Pesquisa | Secretaria de Estado da Saúde

1.

The long-term genetic stability and individual specificity of the human gut microbiome.

Chen, Lianmin; Wang, Daoming; Garmaeva, Sanzhima; Kurilshikov, Alexander; Vich Vila, Arnau; Gacesa, Ranko; Sinha, Trishla; Segal, Eran; Weersma, Rinse K; Wijmenga, Cisca; Zhernakova, Alexandra; Fu, Jingyuan.

Cell ; 184(9): 2302-2315.e12, 2021 04 29.

Artigo Inglês | MEDLINE | ID: mdl-33838112

2.

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.

Mayassi, Toufic; Ladell, Kristin; Gudjonson, Herman; McLaren, James E; Shaw, Dustin G; Tran, Mai T; Rokicka, Jagoda J; Lawrence, Ian; Grenier, Jean-Christophe; van Unen, Vincent; Ciszewski, Cezary; Dimaano, Matthew; Sayegh, Hoda E; Kumar, Vinod; Wijmenga, Cisca; Green, Peter H R; Gokhale, Ranjana; Jericho, Hilary; Semrad, Carol E; Guandalini, Stefano; Dinner, Aaron R; Kupfer, Sonia S; Reid, Hugh H; Barreiro, Luis B; Rossjohn, Jamie; Price, David A; Jabri, Bana.

Cell ; 176(5): 967-981.e19, 2019 02 21.

Artigo Inglês | MEDLINE | ID: mdl-30739797

3.

Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model.

Wray, Naomi R; Wijmenga, Cisca; Sullivan, Patrick F; Yang, Jian; Visscher, Peter M.

Cell ; 173(7): 1573-1580, 2018 06 14.

Artigo Inglês | MEDLINE | ID: mdl-29906445

4.

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire.

Andreu-Sánchez, Sergio; Bourgonje, Arno R; Vogl, Thomas; Kurilshikov, Alexander; Leviatan, Sigal; Ruiz-Moreno, Angel J; Hu, Shixian; Sinha, Trishla; Vich Vila, Arnau; Klompus, Shelley; Kalka, Iris N; de Leeuw, Karina; Arends, Suzanne; Jonkers, Iris; Withoff, Sebo; Brouwer, Elisabeth; Weinberger, Adina; Wijmenga, Cisca; Segal, Eran; Weersma, Rinse K; Fu, Jingyuan; Zhernakova, Alexandra.

Immunity ; 56(6): 1376-1392.e8, 2023 06 13.

Artigo Inglês | MEDLINE | ID: mdl-37164013

5.

Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures.

Bourgonje, Arno R; Andreu-Sánchez, Sergio; Vogl, Thomas; Hu, Shixian; Vich Vila, Arnau; Gacesa, Ranko; Leviatan, Sigal; Kurilshikov, Alexander; Klompus, Shelley; Kalka, Iris N; van Dullemen, Hendrik M; Weinberger, Adina; Visschedijk, Marijn C; Festen, Eleonora A M; Faber, Klaas Nico; Wijmenga, Cisca; Dijkstra, Gerard; Segal, Eran; Fu, Jingyuan; Zhernakova, Alexandra; Weersma, Rinse K.

Immunity ; 56(6): 1393-1409.e6, 2023 06 13.

Artigo Inglês | MEDLINE | ID: mdl-37164015

6.

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.

Schirmer, Melanie; Smeekens, Sanne P; Vlamakis, Hera; Jaeger, Martin; Oosting, Marije; Franzosa, Eric A; Ter Horst, Rob; Jansen, Trees; Jacobs, Liesbeth; Bonder, Marc Jan; Kurilshikov, Alexander; Fu, Jingyuan; Joosten, Leo A B; Zhernakova, Alexandra; Huttenhower, Curtis; Wijmenga, Cisca; Netea, Mihai G; Xavier, Ramnik J.

Cell ; 167(4): 1125-1136.e8, 2016 11 03.

Artigo Inglês | MEDLINE | ID: mdl-27814509

7.

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

Li, Yang; Oosting, Marije; Smeekens, Sanne P; Jaeger, Martin; Aguirre-Gamboa, Raul; Le, Kieu T T; Deelen, Patrick; Ricaño-Ponce, Isis; Schoffelen, Teske; Jansen, Anne F M; Swertz, Morris A; Withoff, Sebo; van de Vosse, Esther; van Deuren, Marcel; van de Veerdonk, Frank; Zhernakova, Alexandra; van der Meer, Jos W M; Xavier, Ramnik J; Franke, Lude; Joosten, Leo A B; Wijmenga, Cisca; Kumar, Vinod; Netea, Mihai G.

