Detalhe da pesquisa
1.
The P300 acetyltransferase inhibitor C646 promotes membrane translocation of insulin receptor protein substrate and interaction with the insulin receptor.
J Biol Chem
; 298(3): 101621, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35074429
2.
Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.
J Biol Chem
; 296: 100646, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33839150
3.
From population to neuron: exploring common mediators for metabolic problems and mental illnesses.
Mol Psychiatry
; 26(8): 3931-3942, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33173197
4.
Irs2 deficiency alters hippocampus-associated behaviors during young adulthood.
Biochem Biophys Res Commun
; 559: 148-154, 2021 06 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33940386
5.
Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis.
Proc Natl Acad Sci U S A
; 115(16): 4228-4233, 2018 04 17.
Artigo
Inglês
| MEDLINE | ID: mdl-29610318
6.
Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1-mediated p53/KLF4 complex stabilization.
J Biol Chem
; 294(7): 2407-2421, 2019 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30578299
7.
Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma.
Proc Natl Acad Sci U S A
; 113(31): 8795-800, 2016 08 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27439864
8.
Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation.
J Biol Chem
; 292(5): 2009-2020, 2017 02 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28003360
9.
G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway.
J Biol Chem
; 291(53): 27160-27169, 2016 12 30.
Artigo
Inglês
| MEDLINE | ID: mdl-27856640
10.
Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.
J Biol Chem
; 291(16): 8602-17, 2016 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26846849
11.
IRS proteins and diabetic complications.
Diabetologia
; 59(11): 2280-2291, 2016 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27514532
12.
Longevity: Mapping the path to a longer life.
Nature
; 524(7564): 170-1, 2015 Aug 13.
Artigo
Inglês
| MEDLINE | ID: mdl-26268188
13.
Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.
J Biol Chem
; 289(18): 12467-84, 2014 May 02.
Artigo
Inglês
| MEDLINE | ID: mdl-24652289
14.
Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells.
J Biol Chem
; 288(33): 23807-13, 2013 Aug 16.
Artigo
Inglês
| MEDLINE | ID: mdl-23749991
15.
IRS1Ser³°7 phosphorylation does not mediate mTORC1-induced insulin resistance.
Biochem Biophys Res Commun
; 443(2): 689-93, 2014 Jan 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24333417
16.
Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K).
J Biol Chem
; 287(7): 4518-30, 2012 Feb 10.
Artigo
Inglês
| MEDLINE | ID: mdl-22158866
17.
IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation.
Cereb Cortex
; 22(8): 1717-27, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-21955917
18.
The role of hepatokines in NAFLD.
Cell Metab
; 35(2): 236-252, 2023 02 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36754018
19.
Hepatic follistatin increases basal metabolic rate and attenuates diet-induced obesity during hepatic insulin resistance.
Mol Metab
; 71: 101703, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36906067
20.
BRD7 improves glucose homeostasis independent of IRS proteins.
J Endocrinol
; 258(3)2023 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37578842