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1.
J Minim Access Surg ; 13(1): 13-17, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-27934791

RESUMO

AIM: Single incision diagnostic laparoscopy (SIDL) may be an alternative procedure to multi-incision diagnostic laparoscopy (MDL) for penetrating thoracoabdominal stab wounds. The purpose of this study is sharing our experience and comparing two techniques for diaphragmatic status. MATERIALS AND METHODS: Medical records of 102 patients with left thoracoabdominal penetrating stab injuries who admitted to Istanbul School of Medicine, Trauma and Emergency Surgery Clinic between February 2012 and April 2016 were examined. The patients were grouped according to operation technique. Patient records were retrospectively reviewed for data including, age, sex, length of hospital stay, diaphragm injury rate, surgical procedure, operation time and operation time with wound repair, post-operative complications and accompanying injuries. RESULTS: The most common injury location was the left anterior thoracoabdomen. SIDL was performed on 26 patients. Nine (34.6%) of the 26 patients had a diaphragm injury. Seventy-six patients underwent MDL. Diaphragmatic injury was detected in 20 (26.3%) of 76 patients. The average operation time and post-operative complications were similar; there was no statistically significant difference between MDL and SIDL groups. CONCLUSION: SIDL can be used as a safe and feasible procedure in the repair of a diaphragm wounds. SIDL may be an alternative method in the diagnosis and treatment of these patients.

2.
Ulus Travma Acil Cerrahi Derg ; 20(1): 23-7, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24639311

RESUMO

BACKGROUND: In recent decades, the use of colorectal stents for palliation or as a bridge to surgery in acute malignant colorectal obstruction has increased. We aimed to evaluate the technical and clinical efficacy, safety and clinical outcomes of endoscopic stenting for the relief of acute colorectal obstruction secondary to cancer. METHODS: From March 2006 to December 2012, among 100 patients with acute malignant colorectal obstruction, stenting procedures were performed on 42 patients for relief of obstruction. Uncovered self-expanding metal stents (SEMS) were placed endoscopically under fluoroscopic guidance in all patients. Using the patient database, a review was conducted to determine the effectiveness of the procedure and the short- and long-term complications. RESULTS: Stent placement was technically successful in 39/42 (92.8%) and clinically successful in 38/42 (90.4%) patients. Sixteen patients later underwent an elective surgical resection, and in 26 patients with metastatic disease or comorbidity, stent placement was palliative. Complications occurred in 10 (23.8%) patients, and the most common was tenesmus (n=3). Migration, bleeding, and recto-sigmoid perforation occurred in two patients each. Stent obstruction due to fecal impaction was seen in one case. CONCLUSION: Stent placement for colorectal obstruction is an effective and relatively safe procedure, with minor complications. It not only allows subsequent elective resection, but is also definitive for palliative treatment in patients with obstructive colorectal cancer.


Assuntos
Neoplasias Colorretais/cirurgia , Obstrução Intestinal/cirurgia , Stents , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias Colorretais/complicações , Humanos , Obstrução Intestinal/etiologia , Pessoa de Meia-Idade , Estudos Retrospectivos
3.
Arch Gynecol Obstet ; 288(6): 1275-8, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23715923

RESUMO

BACKGROUND: The current guidelines recommend endoscopic retrograde cholangiopancreatography (ERCP) procedures in pregnant women with minimal radiation exposure. Regarding the safety of ERCP during pregnancy, data are limited in the literature. In this study, we report our experience with five ERCP procedures performed in five pregnant women without radiation at a single tertiary health center. METHODS: Between May 2007 and February 2012, five pregnant patients underwent ERCP without radiation, analyzed retrospectively. Clinical disease was confirmed with either pre-procedure ultrasonography and magnetic resonance cholangiopancreatography in all patients. In all cases, selective deep cannulation was performed and confirmed by the aspiration and/or direct visualization of the bile. The data regarding laboratory, ultrasonography, magnetic resonance imaging, endoscopic findings, and clinical course of the patients were analyzed. Fetal complications were noted at delivery and 30 days postdelivery follow-up. RESULTS: The mean patient age was 26 years (22-33) and the mean duration of pregnancy was 20 weeks (12-32). In all cases, no secondary ERCP procedures were needed. Also, no maternal and fetal adverse events and complications were determined after the procedures or on follow-up. All stages of the procedure including cannulation, sphincterotomy, and stone extraction were performed without the use of fluoroscopy. CONCLUSION: As far we know, there is no report in the literature regarding the failure of endoscopic retraction of stones without fluoroscopy during pregnancy. Our series notes that ERCP is safe and prevents recurrent biliary pancreatitis during pregnancy. Unfortunately, due to the small limited number of patient data, our study notes the requirement of further large randomized and controlled series.


