RESUMO
Spiral fMRI has been put forward as a viable alternative to rectilinear echo-planar imaging, in particular due to its enhanced average k-space speed and thus high acquisition efficiency. This renders spirals attractive for contemporary fMRI applications that require high spatiotemporal resolution, such as laminar or columnar fMRI. However, in practice, spiral fMRI is typically hampered by its reduced robustness and ensuing blurring artifacts, which arise from imperfections in both static and dynamic magnetic fields. Recently, these limitations have been overcome by the concerted application of an expanded signal model that accounts for such field imperfections, and its inversion by iterative image reconstruction. In the challenging ultra-high field environment of 7 Tesla, where field inhomogeneity effects are aggravated, both multi-shot and single-shot 2D spiral imaging at sub-millimeter resolution was demonstrated with high depiction quality and anatomical congruency. In this work, we further these advances towards a time series application of spiral readouts, namely, single-shot spiral BOLD fMRI at 0.8 mm in-plane resolution. We demonstrate that high-resolution spiral fMRI at 7 T is not only feasible, but delivers both excellent image quality, BOLD sensitivity, and spatial specificity of the activation maps, with little artifactual blurring. Furthermore, we show the versatility of the approach with a combined in/out spiral readout at a more typical resolution (1.5 mm), where the high acquisition efficiency allows to acquire two images per shot for improved sensitivity by echo combination.
Assuntos
Encéfalo/diagnóstico por imagem , Encéfalo/fisiologia , Neuroimagem Funcional/métodos , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Adulto , Estudos de Viabilidade , Feminino , Humanos , Masculino , Adulto JovemRESUMO
PURPOSE: Many aspects and imperfections of gradient dynamics in MRI have been successfully captured by linear time-invariant (LTI) models. Changes in gradient behavior due to heating, however, violate time invariance. The goal of this work is to study such changes at the level of transfer functions and model them by thermal extension of the LTI framework. METHODS: To study the impact of gradient heating on transfer functions, a clinical MR system was heated using a range of high-amplitude DC and AC waveforms, each followed by measuring transfer functions in rapid succession while the system cooled down. Simultaneously, gradient temperature was monitored with an array of temperature sensors positioned according to initial infrared recordings of the gradient tube. The relation between temperatures and transfer functions is cast into local and global linear models. The models are analysed in terms of self-consistency, conditioning, and prediction performance. RESULTS: Pronounced thermal effects are observed in the time resolved transfer functions, largely attributable to in-coil eddy currents and mechanical resonances. Thermal modeling is found to capture these effects well. The keys to good model performance are well-placed temperature sensors and suitable training data. CONCLUSION: Heating changes gradient response, violating time invariance. The utility of LTI modeling can nevertheless be recovered by a linear thermal extension, relying on temperature sensing and adequate one-time training.
Assuntos
Imageamento por Ressonância Magnética , Modelos Lineares , Imagens de FantasmasRESUMO
Spiral imaging is very well suited for functional MRI, however its use has been limited by the fact that artifacts caused by gradient imperfections and B0 inhomogeneity are more difficult to correct compared to EPI. Effective correction requires accurate knowledge of the traversed k-space trajectory. With the goal of making spiral fMRI more accessible, we have evaluated image reconstruction using trajectories predicted by the gradient impulse response function (GIRF), which can be determined in a one-time calibration step. GIRF-predicted reconstruction was tested for high-resolution (0.8 mm) fMRI at 7T. Image quality and functional results of the reconstructions using GIRF-prediction were compared to reconstructions using the nominal trajectory and concurrent field monitoring. The reconstructions using nominal spiral trajectories contain substantial artifacts and the activation maps contain misplaced activation. Image artifacts are substantially reduced when using the GIRF-predicted reconstruction, and the activation maps for the GIRF-predicted and monitored reconstructions largely overlap. The GIRF reconstruction provides a large increase in the spatial specificity of the activation compared to the nominal reconstruction. The GIRF-reconstruction generates image quality and fMRI results similar to using a concurrently monitored trajectory. The presented approach does not prolong or complicate the fMRI acquisition. Using GIRF-predicted trajectories has the potential to enable high-quality spiral fMRI in situations where concurrent trajectory monitoring is not available.
