RESUMO
The aim of this study was to measure omentin-1 concentrations in serum and synovial fluid (SF) of knee osteoarthritis (OA) patients and to investigate their correlation with patient-reported symptomatic severity. We enrolled 263 knee OA patients and 62 healthy controls. We collected Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores from OA patients and measured omentin-1 concentrations in serum and SF by enzyme-linked immunosorbent assay (ELISA). Our results demonstrated that omentin-1 concentrations in SF but not serum were independently and negatively correlated with self-reported greater pain and physical disability in OA patients. Omentin-1 in SF might serve as a potential biomarker for reflecting the symptomatic severity of OA.
Assuntos
Citocinas/metabolismo , Lectinas/metabolismo , Osteoartrite do Joelho/metabolismo , Osteoartrite do Joelho/patologia , Índice de Gravidade de Doença , Líquido Sinovial/metabolismo , Idoso , Citocinas/sangue , Citocinas/líquido cefalorraquidiano , Feminino , Proteínas Ligadas por GPI/sangue , Proteínas Ligadas por GPI/líquido cefalorraquidiano , Proteínas Ligadas por GPI/metabolismo , Humanos , Lectinas/sangue , Lectinas/líquido cefalorraquidiano , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Osteoartrite do Joelho/sangue , Osteoartrite do Joelho/líquido cefalorraquidianoRESUMO
The polymorphism of the vascular endothelial growth factor (VEGF) -634C/G has been correlated with susceptibility to osteonecrosis of the femoral head (ONFH). The aim of this study was to derive a more precise estimation of the relationship between the VEGF -634C/G polymorphism and ONFH by performing a meta-analysis. We searched articles indexed in Pubmed, OVID and Web of Science published up to January 2015 that met our predefined criteria. The strength of the association between VEGF -634C/G polymorphism and ONFH risk was assessed by an odds ratio (OR) with the corresponding 95% CI. Three eligible studies involving 692 cases and 875 controls were identified. Overall, pooled analysis indicated a significant association between VEGF -634C/G polymorphism and ONFH risk (for C vs. G: OR=1.141, 95% CI 1.055-1.235, P=0.001; for CC vs. GG: OR=1.345, 95% CI 1.124-1.610, P=0.001; for CG vs. GG: OR=1.106, 95% CI 1.018-1.202, P=0.017; for CG+CC vs. GG: OR=1.104, 95% CI 1.035-1.177, P=0.003; for CC vs. GG+ CG: OR=1.294, 95% CI 1.051-1.593, P=0.015). No evidence of publication bias was observed. In conclusion, this meta-analysis suggested that polymorphism of VEGF -634C/G was a risk factor for ONFH. This finding needs further confirmation by trans-regional multicenter study with large sample in different ethnic populations, such as Caucasian and Austroloid.