Assuntos
Colangiopancreatografia Retrógrada Endoscópica/métodos , Colangite/diagnóstico , Coledocolitíase/cirurgia , Pancreatite/complicações , Complicações na Gravidez/cirurgia , Adulto , Colangite/terapia , Coledocolitíase/complicações , Feminino , Idade Gestacional , Humanos , Imageamento por Ressonância Magnética , Pancreatite/cirurgia , Gravidez , Complicações na Gravidez/diagnóstico , Resultado da Gravidez , Gravidez de Alto Risco , Estudos Retrospectivos , Resultado do Tratamento
4.
Toxicol Mech Methods ; 23(4): 235-9, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23193993

RESUMO

Colorectal cancer is among the most common cancer types in the world and its etiology involves the interaction of genetic and environmental factors. ABCB1 is highly expressed in the apical surface of colonic epithelial cells and acts as an efflux pump by transporting toxic endogenous substances, drugs and xenobiotics out of cells. ABCB1 polymorphisms may either change its protein expression or alter its function. Several studies have reported a possible association between ABCB1 variants and colorectal cancer, but no consistent conclusion has been arrived at. Therefore, we aimed to investigate the relationship between colorectal cancer and the functional common variants of ABCB1 (1236C > T; 2677G > T/A; 3435C > T). The distributions of the variants were determined in 103 patients with colorectal cancer and 150 healthy volunteers using polymerase chain reaction-restriction fragment length polymorphism methods. ABCB1 1236C > T was statistically significantly associated with colorectal cancer risk (OR, odd ratio = 1.91; 95% CI, confidence interval = 1.09-3.35; p = 0.034). In haplotype-based analysis, the proportion of individuals with the ABCB1 haplotype C1236-G2677-T3435 was significantly more common in patients than in controls (OR = 11.96; 95% CI = 2.59-55.32; p = 0.0004). We believe that the findings may be beneficial to the development of efficacious preventive strategies and therapies for colorectal cancer.


Assuntos
Membro 1 da Subfamília B de Cassetes de Ligação de ATP/genética , Neoplasias Colorretais/genética , Predisposição Genética para Doença , Polimorfismo de Nucleotídeo Único , Subfamília B de Transportador de Cassetes de Ligação de ATP , Análise do Polimorfismo de Comprimento de Fragmentos Amplificados , Estudos de Casos e Controles , Neoplasias Colorretais/metabolismo , Neoplasias Colorretais/patologia , Feminino , Frequência do Gene , Testes Genéticos , Genótipo , Haplótipos , Humanos , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Risco , Turquia
5.
Turk Gogus Kalp Damar Cerrahisi Derg ; 31(1): 128-130, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36926152

RESUMO

The pinch-off syndrome is defined as the embolization of the central catheter inserted via the subclavian approach due to the mechanical compression between the clavicle, the first rib, the subclavius muscle, and the costoclavicular ligament. Embolization to the pulmonary artery is an extremely rare condition. In this article, we present a rare case with ovarian cancer who had multiple metastases both locally and lungs, the port catheter was fractured into three parts, the proximal part was removed, the middle part was left between the subclavian vein and the skin, and the long distal part was embolized to the pulmonary artery.