Assuntos
Imageamento por Ressonância Magnética/métodos , Algoritmos , Artefatos , Mapeamento Encefálico , Calibragem , Estudos de Viabilidade , Humanos , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/métodos , Processamento de Imagem Assistida por Computador/métodos , Imagens de FantasmasRESUMO
PURPOSE: Spiral readouts combine several favorable properties that promise superior net sensitivity for diffusion imaging. The purpose of this study is to verify the signal-to-noise ratio (SNR) benefit of spiral acquisition in comparison with current echo-planar imaging (EPI) schemes. METHODS: Diffusion-weighted in vivo brain data from three subjects were acquired with a single-shot spiral sequence and several variants of single-shot EPI, including full-Fourier and partial-Fourier readouts as well as different diffusion-encoding schemes. Image reconstruction was based on an expanded signal model including field dynamics obtained by concurrent field monitoring. The effective resolution of each sequence was matched to that of full-Fourier EPI with 1 mm nominal resolution. SNR maps were generated by determining the noise statistics of the raw data and analyzing the propagation of equivalent synthetic noise through image reconstruction. Using the same approach, maps of noise amplification due to parallel imaging (g-factor) were calculated for different acceleration factors. RESULTS: Relative to full-Fourier EPI at b = 0 s/mm2 , spiral acquisition yielded SNR gains of 42-88% and 40-89% in white and gray matter, respectively, depending on the diffusion-encoding scheme. Relative to partial-Fourier EPI, the gains were 36-44% and 34-42%. Spiral g-factor maps exhibited less spatial variation and lower maxima than their EPI counterparts. CONCLUSION: Spiral readouts achieve significant SNR gains in the order of 40-80% over EPI in diffusion imaging at 3T. Combining systematic effects of shorter echo time, readout efficiency, and favorable g-factor behavior, similar benefits are expected across clinical and neurosciences uses of diffusion imaging.
Assuntos
Imagem de Difusão por Ressonância Magnética , Imagem Ecoplanar , Encéfalo/diagnóstico por imagem , Humanos , Processamento de Imagem Assistida por Computador , Razão Sinal-RuídoRESUMO
We report the deployment of spiral acquisition for high-resolution structural imaging at 7T. Long spiral readouts are rendered manageable by an expanded signal model including static off-resonance and B0 dynamics along with k-space trajectories and coil sensitivity maps. Image reconstruction is accomplished by inversion of the signal model using an extension of the iterative non-Cartesian SENSE algorithm. Spiral readouts up to 25 ms are shown to permit whole-brain 2D imaging at 0.5 mm in-plane resolution in less than a minute. A range of options is explored, including proton-density and T2* contrast, acceleration by parallel imaging, different readout orientations, and the extraction of phase images. Results are shown to exhibit competitive image quality along with high geometric consistency.
Assuntos
Encéfalo/diagnóstico por imagem , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Adulto , Encéfalo/anatomia & histologia , Feminino , Humanos , Masculino , Adulto JovemRESUMO
PURPOSE: MRI of tissues with short coherence lifetimes T2 or T2* can be performed efficiently using zero echo time (ZTE) techniques such as algebraic ZTE, pointwise encoding time reduction with radial acquisition (PETRA), and water- and fat-suppressed proton projection MRI (WASPI). They share the principal challenge of recovering data in central k-space missed due to an initial radiofrequency dead time. The purpose of this study was to compare the three techniques directly, with a particular focus on their behavior in the presence of ultra-short-lived spins. METHODS: The most direct comparison was enabled by aligning acquisition and reconstruction strategies of the three techniques. Image quality and short- T2* performance were investigated using point spread functions, 3D simulations, and imaging of phantom and bone samples with short (<1 ms) and ultra-short (<100 µs) T2*. RESULTS: Algebraic ZTE offers favorable properties but is limited to k-space gaps up to approximately three Nyquist dwells. At larger gaps, PETRA enables robust imaging with little compromise in image quality, whereas WASPI may be prone to artifacts from ultra-short T2* species. CONCLUSION: For small k-space gaps (<4 dwells) and T2* much larger than the dead time, all techniques enable artifact-free short- T2* MRI. However, if these requirements are not fulfilled careful consideration is needed and PETRA will generally achieve better image quality. Magn Reson Med 79:2036-2045, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Assuntos
Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética , Algoritmos , Animais , Artefatos , Osso e Ossos/diagnóstico por imagem , Bovinos , Simulação por Computador , Humanos , Interpretação de Imagem Assistida por Computador , Imageamento Tridimensional , Modelos Teóricos , Imagens de Fantasmas , Polimetil Metacrilato/química , Prótons , Ondas de Rádio , Tíbia/diagnóstico por imagemRESUMO
