Detalhe da pesquisa
1.
Practical synthesis of capromorelin, a growth hormone secretagogue, via a crystallization-induced dynamic resolution.
Bioorg Med Chem
; 25(3): 1000-1003, 2017 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28012686
2.
Discovery of a novel Kv7 channel opener as a treatment for epilepsy.
Bioorg Med Chem Lett
; 25(21): 4941-4944, 2015 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25987375
3.
Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation.
Bioorg Med Chem Lett
; 19(7): 2075-8, 2009 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19250823
4.
Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.
ACS Med Chem Lett
; 9(2): 68-72, 2018 Feb 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29456790
5.
Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.
J Med Chem
; 60(18): 7764-7780, 2017 09 28.
Artigo
Inglês
| MEDLINE | ID: mdl-28817277
6.
Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.
J Med Chem
; 57(3): 861-77, 2014 Feb 13.
Artigo
Inglês
| MEDLINE | ID: mdl-24392688
7.
Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin.
Bioorg Med Chem
; 11(4): 581-90, 2003 Feb 20.
Artigo
Inglês
| MEDLINE | ID: mdl-12538023
8.
Discovery and biological characterization of capromorelin analogues with extended half-lives.
Bioorg Med Chem Lett
; 12(22): 3279-82, 2002 Nov 18.
Artigo
Inglês
| MEDLINE | ID: mdl-12392732