6.
Oncol Res ; 31(5): 689-696, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37547762

RESUMO

Radiation therapy (RT) is typically applied using one of two standard approaches for preoperative treatment of resectable locally advanced rectal cancer (LARC): short-course RT (SC-RT) alone or long-course RT (LC-RT) with concurrent fluorouracil (5-FU) chemotherapy. The Phase II single-arm KROG 11-02 study using intermediate-course (IC) (33 Gy (Gray)/10 fr (fraction) with concurrent capecitabine) preoperative chemoradiotherapy (CRT) demonstrated a pathologically complete response rate and a sphincter-sparing rate that were close to those of LC-CRT. The current trial aim to compare the pathological/oncological outcomes, toxicity, and quality of life results of LC-CRT and IC-CRT in cases of LARC. The prescribed dose was 33 Gy/10 fr for the IC-CRT group and 50.4 Gy/28 fr for the LC-CRT group. Concurrent chronomodulated capecitabine (Brunch regimen) 1650 mg/m2/daily chemotherapy treatment was applied in both groups. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer Module (EORTC QLQ-CR29) was administered at baseline and at three and six months after CRT. A total of 60 patients with LARC randomized to receive IC-CRT (n = 30) or LC-CRT (n = 30) were included in this phase II randomized trial. No significant difference was noted between groups in terms of pathological outcomes, including pathological response rates (ypT0N0-complete response: 23.3% vs. 16.7%, respectively, and ypT0-2N0-downstaging: 50% for each; p = 0.809) and Dworak score-based pathological tumor regression grade (Grade 4-complete response: 23.3 vs. 16.7%, p = 0.839). The 5-year overall survival (73.3 vs. 86.7%, p = 0.173) rate was also similar. The acute radiation dermatitis (p < 0.001) and any hematological toxicity (p = 0.004) rates were significantly higher in the LC-CRT group, while no significant difference was noted between treatment groups in terms of baseline, third month, and sixth month EORTC QLQ-CR29 scores.


Assuntos
Qualidade de Vida , Neoplasias Retais , Humanos , Capecitabina/efeitos adversos , Canal Anal/patologia , Terapia Neoadjuvante/métodos , Tratamentos com Preservação do Órgão , Neoplasias Retais/terapia , Neoplasias Retais/patologia , Fluoruracila , Quimiorradioterapia/efeitos adversos , Quimiorradioterapia/métodos , Estadiamento de Neoplasias , Resultado do Tratamento , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos
7.
Ulus Travma Acil Cerrahi Derg ; 18(1): 61-4, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22290052

RESUMO

BACKGROUND: We reviewed retrospectively TV-related injuries to determine the risk factors, type of injuries, and operative intervention(s) required in children injured by falling TVs. METHODS: This was a retrospective descriptive study conducted on 42 pediatric patients who were admitted to Istanbul University, Istanbul Medical Faculty, Emergency Surgery Department. Case notes included all demographic and injury details, TV and TV-related furniture type, mechanism of injury, Pediatric Trauma Score (PTS), Pediatric Glasgow Coma Scale (PGCS), length of hospital stay, need for intensive care unit assessments, and management plans. RESULTS: More than 65% of the children were aged 1 to 3 years. The injury rate was higher for boys (66.7%) than girls (33.3%). Of the 42 patients identified, 17 (40.5%) sustained only head injuries, with almost half of these having a definite traumatic brain injury; 6 (14.3%) had only thoracic injury, and 4 (9.5%) had only limb injury. The PGCS ranged from 3 to 15, with a mean of 7. The PTS ranged from -6 to 12, with a mean of 9. Five children (11.9%), all aged 2 years or younger, died in the hospital as a result of the TV-related injury, all sustaining head and thorax injuries, which are reflected in a significantly lower PTS and lower PGCS on admission compared with older children. TV falls on to children often occur because of unstable supports, with dressers and shelves being the most common. The most common mechanism of injury (71.4%) among all age groups was fall/tipping of furniture. Pulling the furniture onto oneself (19%) was the second most frequent mechanism of injury. CONCLUSION: Injuries related to TV falls can lead to significant morbidity and mortality in children. As they are preventable injuries, restricted activity and improved supervision of children around the TV can potentially lead to fewer incidences.


