Pesquisa | Secretaria de Estado da Saúde

1.

Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.

Dalgaard, Kevin; Landgraf, Kathrin; Heyne, Steffen; Lempradl, Adelheid; Longinotto, John; Gossens, Klaus; Ruf, Marius; Orthofer, Michael; Strogantsev, Ruslan; Selvaraj, Madhan; Lu, Tess Tsai-Hsiu; Casas, Eduard; Teperino, Raffaele; Surani, M Azim; Zvetkova, Ilona; Rimmington, Debra; Tung, Y C Loraine; Lam, Brian; Larder, Rachel; Yeo, Giles S H; O'Rahilly, Stephen; Vavouri, Tanya; Whitelaw, Emma; Penninger, Josef M; Jenuwein, Thomas; Cheung, Ching-Lung; Ferguson-Smith, Anne C; Coll, Anthony P; Körner, Antje; Pospisilik, J Andrew.

Cell ; 164(3): 353-64, 2016 Jan 28.

Artigo Inglês | MEDLINE | ID: mdl-26824653

2.

Understanding transgenerational epigenetic inheritance via the gametes in mammals.

Daxinger, Lucia; Whitelaw, Emma.

Nat Rev Genet ; 13(3): 153-62, 2012 Jan 31.

Artigo Inglês | MEDLINE | ID: mdl-22290458

3.

Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome.

Isbel, Luke; Srivastava, Rahul; Oey, Harald; Spurling, Alex; Daxinger, Lucia; Puthalakath, Hamsa; Whitelaw, Emma.

PLoS Genet ; 11(12): e1005693, 2015 Dec.

Artigo Inglês | MEDLINE | ID: mdl-26624618

4.

Reintroducing domesticated wild mice to sociality induces adaptive transgenerational effects on MUP expression.

Nelson, Adam C; Cauceglia, Joseph W; Merkley, Seth D; Youngson, Neil A; Oler, Andrew J; Nelson, Randy J; Cairns, Bradley R; Whitelaw, Emma; Potts, Wayne K.

Proc Natl Acad Sci U S A ; 110(49): 19848-53, 2013 Dec 03.

Artigo Inglês | MEDLINE | ID: mdl-24248373

5.

The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers.

Harten, Sarah K; Oey, Harald; Bourke, Lauren M; Bharti, Vandhana; Isbel, Luke; Daxinger, Lucia; Faou, Pierre; Robertson, Neil; Matthews, Jacqueline M; Whitelaw, Emma.

BMC Biol ; 13: 21, 2015 Mar 26.

Artigo Inglês | MEDLINE | ID: mdl-25857663

6.

Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of α-globin transgene variegation.

Sorolla, Anabel; Tallack, Michael R; Oey, Harald; Harten, Sarah K; Daxinger, Lucia Clemens-; Magor, Graham W; Combes, Alex N; Ilsley, Melissa; Whitelaw, Emma; Perkins, Andrew C.

Genomics ; 105(2): 116-22, 2015 Feb.

Artigo Inglês | MEDLINE | ID: mdl-25451176

7.

Modifiers of epigenetic reprogramming show paternal effects in the mouse.

Chong, Suyinn; Vickaryous, Nicola; Ashe, Alyson; Zamudio, Natasha; Youngson, Neil; Hemley, Sarah; Stopka, Tomas; Skoultchi, Arthur; Matthews, Jacqui; Scott, Hamish S; de Kretser, David; O'Bryan, Moira; Blewitt, Marnie; Whitelaw, Emma.

Nat Genet ; 39(5): 614-22, 2007 May.

Artigo Inglês | MEDLINE | ID: mdl-17450140

8.

Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells.

Funnell, Alister P W; Vernimmen, Douglas; Lim, Wooi F; Mak, Ka Sin; Wienert, Beeke; Martyn, Gabriella E; Artuz, Crisbel M; Burdach, Jon; Quinlan, Kate G R; Higgs, Douglas R; Whitelaw, Emma; Pearson, Richard C M; Crossley, Merlin.

BMC Mol Biol ; 15: 8, 2014 May 16.

Artigo Inglês | MEDLINE | ID: mdl-24885809

9.

Non-telomeric epigenetic and genetic changes are associated with the inheritance of shorter telomeres in mice.

