Detalhe da pesquisa
1.
MEnTaT: A machine-learning approach for the identification of mutations to increase protein stability.
Proc Natl Acad Sci U S A
; 120(49): e2309884120, 2023 Dec 05.
Artigo
Inglês
| MEDLINE | ID: mdl-38039271
2.
A conserved core region of the scaffold NEMO is essential for signal-induced conformational change and liquid-liquid phase separation.
J Biol Chem
; 299(12): 105396, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37890781
3.
The anti-Müllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor.
J Biol Chem
; 298(1): 101429, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34801555
4.
High Accuracy Prediction of PROTAC Complex Structures.
J Am Chem Soc
; 145(13): 7123-7135, 2023 04 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36961978
5.
Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.
J Am Chem Soc
; 143(10): 3779-3793, 2021 03 17.
Artigo
Inglês
| MEDLINE | ID: mdl-33683866
6.
Exploring the structural origins of cryptic sites on proteins.
Proc Natl Acad Sci U S A
; 115(15): E3416-E3425, 2018 04 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29581267
7.
Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2).
Biochemistry
; 59(4): 563-581, 2020 02 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31851823
8.
Benchmark Sets for Binding Hot Spot Identification in Fragment-Based Ligand Discovery.
J Chem Inf Model
; 60(12): 6612-6623, 2020 12 28.
Artigo
Inglês
| MEDLINE | ID: mdl-33291870
9.
A Central Region of NF-κB Essential Modulator Is Required for IKKß-Induced Conformational Change and for Signal Propagation.
Biochemistry
; 58(26): 2906-2920, 2019 07 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31145594
10.
Ligand deconstruction: Why some fragment binding positions are conserved and others are not.
Proc Natl Acad Sci U S A
; 112(20): E2585-94, 2015 May 19.
Artigo
Inglês
| MEDLINE | ID: mdl-25918377
11.
Progress towards the broad use of non-peptide synthetic macrocycles in drug discovery.
Org Biomol Chem
; 15(37): 7729-7735, 2017 Sep 26.
Artigo
Inglês
| MEDLINE | ID: mdl-28876025
12.
Quantitative analysis of receptor tyrosine kinase-effector coupling at functionally relevant stimulus levels.
J Biol Chem
; 290(16): 10018-36, 2015 Apr 17.
Artigo
Inglês
| MEDLINE | ID: mdl-25635057
13.
How proteins bind macrocycles.
Nat Chem Biol
; 10(9): 723-31, 2014 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-25038790
14.
Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines.
Molecules
; 20(5): 7474-94, 2015 Apr 23.
Artigo
Inglês
| MEDLINE | ID: mdl-25915462
15.
Understanding cytokine and growth factor receptor activation mechanisms.
Crit Rev Biochem Mol Biol
; 47(6): 502-30, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-23046381
16.
Disulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO).
Biochemistry
; 53(50): 7929-44, 2014 Dec 23.
Artigo
Inglês
| MEDLINE | ID: mdl-25400026
17.
Structural conservation of druggable hot spots in protein-protein interfaces.
Proc Natl Acad Sci U S A
; 108(33): 13528-33, 2011 Aug 16.
Artigo
Inglês
| MEDLINE | ID: mdl-21808046
18.
Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-ß with high affinity.
Biochemistry
; 52(51): 9141-54, 2013 Dec 23.
Artigo
Inglês
| MEDLINE | ID: mdl-24266532
19.
Comprehensive experimental and computational analysis of binding energy hot spots at the NF-κB essential modulator/IKKß protein-protein interface.
J Am Chem Soc
; 135(16): 6242-56, 2013 Apr 24.
Artigo
Inglês
| MEDLINE | ID: mdl-23506214
20.
Determining the affinity and stoichiometry of interactions between unmodified proteins in solution using Biacore.
Anal Biochem
; 440(1): 96-107, 2013 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23711722