Assuntos
Acidentes Domésticos , Ferimentos não Penetrantes/epidemiologia , Adolescente , Criança , Pré-Escolar , Feminino , Escala de Coma de Glasgow , Traumatismos Cranianos Fechados/epidemiologia , Traumatismos Cranianos Fechados/patologia , Traumatismos Cranianos Fechados/prevenção & controle , Humanos , Escala de Gravidade do Ferimento , Tempo de Internação , Masculino , Estudos Retrospectivos , Televisão , Turquia/epidemiologia , Ferimentos não Penetrantes/patologia , Ferimentos não Penetrantes/prevenção & controle
8.
Ulus Travma Acil Cerrahi Derg ; 18(3): 225-30, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22864714

RESUMO

BACKGROUND: We aimed to evaluate the role of Tc-99m labeled red blood cell (RBC) scintigraphy for determination of localization of gastrointestinal system (GIS) bleeding. METHODS: Fifty-seven cases (27 females, 30 males; mean age 43.9±24; range 1 to 91 years) who referred to our clinic between 1995-2010 were evaluated for determination of localization of GIS bleeding with RBC scintigraphy. Prior to scintigraphy, gastroscopy in 51, colonoscopy in 45, and angiography in 9 patients were performed. RESULTS: RBC scintigraphies were positive and negative in 31 and 26 patients, respectively. Positive scintigraphic findings were obtained within the 1st hour of dynamic imaging in 19 patients, within the 1st-4th hour static images in 7, and within the 4th-24th hour images in 5 patients. Fourteen patients underwent surgical exploration. In 13 patients, the surgery confirmed the diagnosis by RBC scintigraphy (accuracy: 92.8%). Of 43 patients without surgical exploration, 12 had anemia due to iron deficiency and their scintigraphic evaluation were negative. Four patients died and in 27 patients, GIS bleeding ceased spontaneously or with conservative measures. CONCLUSION: Scintigraphy should be the primary tool for accurate diagnosis of patients with active GIS bleeding. Positive dynamic images obtained within the first hour of imaging may be more accurate for demonstrating bleeding localization and a good predictor of requirement of surgical exploration.


Assuntos
Hemorragia Gastrointestinal/diagnóstico por imagem , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Angiografia , Criança , Pré-Escolar , Colonoscopia , Eritrócitos/diagnóstico por imagem , Feminino , Hemorragia Gastrointestinal/patologia , Gastroscopia , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Cintilografia , Estudos Retrospectivos , Adulto Jovem
9.
Ulus Travma Acil Cerrahi Derg ; 28(12): 1744-1746, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36453781

RESUMO

Appendix epiploica without a colon in the hernia sac is a rare condition, which is even rarer if it has hypertrophy and presents as an irreducible hernia. We describe a case of appendix epiploica in a 37-year-old male patient with a strangulated right inguinal hernia that was herniated to the right inguinal canal. Considering the superiority of laparoscopy to open technique for viewing the hernia contents, we planned laparoscopic transabdominal preperitoneal surgery. In the exploration, an indirect hernia was observed in the right groin. Inside was the strangulated appendages epiploica, which extended from the sigmoid colon wall. Anterior wall inguinal hernioplasty was performed. In conclusion, it should not be ignored that there may be appendix epiploica within the hernia sac in inguinal hernias and laparoscopic approaches should be the treatment method of choice.


Assuntos
Hérnia Inguinal , Laparoscopia , Masculino , Humanos , Adulto , Hérnia Inguinal/cirurgia , Colo
10.
Ulus Travma Acil Cerrahi Derg ; 28(4): 537-540, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35485507

RESUMO

Actinomycosis is a rare, chronic granulomatous disease that is challenging to diagnose because the clinical symptoms and signs are nonspecific. Usage of intrauterine device (IUD) or being immunocompromised is facilitating factors. Clinical and radiological findings can mimic malignant neoplasm, inflammatory bowel disorder, or acute diverticulitis. We report a case of actinomyces infection of the colon secondary to IUD, which is a rare cause of acute abdominal pain and can mimic a malignant neoplasm. We also provide a review of the literature. Unnecessary surgery can be avoided with the correct diagnosis of granulomatous infectious diseases that can be treated with antibiotics.