Roberts, Amity R; Huang, Edward; Jones, Lincoln; Daxinger, Lucia; Chong, Suyinn; Whitelaw, Emma.

Chromosoma ; 122(6): 541-54, 2013 Dec.

Artigo Inglês | MEDLINE | ID: mdl-23864360

10.

Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies.

Ashe, Alyson; Butterfield, Natalie C; Town, Liam; Courtney, Andrew D; Cooper, Ashley N; Ferguson, Charles; Barry, Rachael; Olsson, Fredrik; Liem, Karel F; Parton, Robert G; Wainwright, Brandon J; Anderson, Kathryn V; Whitelaw, Emma; Wicking, Carol.

Hum Mol Genet ; 21(8): 1808-23, 2012 Apr 15.

Artigo Inglês | MEDLINE | ID: mdl-22228095

11.

The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development.

Harten, Sarah K; Bruxner, Timothy J; Bharti, Vandhana; Blewitt, Marnie; Nguyen, Thi-My-Tam; Whitelaw, Emma; Epp, Trevor.

Mamm Genome ; 25(7-8): 293-303, 2014 Aug.

Artigo Inglês | MEDLINE | ID: mdl-24781204

12.

Endogenous retroviruses in mammals: an emerging picture of how ERVs modify expression of adjacent genes.

Isbel, Luke; Whitelaw, Emma.

Bioessays ; 34(9): 734-8, 2012 Sep.

Artigo Inglês | MEDLINE | ID: mdl-22736292

13.

Transgenerational epigenetic inheritance: more questions than answers.

Daxinger, Lucia; Whitelaw, Emma.

Genome Res ; 20(12): 1623-8, 2010 Dec.

Artigo Inglês | MEDLINE | ID: mdl-21041414

14.

No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations.

Youngson, Neil A; Epp, Trevor; Roberts, Amity R; Daxinger, Lucia; Ashe, Alyson; Huang, Edward; Lester, Krystal L; Harten, Sarah K; Kay, Graham F; Cox, Timothy; Matthews, Jacqueline M; Chong, Suyinn; Whitelaw, Emma.

Mamm Genome ; 24(5-6): 206-17, 2013 Jun.

Artigo Inglês | MEDLINE | ID: mdl-23636699

15.

ENU mutagenesis identifies the first mouse mutants reproducing human ß-thalassemia at the genomic level.

Brown, Fiona C; Scott, Nicholas; Rank, Gerhard; Collinge, Janelle E; Vadolas, Jim; Vickaryous, Nicola; Whitelaw, Nadia; Whitelaw, Emma; Kile, Benjamin T; Jane, Stephen M; Curtis, David J.

Blood Cells Mol Dis ; 50(2): 86-92, 2013 Feb.

Artigo Inglês | MEDLINE | ID: mdl-23040355

16.

Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model.

Kaminen-Ahola, Nina; Ahola, Arttu; Maga, Murat; Mallitt, Kylie-Ann; Fahey, Paul; Cox, Timothy C; Whitelaw, Emma; Chong, Suyinn.

PLoS Genet ; 6(1): e1000811, 2010 Jan 15.

Artigo Inglês | MEDLINE | ID: mdl-20084100

17.

Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo.

Roberts, Amity R; Blewitt, Marnie E; Youngson, Neil A; Whitelaw, Emma; Chong, Suyinn.

Chromosoma ; 120(4): 377-85, 2011 Aug.

Artigo Inglês | MEDLINE | ID: mdl-21553025

18.

Transgenerational epigenetic inheritance in health and disease.

Whitelaw, Nadia C; Whitelaw, Emma.

Curr Opin Genet Dev ; 18(3): 273-9, 2008 Jun.

Artigo Inglês | MEDLINE | ID: mdl-18662779

19.

The characterisation of piRNA-related 19mers in the mouse.

Oey, Harald M; Youngson, Neil A; Whitelaw, Emma.

BMC Genomics ; 12: 315, 2011 Jun 15.

Artigo Inglês | MEDLINE | ID: mdl-21672259

20.

Unravelling the X in sex.

Whitelaw, Emma.

Dev Cell ; 11(6): 759-62, 2006 Dec.

Artigo Inglês | MEDLINE | ID: mdl-17180766

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