Cell ; 167(4): 1099-1110.e14, 2016 11 03.

Artigo Inglês | MEDLINE | ID: mdl-27814507

8.

Host and Environmental Factors Influencing Individual Human Cytokine Responses.

Ter Horst, Rob; Jaeger, Martin; Smeekens, Sanne P; Oosting, Marije; Swertz, Morris A; Li, Yang; Kumar, Vinod; Diavatopoulos, Dimitri A; Jansen, Anne F M; Lemmers, Heidi; Toenhake-Dijkstra, Helga; van Herwaarden, Antonius E; Janssen, Matthijs; van der Molen, Renate G; Joosten, Irma; Sweep, Fred C G J; Smit, Johannes W; Netea-Maier, Romana T; Koenders, Mieke M J F; Xavier, Ramnik J; van der Meer, Jos W M; Dinarello, Charles A; Pavelka, Norman; Wijmenga, Cisca; Notebaart, Richard A; Joosten, Leo A B; Netea, Mihai G.

Cell ; 167(4): 1111-1124.e13, 2016 11 03.

Artigo Inglês | MEDLINE | ID: mdl-27814508

9.

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses.

Bakker, Olivier B; Aguirre-Gamboa, Raul; Sanna, Serena; Oosting, Marije; Smeekens, Sanne P; Jaeger, Martin; Zorro, Maria; Võsa, Urmo; Withoff, Sebo; Netea-Maier, Romana T; Koenen, Hans J P M; Joosten, Irma; Xavier, Ramnik J; Franke, Lude; Joosten, Leo A B; Kumar, Vinod; Wijmenga, Cisca; Netea, Mihai G; Li, Yang.

Nat Immunol ; 19(7): 776-786, 2018 07.

Artigo Inglês | MEDLINE | ID: mdl-29784908

10.

Host genetic regulation of human gut microbial structural variation.

Zhernakova, Daria V; Wang, Daoming; Liu, Lei; Andreu-Sánchez, Sergio; Zhang, Yue; Ruiz-Moreno, Angel J; Peng, Haoran; Plomp, Niels; Del Castillo-Izquierdo, Ángela; Gacesa, Ranko; Lopera-Maya, Esteban A; Temba, Godfrey S; Kullaya, Vesla I; van Leeuwen, Sander S; Xavier, Ramnik J; de Mast, Quirijn; Joosten, Leo A B; Riksen, Niels P; Rutten, Joost H W; Netea, Mihai G; Sanna, Serena; Wijmenga, Cisca; Weersma, Rinse K; Zhernakova, Alexandra; Harmsen, Hermie J M; Fu, Jingyuan.

Nature ; 625(7996): 813-821, 2024 Jan.

Artigo Inglês | MEDLINE | ID: mdl-38172637

11.

iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies.

Palasantzas, Victoria E J M; Tamargo-Rubio, Isabel; Le, Kieu; Slager, Jelle; Wijmenga, Cisca; Jonkers, Iris H; Kumar, Vinod; Fu, Jingyuan; Withoff, Sebo.

Trends Genet ; 39(4): 268-284, 2023 04.

Artigo Inglês | MEDLINE | ID: mdl-36746737

12.

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.

Schirmer, Melanie; Smeekens, Sanne P; Vlamakis, Hera; Jaeger, Martin; Oosting, Marije; Franzosa, Eric A; Horst, Rob Ter; Jansen, Trees; Jacobs, Liesbeth; Bonder, Marc Jan; Kurilshikov, Alexander; Fu, Jingyuan; Joosten, Leo A B; Zhernakova, Alexandra; Huttenhower, Curtis; Wijmenga, Cisca; Netea, Mihai G; Xavier, Ramnik J.

Cell ; 167(7): 1897, 2016 12 15.

Artigo Inglês | MEDLINE | ID: mdl-27984736

13.

Structural variation in the gut microbiome associates with host health.

Zeevi, David; Korem, Tal; Godneva, Anastasia; Bar, Noam; Kurilshikov, Alexander; Lotan-Pompan, Maya; Weinberger, Adina; Fu, Jingyuan; Wijmenga, Cisca; Zhernakova, Alexandra; Segal, Eran.

Nature ; 568(7750): 43-48, 2019 04.

Artigo Inglês | MEDLINE | ID: mdl-30918406

14.

Genetic variation in Toll-like receptors and disease susceptibility.

Netea, Mihai G; Wijmenga, Cisca; O'Neill, Luke A J.

Nat Immunol ; 13(6): 535-42, 2012 May 18.

Artigo Inglês | MEDLINE | ID: mdl-22610250

15.

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.