Assuntos
Abdome Agudo , Actinomicose , Dispositivos Intrauterinos , Neoplasias , Dor Abdominal/etiologia , Actinomicose/diagnóstico , Actinomicose/tratamento farmacológico , Actinomicose/etiologia , Colo/patologia , Feminino , Humanos , Dispositivos Intrauterinos/efeitos adversos , Neoplasias/complicações
11.
Ulus Travma Acil Cerrahi Derg ; 17(3): 273-6, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-21935809

RESUMO

Because the extremities are dependent on a single vascular supply, namely the brachial and femoral arteries, injuries around the girdles are challenging, and may contribute to high morbidity rates such as extremity loss, or even mortality due to bleeding, sepsis or vascular compromise. The reconstruction or aided closure of these regions may present additional technical difficulties in the presence of a vascular injury that complicates the use of a microvascular-free transfer, which sometimes may be needed to cover the exposed vessels, bones, tendons, and cartilages whenever the neighboring skin and subcutaneous tissue are inadequate or demised. In these circumstances, pedicled regional flaps of muscular or musculocutaneous consistency (especially if a bulk or rich vascular tissue is needed) would be an alternative. In this report, we present two cases that underwent femoral artery repair via saphenous vein grafting in the vascular surgery clinic followed by our inferiorly based pedicled rectus abdominis muscle flap coverage procedure.


Assuntos
Artérias Epigástricas/cirurgia , Procedimentos de Cirurgia Plástica/métodos , Reto do Abdome/lesões , Reto do Abdome/cirurgia , Retalhos Cirúrgicos , Adulto , Virilha/lesões , Virilha/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Reto do Abdome/irrigação sanguínea
12.
Mediators Inflamm ; 2010: 482950, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20396411

RESUMO

Proinflammatory cytokines, such as tumour necrosis factor alpha (TNFalpha), play fundamental roles in the pathogenesis of acute pancreatitis (AP). The aim of this study was to determine if polymorphisms in the TNFalpha gene are associated with AP. Two polymorphisms located in the promoter region (positions -308 and -238) in TNFalpha gene were determined using polymerase chain reaction- (PCR-) restriction fragment length polymorphism (RFLP) methods in 103 patients with AP and 92 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using logistic regression analysis adjusted for age, sex, BMI and smoking. The frequencies of TNFalpha polymorphisms were both similar in patients with mild or severe pancreatitis, so were in pancreatitis patients and in controls. We suggest that both SNPs of TNFalpha are not genetic risk factor for AP susceptibility (OR = 1.63; 95% CI: 1.13-4.01 for TNFalpha(-308) and OR = 0.86; 95% CI: 0.75-1.77 for TNFalpha(-238)).


Assuntos
Pancreatite/genética , Polimorfismo Genético , Fator de Necrose Tumoral alfa/genética , Doença Aguda , Adulto , Idoso , Feminino , Predisposição Genética para Doença , Humanos , Masculino , Pessoa de Meia-Idade , Pancreatite/imunologia
13.
Ulus Travma Acil Cerrahi Derg ; 16(2): 130-4, 2010 Mar.
Artigo em Turco | MEDLINE | ID: mdl-20517766

RESUMO

BACKGROUND: We aimed to evaluate the efficacy and safety of low molecular weight heparin (LMWH) compared to elastic stockings in combination with intermittent pneumatic compression (ES+IPC) in venous thromboembolism (VTE) prophylaxis in the intensive care unit (ICU) of trauma and emergency surgery. METHODS: From June 2005 to June 2007, 259 patients who were on mechanic ventilation in the ICU were assigned to two groups as either LMWH (152 patients) or ES+IPC (94 patients). Color flow Doppler sonography was performed on the 3rd and 7th days. RESULTS: Deep venous thrombosis was determined in 3 (2%) of the LMWH group and in 1 (1%) in the ES+IPC group. Minor bleeding was seen in 15 patients. The frequency of VTE was 1.5%. Two patients suffered from fatal pulmonary embolism (PE) among a total of 4 patients with PE. CONCLUSION: We believe that the protocol applied for VTE prophylaxis in the Emergency Surgery Department of Istanbul Medical Faculty is effective and safe in this group with such high mortality and morbidity.