PURPOSE: To develop a method of tracking active NMR markers that requires no alterations of common imaging sequences and can be used for prospective motion correction (PMC) in brain MRI. METHODS: Localization of NMR markers is achieved by acquiring short signal snippets in rapid succession and evaluating them jointly. To spatially encode the markers, snippets are timed such that signal phase is accrued during sequence intervals with suitably diverse gradient actuation. For motion tracking and PMC in brain imaging, the markers are mounted on a lightweight headset. PMC is then demonstrated with high-resolution T2 *- and T1 -weighted imaging sequences in the presence of instructed as well as residual unintentional head motion. RESULTS: With both unaltered sequences, motion tracking was achieved with precisions on the order of 10 µm and 0.01° and temporal resolution of 48 and 39 ms, respectively. On this basis, PMC improved image quality significantly throughout. CONCLUSION: The proposed approach permits high-precision motion tracking and PMC with standard imaging sequences. It does so without altering sequence design and thus overcomes a key hindrance to routine motion tracking with NMR markers. Magn Reson Med 79:2046-2057, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Assuntos
Encéfalo/diagnóstico por imagem , Cabeça/diagnóstico por imagem , Imageamento por Ressonância Magnética , Espectroscopia de Ressonância Magnética , Calibragem , Desenho de Equipamento , Voluntários Saudáveis , Humanos , Processamento de Imagem Assistida por Computador , Movimento (Física) , Imagens de Fantasmas , Processamento de Sinais Assistido por Computador , Razão Sinal-RuídoRESUMO
PURPOSE: The purpose of this work was to improve the quality of single-shot spiral MRI and demonstrate its application for diffusion-weighted imaging. METHODS: Image formation is based on an expanded encoding model that accounts for dynamic magnetic fields up to third order in space, nonuniform static B0 , and coil sensitivity encoding. The encoding model is determined by B0 mapping, sensitivity mapping, and concurrent field monitoring. Reconstruction is performed by iterative inversion of the expanded signal equations. Diffusion-tensor imaging with single-shot spiral readouts is performed in a phantom and in vivo, using a clinical 3T instrument. Image quality is assessed in terms of artefact levels, image congruence, and the influence of the different encoding factors. RESULTS: Using the full encoding model, diffusion-weighted single-shot spiral imaging of high quality is accomplished both in vitro and in vivo. Accounting for actual field dynamics, including higher orders, is found to be critical to suppress blurring, aliasing, and distortion. Enhanced image congruence permitted data fusion and diffusion tensor analysis without coregistration. CONCLUSION: Use of an expanded signal model largely overcomes the traditional vulnerability of spiral imaging with long readouts. It renders single-shot spirals competitive with echo-planar readouts and thus deploys shorter echo times and superior readout efficiency for diffusion imaging and further prospective applications. Magn Reson Med 77:83-91, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Assuntos
Imagem de Difusão por Ressonância Magnética/métodos , Processamento de Imagem Assistida por Computador/métodos , Algoritmos , Encéfalo/diagnóstico por imagem , Humanos , Masculino , Imagens de FantasmasRESUMO
PURPOSE: MR image formation and interpretation relies on highly accurate dynamic magnetic fields of high fidelity. A range of mechanisms still limit magnetic field fidelity, including magnet drifts, eddy currents, and finite linearity and stability of power amplifiers used to drive gradient and shim coils. Addressing remaining errors by means of hardware, sequence, or signal processing optimizations, calls for immediate observation by magnetic field monitoring. The present work presents a stand-alone monitoring system delivering insight into such field imperfections for MR sequence and system analysis. METHODS: A flexible NMR field probe-based stand-alone monitoring system, built on a software-defined-radio approach, is introduced and used to sense field dynamics up to third-order in space in a selection of situations with different time scales. RESULTS: Highly sensitive trajectories are measured and successfully used for image reconstruction. Further field perturbations due to mechanical oscillations and thermal field drifts following demanding gradient use and external interferences are studied. CONCLUSION: A flexible and versatile monitoring system is presented, delivering camera-like access to otherwise hardly accessible field dynamics with nanotesla resolution. Its stand-alone nature enables field analysis even during unknown MR system states.
