Mechanism of hepatocyte growth factor in childhood respiratory diseases / 中华实用儿科临床杂志

Hepatocyte growth factor (HGF) is a mesenchymal-derived growth factor, which is widely used in the basic and clinical research of pediatric multi-system due to various biological functions.As a protective factor for lung tissues, HGF has significant biological effects on enhancing lung tissue development, stimulating DNA production of lung epithelial cells, repairing lung microvascular endothelial cells, inhibiting apoptosis induced by lung injury, and delaying pulmonary fibrosis.HGF is closely related to the occurrence and development of respiratory diseases in children.This study aims to review the physiological characteristics of HGF and the mechanism in children′s respiratory diseases.

Treatment compliance and uric acid control rate in patients with primary gout / 中华全科医师杂志

Objective To investigate the treatment compliance and uric acid control rate in patients with primary gout.Methods One hundred primary gout patients with disease duration ＞ 6 months treated in our hospital from June 2015 to June 2016 were enrolled in the study.The treatment compliance and disease control rate were evaluated with revised Chinese Compliance Questionnaire-Rheumatology (CCQR).Results Eighty four valid questionnaires was recovered for analysis.Among 84 patients there were 46 cases of high compliance (54.8％) and 38 cases of poor compliance (45.2％).The CCQR score in high compliance group was significantly higher than that in poor compliance group (73.48 ± 15.62 vs.48.37 ±10.96,t =8.352,P ＜ 0.001).There were no significant differences in education level,personal income,family history,health insurance and type of uric-acid-lowering drugs between high compliance group and low compliance group (P ＞ 0.05).The duration of gout was shorter in high compliance group than that in low compliance group [(6.12 ± 1.79) y vs.(13.24 ± 4.56) y,P ＜ 0.001].The uric acid control rate in high compliance group was higher than that in poor compliance group (76.1％ vs.36.8％,x2 =13.186,P =0.000 3);and the serum uric acid levels were (369.82 ± 35.67)μmol/L and (497.46 ± 63.49)μmol/L in two groups,respectively (t =11.606,P ＜ 0.001).Conclusion It is necessary to strengthen health education for gout patients to improve the treatment compliance and to achieve the high uric acid control rate.

Effects of Rehmanniae Radix Preparata and Poria on decoction amounts of three constituents in Corni Fructus / 中成药

AIM To study the effects of Rehmanniae Radix Preparata (A) and Poria (B) on decoction amounts of loganin,morroniside and 5-hydroxymethylfurfural in Corni Fructus (C).METHODS These three medicinal materials were combined one another and divided into seven groups (A,B,C,A + B,A + C,B + C and A + B + C).Then the contents of three constituents were determined by HPLC.RESULTS Compared with the single decoction of Corni Fructus,the decoction amounts of loganin and 5-hydroxymethylfurfural were decreased,and that of morroniside was increased at the time of mixed decoction of Rehmanniae Radix Preparata and Corni Fructus,or Rehmanniae Radix Preparata,Poria and Corni Fructus.This situation was just the contrary at the time of mixed decoction of Poria and Corni Fructus.CONCLUSION The mixed decoction of Corni Fructus,Rehmanniae Radix Preparata and Poria increases the decoction amount of morroniside,which may make mixed decoction liquid show better efficacy.

Effects of Combined Decoctions of Alismatis Rhizoma and Curcumae Radix and Rehmanniae Radix Praeparata on the Decoction Amount of Acteoside in Rehmanniae Radix Praeparata / 中国药房