Assuntos
Heparina de Baixo Peso Molecular/uso terapêutico , Unidades de Terapia Intensiva , Meias de Compressão/estatística & dados numéricos , Tromboembolia Venosa/prevenção & controle , Ferimentos e Lesões/complicações , Adulto , Idoso , Anticoagulantes/uso terapêutico , Serviço Hospitalar de Emergência , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Segurança , Taxa de Sobrevida , Tromboembolia Venosa/mortalidade , Ferimentos e Lesões/mortalidade
14.
Ulus Travma Acil Cerrahi Derg ; 16(3): 233-6, 2010 May.
Artigo em Inglês | MEDLINE | ID: mdl-20517749

RESUMO

BACKGROUND: Traumatic acute subdural hematoma is the most lethal of all head injuries. METHODS: In this study, 113 patients with the diagnosis of posttraumatic acute subdural hematoma, who were operated between 1998 and 2006, were reviewed retrospectively. Statistical analysis was performed to detect any effects of the variables of age, Glasgow Coma Scale (GCS) score on admission, time interval between the trauma and operation, and abnormality in the pupil reaction on the disease mortality and morbidity. RESULTS: Results obtained in the study are discussed and compared with the related current literature. The overall mortality in 113 patients was 56.6%. CONCLUSION: According to the results, the most important determinants of the prognosis are GCS score of the patient on admission, abnormality in pupil reaction, timing of the operation, and the patient's age.


Assuntos
Hematoma Subdural/cirurgia , Acidentes por Quedas , Acidentes de Trânsito , Doença Aguda , Adulto , Feminino , Escala de Coma de Glasgow , Hematoma Subdural/etiologia , Hematoma Subdural/mortalidade , Humanos , Masculino , Prognóstico , Distúrbios Pupilares/diagnóstico , Estudos Retrospectivos , Resultado do Tratamento , Violência , Ferimentos por Arma de Fogo
15.
Ulus Travma Acil Cerrahi Derg ; 15(5): 448-52, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19779984

RESUMO

BACKGROUND: Angiography is the "gold standard" diagnostic tool for patients presenting soft signs of arterial injury. To reduce the number of unnecessary angiographies, we aimed to evaluate the role of the ankle brachial pressure index (ABPI) in the diagnosis of peripheral arterial injury in extremity trauma with soft signs. METHODS: The data of 1772 patients with the suspicion of peripheral arterial injury was recorded prospectively. Two hundred eighty-three patients (16%) with any hard sign underwent immediate surgery. ABPI was calculated in 1489 patients with soft signs. Patients with ABPI <1 were evaluated by duplex ultrasonography and/or angiography, and if arterial injury was detected, the patients underwent surgery. Patients with an ABPI > or =1 were followed up conservatively. RESULTS: 1343 (90%) patients had ABPI > or =1; seven (0.5%) of them developed symptoms and signs of arterial injury and healed without morbidity. One hundred forty-six (10%) patients had ABPI <1; with DUS/angiography, arterial injury was detected in 39 of them (26.7%), and they underwent surgery. The sensitivity of ABPI <1 was 84.8%; specificity 92.6%; positive predictive value 26.7%; negative predictive value 99.5%; and overall accuracy 92.3%. CONCLUSION: ABPI excludes arterial injury in 99.5% of patients with soft signs of arterial injury and avoids unnecessary examinations in 90% of patients. In the management of extremities with soft signs, ABPI measurement should be the first-line diagnostic choice.