Assuntos
Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/instrumentação , Processamento de Sinais Assistido por Computador , Encéfalo/diagnóstico por imagem , Desenho de Equipamento , Humanos , Imageamento por Ressonância Magnética/métodos , Imagens de FantasmasRESUMO
PURPOSE: Real-time field control can serve to reduce respiratory field perturbations during T2 * imaging at high fields. This work investigates the effectiveness of this approach in relation to key variables such as patient physique, breathing patterns, slice location, and the choice of sequence. METHODS: To cover variation in physical constitution and breathing behavior, volunteers with a wide range of body-mass-indices were asked to breathe either normally or deeply during T2 *-weighted image acquisition at 7T. Ensuing field fluctuation was countered by real-time field control or merely recorded in reference experiments. The impact of the control system on image quality was assessed by classifying and grading artifacts related to field fluctuation. RESULTS: The amplitude of respiratory field changes and related artifacts were generally stronger for subjects with higher body-mass-index and for lower slices. Field control was found effective at mitigating all five types of artifacts that were studied. Overall image quality was systematically improved. Residual artifacts in low slices are attributed to insufficient spatial order of the control system. CONCLUSION: Real-time field control was found to be a robust means of countering respiratory field perturbations in variable conditions encountered in high-field brain imaging. Reducing net fluctuation, it generally expands the feasibility of high-field T2 * imaging toward challenging patients and brain regions. Magn Reson Med 76:430-439, 2016. © 2015 Wiley Periodicals, Inc.
Assuntos
Artefatos , Encéfalo/anatomia & histologia , Imagem de Difusão por Ressonância Magnética/métodos , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/métodos , Técnicas de Imagem de Sincronização Respiratória/métodos , Algoritmos , Sistemas Computacionais , Campos Eletromagnéticos , Feminino , Humanos , Masculino , Radiometria/métodos , Reprodutibilidade dos Testes , Mecânica Respiratória , Sensibilidade e EspecificidadeRESUMO
Reconstruction of MRI data is based on exact knowledge of all magnetic field dynamics, since the interplay of RF and gradient pulses generates the signal, defines the contrast and forms the basis of resolution in spatial and spectral dimensions. Deviations caused by various sources, such as system imperfections, delays, eddy currents, drifts or externally induced fields, can therefore critically limit the accuracy of MRI examinations. This is true especially at ultra-high fields, because many error terms scale with the main field strength, and higher available SNR renders even smaller errors relevant. Higher baseline field also often requires higher acquisition bandwidths and faster signal encoding, increasing hardware demands and the severity of many types of hardware imperfection. To address field imperfections comprehensively, in this work we propose to expand the concept of magnetic field monitoring to also encompass the recording of RF fields. In this way, all dynamic magnetic fields relevant for spin evolution are covered, including low- to audio-frequency magnetic fields as produced by main magnets, gradients and shim systems, as well as RF pulses generated with single- and multiple-channel transmission systems. The proposed approach permits field measurements concurrently with actual MRI procedures on a strict common time base. The combined measurement is achieved with an array of miniaturized field probes that measure low- to audio-frequency fields via (19) F NMR and simultaneously pick up RF pulses in the MRI system's (1) H transmit band. Field recordings can form the basis of system calibration, retrospective correction of imaging data or closed-loop feedback correction, all of which hold potential to render MRI more robust and relax hardware requirements. The proposed approach is demonstrated for a range of imaging methods performed on a 7 T human MRI system, including accelerated multiple-channel RF pulses. Copyright © 2015 John Wiley & Sons, Ltd.
Assuntos
Imageamento por Ressonância Magnética/instrumentação , Monitoramento de Radiação/instrumentação , Processamento de Sinais Assistido por Computador/instrumentação , Transdutores , Desenho de Equipamento , Análise de Falha de Equipamento , Campos Magnéticos , Imageamento por Ressonância Magnética/métodos , Doses de Radiação , Monitoramento de Radiação/métodos , Ondas de RádioRESUMO
PURPOSE: MR imaging and spectroscopy require a highly stable, uniform background field. The field stability is typically limited by hardware imperfections, external perturbations, or field fluctuations of physiological origin. The purpose of the present work is to address these issues by introducing spatiotemporal field stabilization based on real-time sensing and feedback control. METHODS: An array of NMR field probes is used to sense the field evolution in a whole-body MR system concurrently with regular system operation. The field observations serve as inputs to a proportional-integral controller that governs correction currents in gradient and higher-order shim coils such as to keep the field stable in a volume of interest. RESULTS: The feedback system was successfully set up, currently reaching a minimum latency of 20 ms. Its utility is first demonstrated by countering thermal field drift during an EPI protocol. It is then used to address respiratory field fluctuations in a T2 *-weighted brain exam, resulting in substantially improved image quality. CONCLUSION: Feedback field control is an effective means of eliminating dynamic field distortions in MR systems. Third-order spatial control at an update time of 100 ms has proven sufficient to largely eliminate thermal and breathing effects in brain imaging at 7 Tesla.