Cao, Zhifang; Conway, Kara L; Heath, Robert J; Rush, Jason S; Leshchiner, Elizaveta S; Ramirez-Ortiz, Zaida G; Nedelsky, Natalia B; Huang, Hailiang; Ng, Aylwin; Gardet, Agnès; Cheng, Shih-Chin; Shamji, Alykhan F; Rioux, John D; Wijmenga, Cisca; Netea, Mihai G; Means, Terry K; Daly, Mark J; Xavier, Ramnik J.

Immunity ; 43(4): 715-26, 2015 Oct 20.

Artigo Inglês | MEDLINE | ID: mdl-26488816

16.

Environment dominates over host genetics in shaping human gut microbiota.

Rothschild, Daphna; Weissbrod, Omer; Barkan, Elad; Kurilshikov, Alexander; Korem, Tal; Zeevi, David; Costea, Paul I; Godneva, Anastasia; Kalka, Iris N; Bar, Noam; Shilo, Smadar; Lador, Dar; Vila, Arnau Vich; Zmora, Niv; Pevsner-Fischer, Meirav; Israeli, David; Kosower, Noa; Malka, Gal; Wolf, Bat Chen; Avnit-Sagi, Tali; Lotan-Pompan, Maya; Weinberger, Adina; Halpern, Zamir; Carmi, Shai; Fu, Jingyuan; Wijmenga, Cisca; Zhernakova, Alexandra; Elinav, Eran; Segal, Eran.

Nature ; 555(7695): 210-215, 2018 03 08.

Artigo Inglês | MEDLINE | ID: mdl-29489753

17.

An integrative genomics approach identifies KDM4 as a modulator of trained immunity.

Moorlag, Simone J C F M; Matzaraki, Vasiliki; van Puffelen, Jelmer H; van der Heijden, Charlotte; Keating, Sam; Groh, Laszlo; Röring, Rutger Jan; Bakker, Olivier B; Mourits, Vera P; Koeken, Valerie A C M; de Bree, L Charlotte J; Smeekens, Sanne P; Oosting, Marije; Gamboa, Raúl Aguirre; Riksen, Niels P; Xavier, Ramnik J; Wijmenga, Cisca; Kumar, Vinod; van Crevel, Reinout; Novakovic, Boris; Joosten, Leo A B; Li, Yang; Netea, Mihai G.

Eur J Immunol ; 52(3): 431-446, 2022 03.

Artigo Inglês | MEDLINE | ID: mdl-34821391

18.

Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients.

Brand, Eelco C; Klaassen, Marjolein A Y; Gacesa, Ranko; Vich Vila, Arnau; Ghosh, Hiren; de Zoete, Marcel R; Boomsma, Dorret I; Hoentjen, Frank; Horjus Talabur Horje, Carmen S; van de Meeberg, Paul C; Willemsen, Gonneke; Fu, Jingyuan; Wijmenga, Cisca; van Wijk, Femke; Zhernakova, Alexandra; Oldenburg, Bas; Weersma, Rinse K.

Gastroenterology ; 160(6): 1970-1985, 2021 05.

Artigo Inglês | MEDLINE | ID: mdl-33476671

19.

Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study.

Doestzada, Marwah; Zhernakova, Daria V; C L van den Munckhof, Inge; Wang, Daoming; Kurilshikov, Alexander; Chen, Lianmin; Bloks, Vincent W; van Faassen, Martijn; Rutten, Joost H W; Joosten, Leo A B; Netea, Mihai G; Wijmenga, Cisca; Riksen, Niels P; Zhernakova, Alexandra; Kuipers, Folkert; Fu, Jingyuan.

BMC Med ; 20(1): 485, 2022 12 15.

Artigo Inglês | MEDLINE | ID: mdl-36522747

20.

From LD-based mapping to GWAS.

Wijmenga, Cisca.

Nat Rev Genet ; 22(8): 480-481, 2021 08.

Artigo Inglês | MEDLINE | ID: mdl-33893454

Secretaria de Estado da Saúde - BVS

Rede de Informação e Conhecimento

Sua seleção (0)

Formato de exportação:

Exportar:

The long-term genetic stability and individual specificity of the human gut microbiome.

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.

Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model.

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire.

Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures.

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

Host and Environmental Factors Influencing Individual Human Cytokine Responses.

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses.

Host genetic regulation of human gut microbial structural variation.

iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies.

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.

Structural variation in the gut microbiome associates with host health.

Genetic variation in Toll-like receptors and disease susceptibility.

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.

Environment dominates over host genetics in shaping human gut microbiota.

An integrative genomics approach identifies KDM4 as a modulator of trained immunity.

Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients.

Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study.

From LD-based mapping to GWAS.