Assuntos
Índice Tornozelo-Braço , Artérias/lesões , Extremidades/irrigação sanguínea , Doenças Vasculares Periféricas/diagnóstico , Adulto , Artérias/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Vasculares Periféricas/cirurgia , Valor Preditivo dos Testes , Estudos Prospectivos , Sensibilidade e Especificidade , Índices de Gravidade do Trauma , Ferimentos não Penetrantes , Ferimentos Penetrantes , Adulto Jovem
16.
Diving Hyperb Med ; 49(4): 253-258, 2019 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-31828743

RESUMO

INTRODUCTION: Mesenteric ischaemia results from a lack of adequate blood flow to and oxygenation of the mesentery and intestines. The aim of the present study was to evaluate the effect of hyperbaric oxygen treatment (HBOT) on the healing process in intestinal mucosa of rats undergoing mesenteric ischaemia and reperfusion. METHODS: Thirty-two Wistar-Albino rats were divided into four groups of eight: 1) ischaemia/reperfusion (I/R); 2) sham operation; 3) I/R+HBOT started 6 hours after reperfusion; 4) I/R+HBOT started 12 hours after reperfusion. In the I/R groups, a vascular clamp was placed across the superior mesenteric artery to occlude arterial circulation for 60 minutes, followed by reperfusion. A dose of HBOT consisted of 100% oxygen breathing for 90 minutes at 2.5 atmospheres absolute pressure. Thirteen doses of HBOT were administered after ischaemia. The rats were sacrificed on the eighth day, and their intestinal tissues were harvested for histopathologic analysis. The tissue levels of catalase, malondialdehyde, and glutathione were determined. RESULTS: The histopathological scores (HSCORE) were consistent with macroscopic examinations. The scores were significantly higher (worse) in Group 1 compared to Group 2, Group 3, and Group 4 (for all comparisons, P < 0.05). Group 4's HSCORE was significantly higher than those of Group 2 and Group 3 (for both comparisons P < 0.05). Group 3's HSCOREs were only marginally higher than Group 2. Group 3 exhibited higher glutathione levels than Group 1 (P < 0.05). There were no significant differences across the groups with respect to malondialdehyde and catalase levels. CONCLUSION: A beneficial effect of HBOT was observed on oxidative stress and inflammation in acute mesenteric ischaemia-reperfusion.


Assuntos
Oxigenoterapia Hiperbárica , Isquemia Mesentérica , Traumatismo por Reperfusão , Animais , Oxigenoterapia Hiperbárica/métodos , Mucosa Intestinal/patologia , Isquemia Mesentérica/prevenção & controle , Oxigênio , Distribuição Aleatória , Ratos , Ratos Wistar , Traumatismo por Reperfusão/prevenção & controle
17.
Langenbecks Arch Surg ; 393(3): 367-72, 2008 May.
Artigo em Inglês | MEDLINE | ID: mdl-17674029

RESUMO

OBJECTIVE: Although there are various experimental pancreatic models in animals, only a few studies have evaluated how intraductal pressure and contrast agent affect the development of pancreatitis after endoscopic retrograde cholangiopancreatograpy (ERCP). MATERIALS AND METHODS: The rats were randomly divided into seven groups (n = 8/group). The rats in all groups underwent laparotomy and their biliopancreatic ducts were cannulated transduodenally using a 24G catheter. In the control group, group 1, the biliopancreatic ducts of the rats were not infused with any fluid. The biliopancreatic ducts of the rats in groups 2, 3, and 4 were infused with 0.5 ml isotonic NaCl solution at 10, 2, and 50 mmHg, respectively. Groups 5, 6, and 7 were given 0.5 ml of 50% diluted contrast agent at 10, 25, and 50 mmHg, respectively. The serum amylase, aspartate aminotransferase (AST), lactic dehydrogenase (LDH), and C-reactive protein (CRP) were measured 24 h after the procedure. Pancreatic tissue was also evaluated histopathologically. RESULTS: Pancreatitis due to the contrast agent was noted when comparing the low pressure isotonic NaCl group and the low pressure contrast group (p < 0.05). Based on serum amylase and CRP values, there was a positive correlation between the severity and frequency of acute pancreatitis and pressure (p < 0.01). AST and LDH levels increased in all of the groups that underwent the procedure; however, no correlation was detected with increasing pressure or with the use of contrast agent (p > 0.05). Both pancreatic edema and the inflammatory cell infiltration score were elevated in isotonic NaCl and contrast group (p < 0.05); however, necrosis was not significantly changed (p > 0.05). CONCLUSION: The results of this study suggest that the main mechanism for preventing pancreatitis after ERCP is to minimize trauma to the pancreatic canal, to cannulate the pancreas only when it is necessary, and to give contrast agent under low pressure when it is needed.