Assuntos
Encéfalo/anatomia & histologia , Aumento da Imagem/instrumentação , Aumento da Imagem/métodos , Imageamento por Ressonância Magnética/instrumentação , Imageamento por Ressonância Magnética/métodos , Sistemas Computacionais , Desenho de Equipamento , Análise de Falha de Equipamento , Retroalimentação , Imagens de Fantasmas , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Análise Espaço-TemporalRESUMO
PURPOSE: Magnetic field fluctuations caused by subject motion, such as breathing or limb motion, can degrade image quality in brain MRI, especially at high field strengths. The purpose of this study was to investigate the feasibility of retrospectively correcting for such physiological field perturbations based on concurrent field monitoring. THEORY AND METHODS: High-resolution T2*-weighted gradient-echo images of the brain were acquired at 7T with subjects performing different breathing and hand movement patterns. Field monitoring with a set of (19) F NMR probes distributed around the head was performed in two variants: concurrently with imaging or as a single field measurement per readout. The measured field fluctuations were then accounted for in the image reconstruction. RESULTS: Significant field fluctuations due to motion were observed in all subjects, resulting in severe artifacts in uncorrected images. The artifacts were largely removed by reconstruction based on field monitoring. Accounting for field perturbations up to the 1st spatial order was generally sufficient to recover good image quality. CONCLUSIONS: It has been demonstrated that artifacts due to physiologically induced dynamic field perturbations can be greatly reduced by retrospective image correction based on field monitoring. The necessity to perform such correction is greatest at high fields and for field-sensitive techniques such as T2*-weighted imaging.
Assuntos
Artefatos , Encéfalo/anatomia & histologia , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/métodos , Imagem Cinética por Ressonância Magnética/métodos , Imageamento por Ressonância Magnética/métodos , Espectroscopia de Ressonância Magnética/métodos , Adulto , Feminino , Humanos , MasculinoRESUMO
PURPOSE: Sinusoidal gradient oscillations in the kilohertz range are proposed for position tracking of NMR probes and prospective motion correction for arbitrary imaging sequences without any alteration of sequence timing. The method is combined with concurrent field monitoring to robustly perform image reconstruction in the presence of potential dynamic field deviations. METHODS: Benchmarking experiments were done to assess the accuracy and precision of the method and to compare it with theoretical predictions based on the field probe's time-dependent signal-to-noise ratio. An array of four field probes was used to perform real-time prospective motion correction in vivo. Images were reconstructed based on both predetermined and concurrently measured k-space trajectories. RESULTS: For observation windows of 4.8 ms, the precision of probe position determination was found to be 35 to 62 µm, and the maximal measurement error was 595 µm root-mean-square on a single axis. Sequence update per repetition time on this basis yielded images free of conspicuous artifacts despite substantial head motion. Predetermined and concurrently observed k-space trajectories yielded equivalent image quality. CONCLUSION: NMR field probes in conjunction with gradient tones permit the tracking and prospective correction of rigid-body motion. Relying on gradient oscillations in the kilohertz range, the method allows for concurrent motion detection and image encoding.
Assuntos
Movimentos da Cabeça/fisiologia , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Algoritmos , Humanos , Imagens de FantasmasRESUMO
PURPOSE: Diffusion MRI is compromised by unknown field perturbation during image encoding. The purpose of this study was to address this problem using the recently described approach of concurrent magnetic field monitoring. METHODS: Magnetic field dynamics were monitored during the echo planar imaging readout of a common diffusion-weighted MRI sequence using an integrated magnetic field camera setup. The image encoding including encoding changes over the duration of entire scans were quantified and analyzed. Field perturbations were corrected by accounting for them in generalized image reconstruction. The impact on image quality along with geometrical congruence among different diffusion-weighted images was assessed both qualitatively and quantitatively. RESULTS: The most significant field perturbations were found to be related to higher-order eddy currents from diffusion-weighting gradients and B0 field drift as well as gradual changes of short-term eddy current behavior and mechanical oscillations during the scan. All artifacts relating to dynamic field perturbations were eliminated by incorporating the measured encoding in image reconstruction. CONCLUSION: Concurrent field monitoring combined with generalized reconstruction enhances depiction fidelity in diffusion imaging. In addition to artifact reduction, it improves geometric congruence and thus facilitates image combination for quantitative diffusion analysis.