OBJECTIVE:To study the effects of combined decoctions of alismatis rhizoma and curcumae radix and rehmanniae radix praeparata on the decoction amount of acteoside in rehmanniae radix praeparata,and provide reference for studying the effec-tive ingredients of three-drug effect. METHODS:Single decoction-1(rehmanniae radix praeparata 20 g),single decoction-2(alis-matis rhizoma 20 g),single decoction-3(curcumae radix 20 g),combined decoction-1(rehmanniae radix praeparata 20 g,alisma-tis rhizoma 20 g),combined decoction-2(rehmanniae radix praeparata 20 g,curcumae radix 20 g),combined decoction-3(alisma-tis rhizoma 20 g,curcumae radix 20 g)and combined decoction-4(rehmanniae radix praeparata 20 g,alismatis rhizoma 20 g,cur-cumae radix 20 g)were respectively taken to prepare dry extracts after extracting by refluxing,HPLC was used to detect the acteo-side content and calculate its decoction amount in sample. RESULTS:The decoction amounts of acteoside in single decoction-1, combined decoction-1,combined decoction-2 and combined decoction-4 dry extracts were 0.0354,0.0223,0.0228,0.0110 mg/g,respectively. Compared with single decoction-1 group,the last 3 groups had statistical significances(P<0.01);combined decoc-tion-4 showed lowest decoction amount in three-drug combined decoction group. Acteoside was not detected in the negative control groups(single decoction-2,single decoction-3 and combined decoction-3). CONCLUSIONS:The decoction amount of acteoside is reduced when alismatis rhizoma,curcumae radix and rehmanniae radix praeparata were decocted together,indicating that it may not be the main ingredient of playing effects in three-drug combined decoction liquid.

Effect of fluvastatin sodium on the risk factors of atherosclerosis in previous coronary heart disease after infection with chlamydia pneumonia / 中国生化药物杂志

Objective To investigate the effect of fluvastatin sodium on the risk factors of atherosclerosis in patients with previous coronary heart disease.Methods 58 cases meeting the inclusion criteria and diagnosed coronary heart disease history of chlamydial infection were selected and randomly divided into study group and control group, 29 cases in each group, the control group were given routine treatment, study group on the basis of conventional treatment of fluvastatin sodium(20 mg pertime, once daily) treatment.A total of 4 weeks treatment for a course, the blood lipid and vascular endothelial function, matrix metalloproteinases and inflammatory factor levels were determined before and after treatment, and adverse reactions were recorded between the two groups.Results Compared with the control group, the total cholesterol ( TC ) , triglyceride ( TG ) , low density lipoprotein cholesterol(LDL-C) and lipid comprehensive index(LCI) in study group after treatment were lower, the high density lipid-cholesterol(HDL-C) was higher, the soluble intercellular adhesion molecule-1(sI-CAM-1) and endothelin-1(ET-1) were lower, the NO was higher, matrix metalloproteinase-1 (MMP-1), MMP-9 and tissue inhibitor of metalloproteinase-1(TIMP-1) were lower, and tumor necrosis factor-α(TNF-α), interleukin 1 beta(IL-1β), high-sensitivity c-reactive protein( Hs-CRP ) and IL-6 were lower ( all P <0.05 ).All patients were followed up, only slight gastrointestinal adverse reaction, there was no significant difference in adverse reactions between the two groups.Conclusion The fluvastatin sodium can reduce the blood lipid, the level of matrix metalloproteinases, improve vascular endothelial function and inflammatory state, with high safety.

Risk factors of postoperative intravesical recurrence of transitional cell carcinoma of the ureter / 南方医科大学学报

<p><b>OBJECTIVE</b>To define the clinicopathological risk factors of intravesical recurrence of primary transitional cell carcinoma of the ureter after surgical intervention.</p><p><b>METHODS</b>Patients with primary carcinoma of the ureter treated between January 2000 and December 2010 were retrospectively analyzed. The intravesical recurrence-free survival rate was calculated using Kaplan-Meier method. Multivariate analysis was conducted with Cox's regression.</p><p><b>RESULTS</b>A total of 104 patients were enrolled, who were followed up for a median of 46 months (13-89 months). Thirty-nine of the patients showed postoperative intravesical recurrence. Urine exfoliative cytology (P=0.000), number of tumors (P=0.006), tumor grade (P=0.039) and co-existence of bladder tumor (P=0.014) were found to independently influence the postoperative intravesical recurrence. Patients with more risk factors had poorer intravesical recurrence-free survival.</p><p><b>CONCLUSION</b>Urine exfoliative cytology, number of tumors, tumor grade and co-existence of bladder tumor are independent risk factors for postoperative intravesical recurrence of primary transitional cell carcinoma of the ureter. Close follow-up and rigorous treatment are essential for patients with high risk factors.</p>