Detalhe da pesquisa
1.
Profiling of the chemical space on the phenyl group of substituted benzothiazole RIPK3 inhibitors.
Bioorg Chem
; 131: 106339, 2023 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36599218
2.
Opportunities and Challenges of Kava in Lung Cancer Prevention.
Int J Mol Sci
; 24(11)2023 May 31.
Artigo
Inglês
| MEDLINE | ID: mdl-37298489
3.
Characterization of adductomic totality of NNK, (R)-NNAL and (S)-NNAL in A/J mice, and their correlations with distinct lung carcinogenicity.
Carcinogenesis
; 43(2): 170-181, 2022 03 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34919675
4.
Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin prophylaxis of NNK-induced lung carcinogenesis.
Carcinogenesis
; 43(7): 659-670, 2022 08 30.
Artigo
Inglês
| MEDLINE | ID: mdl-35353881
5.
Characterization of Different Forms of Kava (Piper methysticum) Products by UPLC-MS/MS.
Planta Med
; 88(14): 1348-1359, 2022 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-34839465
6.
CXL146, a Novel 4H-Chromene Derivative, Targets GRP78 to Selectively Eliminate Multidrug-Resistant Cancer Cells.
Mol Pharmacol
; 97(6): 402-408, 2020 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32276963
7.
Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice.
Chem Res Toxicol
; 33(7): 1980-1988, 2020 07 20.
Artigo
Inglês
| MEDLINE | ID: mdl-32476407
8.
Design, synthesis, and enzymatic characterization of quinazoline-based CYP1A2 inhibitors.
Bioorg Med Chem Lett
; 30(2): 126719, 2020 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31784319
9.
Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease.
Bioorg Chem
; 103: 104172, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32890991
10.
Kava and its Kavalactones Inhibit Norepinephrine-induced Intracellular Calcium Influx in Lung Cancer Cells.
Planta Med
; 86(1): 26-31, 2020 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-31711251
11.
Chalcone: A Privileged Structure in Medicinal Chemistry.
Chem Rev
; 117(12): 7762-7810, 2017 Jun 28.
Artigo
Inglês
| MEDLINE | ID: mdl-28488435
12.
Contribution of Tobacco Use and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone to Three Methyl DNA Adducts in Urine.
Chem Res Toxicol
; 31(9): 836-838, 2018 09 17.
Artigo
Inglês
| MEDLINE | ID: mdl-30136842
13.
An Indole-Chalcone Inhibits Multidrug-Resistant Cancer Cell Growth by Targeting Microtubules.
Mol Pharm
; 15(9): 3892-3900, 2018 09 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30048137
14.
Autophagy-Mediated Degradation of IAPs and c-FLIP(L) Potentiates Apoptosis Induced by Combination of TRAIL and Chal-24.
J Cell Biochem
; 117(5): 1136-44, 2016 May.
Artigo
Inglês
| MEDLINE | ID: mdl-26448608
15.
Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles.
Biochem Biophys Res Commun
; 481(3-4): 206-211, 2016 Dec 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27815070
16.
Gene expression signatures associated with suppression of TRAMP prostate carcinogenesis by a kavalactone-rich Kava fraction.
Mol Carcinog
; 55(12): 2291-2303, 2016 12.
Artigo
Inglês
| MEDLINE | ID: mdl-26840761
17.
Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification.
Drug Metab Dispos
; 44(3): 422-7, 2016 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-26744252
18.
Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O6-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice.
Chem Res Toxicol
; 29(11): 1828-1834, 2016 11 21.
Artigo
Inglês
| MEDLINE | ID: mdl-27728767
19.
4H-Chromene-based anticancer agents towards multi-drug resistant HL60/MX2 human leukemia: SAR at the 4th and 6th positions.
Bioorg Med Chem
; 24(6): 1292-7, 2016 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26867486
20.
Characterization of the Fluorescence Properties of 4-Dialkylaminochalcones and Investigation of the Cytotoxic Mechanism of Chalcones.
Arch Pharm (Weinheim)
; 349(7): 539-52, 2016 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-27214789