Assuntos
Imagem de Difusão por Ressonância Magnética/métodos , Imagem de Tensor de Difusão/métodos , Processamento de Imagem Assistida por Computador/métodos , Adulto , Algoritmos , Artefatos , Encéfalo/anatomia & histologia , Feminino , Humanos , Campos Magnéticos , Imagens de Fantasmas , Temperatura , Adulto JovemRESUMO
We introduce matched-filter fMRI, which improves BOLD (blood oxygen level dependent) sensitivity by variable-density image acquisition tailored to subsequent image smoothing. Image smoothing is an established post-processing technique used in the vast majority of fMRI studies. Here we show that the signal-to-noise ratio of the resulting smoothed data can be substantially increased by acquisition weighting with a weighting function that matches the k-space filter imposed by the smoothing operation. We derive the theoretical SNR advantage of this strategy and propose a practical implementation of 2D echo-planar acquisition matched to common Gaussian smoothing. To reliably perform the involved variable-speed trajectories, concurrent magnetic field monitoring with NMR probes is used. Using this technique, phantom and in vivo measurements confirm reliable SNR improvement in the order of 30% in a "resting-state" condition and prove robust in different regimes of physiological noise. Furthermore, a preliminary task-based visual fMRI experiment equally suggests a consistent BOLD sensitivity increase in terms of statistical sensitivity (average t-value increase of about 35%). In summary, our study suggests that matched-filter acquisition is an effective means of improving BOLD SNR in studies that rely on image smoothing at the post-processing level.
Assuntos
Interpretação Estatística de Dados , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Adulto , Sensibilidades de Contraste/fisiologia , Humanos , Razão Sinal-Ruído , Córtex Visual/fisiologiaRESUMO
PURPOSE: Magnetic resonance spectroscopy (MRS) experiments rely on a homogeneous and stable magnetic field within the sample. Field homogeneity is typically optimized by static B0 shimming while reproducible effects from dynamic field variation are commonly diminished by means of gradient system calibration as well as calibration based on non-water suppressed reference data. However, residual encoding deficiencies from incomplete calibration and nonreproducible field perturbations deteriorate the quality of the obtained data. To overcome this problem, we propose to adapt higher-order feedback field control based on NMR field probes for its application in MRS. METHODS: To allow for field measurements simultaneously with the spectroscopy readout, radiofrequency-shielded field probes were employed. The setup was evaluated in vitro and tested in vivo for single-voxel MRS at 7T to correct for field perturbations that occur due to subject breathing and limb motion. RESULTS: The in vitro experiments showed an effective field control during the MRS sequence. The resulting spectroscopy data were free of spurious signal and the achieved field stabilization improved the spectral resolution in vitro and in vivo. CONCLUSION: High-field MRS is limited by nonreproducible field perturbations for which spatiotemporal field feedback provides a solution without compromising sequence timing and efficiency.
Assuntos
Algoritmos , Artefatos , Espectroscopia de Prótons por Ressonância Magnética/instrumentação , Espectroscopia de Prótons por Ressonância Magnética/métodos , Processamento de Sinais Assistido por Computador/instrumentação , Desenho de Equipamento , Análise de Falha de Equipamento , Retroalimentação , Reprodutibilidade dos Testes , Sensibilidade e EspecificidadeRESUMO
PURPOSE: Applications of dynamic shimming require high field fidelity, and characterizing the shim field dynamics is therefore necessary. Modeling the system as linear and time-invariant, the purpose of this work was to measure the impulse response function with optimal sensitivity. THEORY AND METHODS: Frequency-swept pulses as inputs are analyzed theoretically, showing that the sweep speed is a key factor for the measurement sensitivity. By adjusting the sweep speed it is possible to achieve any prescribed noise profile in the measured system response. Impulse response functions were obtained for the third-order shim system of a 7 Tesla whole-body MR scanner. Measurements of the shim fields were done with a dynamic field camera, yielding also cross-term responses. RESULTS: The measured shim impulse response functions revealed system characteristics such as response bandwidth, eddy currents and specific resonances, possibly of mechanical origin. Field predictions based on the shim characterization were shown to agree well with directly measured fields, also in the cross-terms. CONCLUSION: Frequency sweeps provide a flexible tool for shim or gradient system characterization. This may prove useful for applications involving dynamic shimming by yielding accurate estimates of the shim fields and a basis for setting shim pre-emphasis.
