Detalhe da pesquisa
1.
Targeted protein degradation via intramolecular bivalent glues.
Nature
; 627(8002): 204-211, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-38383787
2.
Fast-acting chemical tools to delineate causality in transcriptional control.
Mol Cell
; 81(8): 1617-1630, 2021 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33689749
3.
Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo.
Mol Cell
; 81(15): 3096-3109.e8, 2021 08 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34146481
4.
Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation.
Mol Cell
; 75(4): 849-858.e8, 2019 08 22.
Artigo
Inglês
| MEDLINE | ID: mdl-31442425
5.
Design principles for cyclin K molecular glue degraders.
Nat Chem Biol
; 20(1): 93-102, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-37679459
6.
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders.
Nat Chem Biol
; 19(3): 323-333, 2023 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36329119
7.
BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.
Mol Cell
; 67(1): 5-18.e19, 2017 Jul 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28673542
8.
Discovery of a DCAF11-dependent cyanoacrylamide-containing covalent degrader of BET-proteins.
Bioorg Med Chem Lett
; 107: 129779, 2024 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38729317
9.
Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders.
Angew Chem Int Ed Engl
; 63(12): e202316730, 2024 Mar 18.
Artigo
Inglês
| MEDLINE | ID: mdl-38153885
10.
Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence.
J Am Chem Soc
; 145(5): 2711-2732, 2023 02 08.
Artigo
Inglês
| MEDLINE | ID: mdl-36706315
11.
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance.
J Am Chem Soc
; 145(2): 1176-1184, 2023 01 18.
Artigo
Inglês
| MEDLINE | ID: mdl-36602777
12.
Transcription control by the ENL YEATS domain in acute leukaemia.
Nature
; 543(7644): 270-274, 2017 03 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28241139
13.
Rational discovery of molecular glue degraders via scalable chemical profiling.
Nat Chem Biol
; 16(11): 1199-1207, 2020 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32747809
14.
BRD4 degradation blocks expression of MYC and multiple forms of stem cell resistance in Ph+ chronic myeloid leukemia.
Am J Hematol
; 97(9): 1215-1225, 2022 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35794848
15.
Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.
Mol Cell
; 55(2): 277-90, 2014 Jul 17.
Artigo
Inglês
| MEDLINE | ID: mdl-24981170
16.
Proximity-inducing pharmacology.
Nat Chem Biol
; 20(1): 13-14, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-37978259
17.
Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma.
Proc Natl Acad Sci U S A
; 115(22): E5086-E5095, 2018 05 29.
Artigo
Inglês
| MEDLINE | ID: mdl-29764999
18.
19.
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
Nat Chem Biol
; 14(4): 405-412, 2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29507391
20.
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
Nat Chem Biol
; 14(2): 163-170, 2018 02.
Artigo
Inglês
| MEDLINE | ID: mdl-29251720