Detalhe da pesquisa
1.
AAV9 Gene Therapy Increases Lifespan and Treats Pathological and Behavioral Abnormalities in a Mouse Model of CLN8-Batten Disease.
Mol Ther
; 29(1): 162-175, 2021 01 06.
Artigo
Inglês
| MEDLINE | ID: mdl-33010819
2.
Gene Therapy Corrects Brain and Behavioral Pathologies in CLN6-Batten Disease.
Mol Ther
; 27(10): 1836-1847, 2019 10 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31331814
3.
Development of a tobacco 21 policy assessment tool and state-level analysis in the USA, 2015-2019.
Tob Control
; 29(5): 487-495, 2020 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31611425
4.
A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease.
Hum Mol Genet
; 24(22): 6473-84, 2015 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26374845
5.
Diet-induced obesity prolongs neuroinflammation and recruits CCR2(+) monocytes to the brain following herpes simplex virus (HSV)-1 latency in mice.
Brain Behav Immun
; 57: 68-78, 2016 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-27311830
6.
A novel porcine model of CLN3 Batten disease recapitulates clinical phenotypes.
Dis Model Mech
; 16(8)2023 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37305926
7.
Magnetic resonance brain volumetry biomarkers of CLN2 Batten disease identified with miniswine model.
Sci Rep
; 13(1): 5146, 2023 03 29.
Artigo
Inglês
| MEDLINE | ID: mdl-36991106
8.
Sortilin inhibition treats multiple neurodegenerative lysosomal storage disorders.
bioRxiv
; 2023 Sep 22.
Artigo
Inglês
| MEDLINE | ID: mdl-37790379
9.
Early postnatal administration of an AAV9 gene therapy is safe and efficacious in CLN3 disease.
Front Genet
; 14: 1118649, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37035740
10.
Sex-split analysis of pathology and motor-behavioral outcomes in a mouse model of CLN8-Batten disease reveals an increased disease burden and trajectory in female Cln8mnd mice.
Orphanet J Rare Dis
; 17(1): 411, 2022 11 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36369162
11.
A Novel Porcine Model of CLN2 Batten Disease that Recapitulates Patient Phenotypes.
Neurotherapeutics
; 19(6): 1905-1919, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36100791
12.
Tobacco 21 Policies in the U.S.: The Importance of Local Control With Federal Policy.
Am J Prev Med
; 60(5): 639-647, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33602533
13.
Intracranial delivery of AAV9 gene therapy partially prevents retinal degeneration and visual deficits in CLN6-Batten disease mice.
Mol Ther Methods Clin Dev
; 20: 497-507, 2021 Mar 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33665223
14.
Validating indicators of CNS disorders in a swine model of neurological disease.
PLoS One
; 15(2): e0228222, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32074109
15.
A multimodal approach to identify clinically relevant biomarkers to comprehensively monitor disease progression in a mouse model of pediatric neurodegenerative disease.
Prog Neurobiol
; 189: 101789, 2020 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32198061
16.
Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions.
Mol Neurobiol
; 56(10): 6736-6755, 2019 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-30915713
17.
Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease.
Neuronal Signal
; 3(2): NS20190001, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32269836
18.
Therapeutic landscape for Batten disease: current treatments and future prospects.
Nat Rev Neurol
; 15(3): 161-178, 2019 03.
Artigo
Inglês
| MEDLINE | ID: mdl-30783219
19.
Tracking sex-dependent differences in a mouse model of CLN6-Batten disease.
Orphanet J Rare Dis
; 14(1): 19, 2019 01 21.
Artigo
Inglês
| MEDLINE | ID: mdl-30665444
20.
Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1.
Pain
; 160(11): 2473-2486, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31246731