Assuntos
Algoritmos , Interpretação de Imagem Assistida por Computador/instrumentação , Interpretação de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/instrumentação , Imageamento por Ressonância Magnética/métodos , Desenho de Equipamento , Análise de Falha de Equipamento , Imagens de Fantasmas , Reprodutibilidade dos Testes , Sensibilidade e EspecificidadeRESUMO
PURPOSE: To assess possible association between intrinsic structural damage and clinical disability by correlating spinal cord diffusion-tensor (DT) imaging data with electrophysiological parameters in patients with a diagnosis of multiple sclerosis (MS). MATERIALS AND METHODS: This study was approved by the local ethical committee according to the declaration of Helsinki and written informed consent was obtained. DT images and T1- and T2-weighted images of the spinal cord were acquired in 28 healthy volunteers and 41 MS patients. Fractional anisotropy (FA) and apparent diffusion coefficients were evaluated in normal-appearing white matter (NAWM) at the cervical level and were correlated with motor-evoked potentials (n = 34). Asymmetry index was calculated for FA values with corresponding left and right regions of interest as percentage of the absolute difference between these values relative to the sum of the respective FA values. Statistical analysis included Spearman rank correlations, Mann-Whitney test, and reliability analysis. RESULTS: Healthy volunteers had low asymmetry index (1.5%-2.2%). In MS patients, structural abnormalities were reflected by asymmetric decrease of FA (asymmetry index: 3.6%; P = .15). Frequently asymmetrically affected among MS patients was left and right central motor conduction time (CMCT) to abductor digiti minimi muscle (ADMM) (asymmetry index, 15%-16%) and tibialis anterior muscle (TAM) (asymmetry index, 9.5%-14.1%). Statistically significant correlations of functional (ie, electrophysiological) and structural (ie, DT imaging) asymmetries were found (P = .005 for CMCT to ADMM; P = .007 for CMCT to TAM) for the cervical lateral funiculi, which comprise the crossed pyramidal tract. Interobserver reliability for DT imaging measurements was excellent (78%-87%). CONCLUSION: DT imaging revealed asymmetric anatomic changes in spinal cord NAWM, which corresponded to asymmetric electrophysiological deficits for both arms and legs, and reflected a specific structure-function relationship in the human spinal cord.
Assuntos
Imagem de Tensor de Difusão/métodos , Potencial Evocado Motor , Esclerose Múltipla/patologia , Esclerose Múltipla/fisiopatologia , Medula Espinal/patologia , Medula Espinal/fisiopatologia , Adulto , Anisotropia , Braço/fisiopatologia , Estudos de Casos e Controles , Meios de Contraste , Feminino , Humanos , Perna (Membro)/fisiopatologia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Estatísticas não ParamétricasRESUMO
This work demonstrates a fast, sensitive method of characterizing the dynamic performance of MR gradient systems. The accuracy of gradient time-courses is often compromised by field imperfections of various causes, including eddy currents and mechanical oscillations. Characterizing these perturbations is instrumental for corrections by pre-emphasis or post hoc signal processing. Herein, a gradient chain is treated as a linear time-invariant system, whose impulse response function is determined by measuring field responses to known gradient inputs. Triangular inputs are used to probe the system and response measurements are performed with a dynamic field camera consisting of NMR probes. In experiments on a whole-body MR system, it is shown that the proposed method yields impulse response functions of high temporal and spectral resolution. Besides basic properties such as bandwidth and delay, it also captures subtle features such as mechanically induced field oscillations. For validation, measured response functions were used to predict gradient field evolutions, which was achieved with an error below 0.2%. The field camera used records responses of various spatial orders simultaneously, rendering the method suitable also for studying cross-responses and dynamic shim systems. It thus holds promise for a range of applications, including pre-emphasis optimization, quality assurance, and image reconstruction.