Detalhe da pesquisa
1.
A general strategy exploiting m5C duplex-remodelling effect for selective detection of RNA and DNA m5C methyltransferase activity in cells.
Nucleic Acids Res
; 48(1): e5, 2020 01 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31691820
2.
Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity.
Biochem Biophys Res Commun
; 479(3): 476-481, 2016 Oct 21.
Artigo
Inglês
| MEDLINE | ID: mdl-27651333
3.
Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro.
Bioorg Med Chem
; 23(17): 5891-908, 2015 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26189030
4.
Synergistic combination of antimicrobial peptide and isoniazid as inhalable dry powder formulation against multi-drug resistant tuberculosis.
Int J Pharm
; 654: 123960, 2024 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-38447778
5.
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep
; 12(5): 463-9, 2011 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21460794
6.
Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
Org Biomol Chem
; 11(5): 732-745, 2013 Feb 07.
Artigo
Inglês
| MEDLINE | ID: mdl-23151668
7.
One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.
Bioorg Med Chem
; 21(17): 5218-27, 2013 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23849206
8.
Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets.
J Med Chem
; 64(23): 16974-17003, 2021 12 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34792334
9.
Observations on the deprotection of pinanediol and pinacol boronate esters via fluorinated intermediates.
J Org Chem
; 75(2): 468-71, 2010 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20014787
10.
Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells.
Nanoscale
; 12(35): 18022-18030, 2020 Sep 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32857097
11.
A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N 6-methyladenosine demethylase activity in cells.
Chem Sci
; 9(36): 7174-7185, 2018 Sep 28.
Artigo
Inglês
| MEDLINE | ID: mdl-30288236
12.
Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily-Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3.
Chem Asian J
; 13(19): 2854-2867, 2018 Oct 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29917331
13.
Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.
Angew Chem Int Ed Engl
; 51(27): 6672-5, 2012 Jul 02.
Artigo
Inglês
| MEDLINE | ID: mdl-22639232
14.
Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.
Angew Chem Int Ed Engl
; 51(7): 1631-4, 2012 Feb 13.
Artigo
Inglês
| MEDLINE | ID: mdl-22241642
15.
A methylation-switchable conformational probe for the sensitive and selective detection of RNA demethylase activity.
Chem Commun (Camb)
; 52(36): 6181-4, 2016 05 04.
Artigo
Inglês
| MEDLINE | ID: mdl-27074833
16.
N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5.
Sci Rep
; 6: 25677, 2016 05 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27156733
17.
Poly(ADP-ribose)polymerase inhibition - where now?
Curr Med Chem
; 12(20): 2373-92, 2005.
Artigo
Inglês
| MEDLINE | ID: mdl-16181138
18.
A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO.
Chem Sci
; 6(1): 112-122, 2015 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28553460
19.
A safe lithium mimetic for bipolar disorder.
Nat Commun
; 4: 1332, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23299882
20.
Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.
J Med Chem
; 55(5): 2173-84, 2012 Mar 08.
Artigo
Inglês
| MEDLINE | ID: mdl-22263962