RESUMO
This study investigated the effects of MRI on receptor-mediated activation of pineal gland indole biosynthesis. Exposure of rats to MRI reduced the effects of isoproterenol on pineal serotonin and N-acetylserotonin levels suggesting that strong magnetic fields and/or radio-frequency pulsing used in MRI inhibited beta-adrenergic activation of the gland. There was no effect of MRI on saline controls.
Assuntos
Campos Eletromagnéticos , Fenômenos Eletromagnéticos , Imageamento por Ressonância Magnética , Glândula Pineal/fisiologia , Receptores Adrenérgicos beta/fisiologia , Serotonina/metabolismo , Animais , Isoproterenol/farmacologia , Masculino , Glândula Pineal/metabolismo , Ratos , Ratos Endogâmicos , Receptores Adrenérgicos beta/efeitos dos fármacosRESUMO
Thirteen patients with clinical stages I and II endometrial carcinoma were examined with magnetic resonance (MR) imaging before surgery. Depth of invasion and stage of disease were assessed, and the results were compared with those from MR images of the surgical specimens and pathologic findings. Staging with MR imaging was accurate in 11 of 13 patients (85%). Our results agree with previous reports that MR imaging is an accurate, noninvasive method of assessing depth of myometrial invasion and cervical involvement. We anticipate that MR imaging will have an increasing role in treatment of patients with endometrial carcinoma.