE | ID: mdl-36456835

7.

The use of immunohistochemistry for biomarker assessment--can it compete with other technologies?

Dunstan, Robert W; Wharton, Keith A; Quigley, Catherine; Lowe, Amanda.

Toxicol Pathol ; 39(6): 988-1002, 2011 Oct.

Artigo Inglês | MEDLINE | ID: mdl-21971934

8.

Tissue Multiplex Analyte Detection in Anatomic Pathology - Pathways to Clinical Implementation.

Wharton, Keith A; Wood, Douglas; Manesse, Mael; Maclean, Kirsteen H; Leiss, Florian; Zuraw, Aleksandra.

Front Mol Biosci ; 8: 672531, 2021.

Artigo Inglês | MEDLINE | ID: mdl-34386519

9.

Immunohistochemical Validation of Rare Tissues and Antigens With Low Frequency of Occurrence: Recommendations From The Anatomic Pathology Patient Interest Association (APPIA).

Lott, Robert L; Riccelli, Peter V; Sheppard, Elizabeth A; Wharton, Keith A; Walk, Eric E; Kennedy, George; Portier, Bryce.

Appl Immunohistochem Mol Morphol ; 29(5): 327-334, 2021.

Artigo Inglês | MEDLINE | ID: mdl-32324630

10.

Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.

Zhang, Shu; Cagatay, Tolga; Amanai, Manami; Zhang, Mei; Kline, Janine; Castrillon, Diego H; Ashfaq, Raheela; Oz, Orhan K; Wharton, Keith A.

Mol Cell Biol ; 27(12): 4454-64, 2007 Jun.

Artigo Inglês | MEDLINE | ID: mdl-17438140

11.

Precise Identification of Cell and Tissue Features Important for Histopathologic Diagnosis by a Whole Slide Imaging System.

Bauer, Thomas W; Behling, Cynthia; Miller, Dylan V; Chang, Bernard S; Viktorova, Elena; Magari, Robert; Jensen, Perry E; Wharton, Keith A; Qiu, Jinsong.

J Pathol Inform ; 11: 3, 2020.

Artigo Inglês | MEDLINE | ID: mdl-32154040

12.

Digital Whole Slide Imaging Compared With Light Microscopy for Primary Diagnosis in Surgical Pathology.

Borowsky, Alexander D; Glassy, Eric F; Wallace, William Dean; Kallichanda, Nathash S; Behling, Cynthia A; Miller, Dylan V; Oswal, Hemlata N; Feddersen, Richard M; Bakhtar, Omid R; Mendoza, Arturo E; Molden, Daniel P; Saffer, Helene L; Wixom, Christopher R; Albro, James E; Cessna, Melissa H; Hall, Brian J; Lloyd, Isaac E; Bishop, John W; Darrow, Morgan A; Gui, Dorina; Jen, Kuang-Yu; Walby, Julie Ann S; Bauer, Stephen M; Cortez, Daniel A; Gandhi, Pranav; Rodgers, Melissa M; Rodriguez, Rafael A; Martin, David R; McConnell, Thomas G; Reynolds, Samuel J; Spigel, James H; Stepenaskie, Shelly A; Viktorova, Elena; Magari, Robert; Wharton, Keith A; Qiu, Jinsong; Bauer, Thomas W.

Arch Pathol Lab Med ; 144(10): 1245-1253, 2020 10 01.

Artigo Inglês | MEDLINE | ID: mdl-32057275

13.

Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.

Chan, Chih-Chiang; Zhang, Shu; Rousset, Raphaël; Wharton, Keith A.

Dev Biol ; 318(1): 17-28, 2008 Jun 01.

Artigo Inglês | MEDLINE | ID: mdl-18423435

14.

Cell-autonomous, myristyl-independent activity of the Drosophila Wnt/Wingless antagonist Naked cuticle (Nkd).

Chan, Chih-Chiang; Zhang, Shu; Cagatay, Tolga; Wharton, Keith A.

Dev Biol ; 311(2): 538-53, 2007 Nov 15.

Artigo Inglês | MEDLINE | ID: mdl-17942091

15.

An unconventional nuclear localization motif is crucial for function of the Drosophila Wnt/wingless antagonist Naked cuticle.

Waldrop, Sharon; Chan, Chih-Chiang; Cagatay, Tolga; Zhang, Shu; Rousset, Raphaël; Mack, Judy; Zeng, Wenlin; Fish, Matt; Zhang, Mei; Amanai, Manami; Wharton, Keith A.

Genetics ; 174(1): 331-48, 2006 Sep.

Artigo Inglês | MEDLINE | ID: mdl-16849595

16.

Elevated expression of Wnt antagonists is a common event in hepatoblastomas.

Koch, Arend; Waha, Andreas; Hartmann, Wolfgang; Hrychyk, Aksana; Schüller, Ulrich; Waha, Anke; Wharton, Keith A; Fuchs, Serge Y; von Schweinitz, Dietrich; Pietsch, Torsten.

Clin Cancer Res ; 11(12): 4295-304, 2005 Jun 15.

Artigo Inglês | MEDLINE | ID: mdl-15958610

17.

JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection.

Wharton, Keith A; Quigley, Catherine; Themeles, Marian; Dunstan, Robert W; Doyle, Kathryn; Cahir-McFarland, Ellen; Wei, Jing; Buko, Alex; Reid, Carl E; Sun, Chao; Carmillo, Paul; Sur, Gargi; Carulli, John P; Mansfield, Keith G; Westmoreland, Susan V; Staugaitis, Susan M; Fox, Robert J; Meier, Werner; Goelz, Susan E.

PLoS One ; 11(5): e0155897, 2016.

Artigo Inglês | MEDLINE | ID: mdl-27191595

18.

Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling.

Guo, Jianhui; Cagatay, Tolga; Zhou, Guangjin; Chan, Chih-Chiang; Blythe, Shelby; Suyama, Kaye; Zheng, Li; Pan, Kaifeng; Qian, Chiping; Hamelin, Richard; Thibodeau, Stephen N; Klein, Peter S; Wharton, Keith A; Liu, Wanguo.

PLoS One ; 4(11): e7982, 2009 Nov 24.

Artigo Inglês | MEDLINE | ID: mdl-19956716

19.

Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging.

DeCarolis, Nathan A; Wharton, Keith A; Eisch, Amelia J.

Bioessays ; 30(2): 102-6, 2008 Feb.

Artigo Inglês | MEDLINE | ID: mdl-18200563

20.

WNTers in La Jolla.

Sokol, Sergei Y; Wharton, Keith A.

Development ; 134(19): 3393-9, 2007 Oct.

Artigo Inglês | MEDLINE | ID: mdl-17827178

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