Assuntos
Colangiopancreatografia Retrógrada Endoscópica/efeitos adversos , Meios de Contraste/toxicidade , Iohexol/análogos & derivados , Ductos Pancreáticos/efeitos dos fármacos , Pancreatite Necrosante Aguda/induzido quimicamente , Amilases/sangue , Animais , Aspartato Aminotransferases/sangue , Proteína C-Reativa/metabolismo , Feminino , Pressão Hidrostática , Iohexol/toxicidade , L-Lactato Desidrogenase/sangue , Pâncreas/efeitos dos fármacos , Pâncreas/patologia , Pancreatite Necrosante Aguda/enzimologia , Pancreatite Necrosante Aguda/patologia , Ratos , Ratos Sprague-Dawley , Cloreto de Sódio/farmacologia
18.
J Trauma ; 64(4): 943-8, 2008 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18404060

RESUMO

BACKGROUND: A number of large series' have attempted to examine the management of blunt solid organ injuries; however, only a few studies regarding multiple injuries exist. The aim of this study is to analyze whether multiple solid organ injury affects nonoperative management (NOM) and to look for predictive factors of NOM. METHODS: All patients admitted with a diagnosis of blunt solid organ injury between January 1, 1999 and January 1, 2005 were included in this prospective observational study. Of the 468 patients who had solid organ injury, 46 patients met the inclusion criteria of multiple solid organ injuries. Presentation, mechanism of injury, injury grade, Abbreviated Injury Scale score, management, and outcomes were analyzed. Independent predictive factors of NOM failure were identified. Patients managed nonoperatively were compared with patients who had had emergent laparotomy and patients for whom NOM failed. RESULTS: Fifteen patients (33%) underwent emergency laparotomy because of hypovolemic shock that was unresponsive to aggressive resuscitation, and 31 (66%) were selected for NOM. Among the 31 patients, NOM was successful in 23 (75%). No specific organ injury combination was found to affect NOM failure. Admission lactate level [odds ratio(OR), 1.44; 95% confidence interval (CI), 1.05-1.98; p = 0.025], a drop in the hematocrit greater than 20% in the first hour after admission (OR, 1.13; 95% confidence interval CI, 1.04-1.24; p = 0.007), and solid viscus score (OR, 1.67; 95% CI, 1.03-2.80; p = 0.04) were significant independent risk factors in those patients for whom NOM failed. In logistic regression analysis, hypotension at admission (OR, 0.96; 95% CI, 0.92-0.99; p = 0.014) and transfusion in the first 6 hours after admission (OR, 1.03; 95% CI, 1.00-1.05; p = 0.015) were found to significantly affect the success rate of nonoperative management. CONCLUSION: Lactate levels at admission, solid viscus score, necessity of transfusion, crystalloid resuscitation, and a drop in the hematocrit in the first hour after admission are useful parameters for judging the failure of NOM. Although there is a higher failure rate of NOM in multiple solid organ injury, NOM can still be considered in these cases with extra caution.


Assuntos
Traumatismos Abdominais/terapia , Traumatismo Múltiplo/terapia , Ferimentos não Penetrantes/terapia , Traumatismos Abdominais/mortalidade , Traumatismos Abdominais/cirurgia , Adolescente , Adulto , Idoso , Transfusão de Sangue , Estudos de Coortes , Intervalos de Confiança , Quimioterapia Combinada , Feminino , Seguimentos , Humanos , Escala de Gravidade do Ferimento , Rim/lesões , Fígado/lesões , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Traumatismo Múltiplo/mortalidade , Traumatismo Múltiplo/cirurgia , Razão de Chances , Probabilidade , Estudos Prospectivos , Medição de Risco , Baço/lesões , Análise de Sobrevida , Resultado do Tratamento , Turquia , Ferimentos não Penetrantes/mortalidade , Ferimentos não Penetrantes/cirurgia
19.
Sisli Etfal Hastan Tip Bul ; 52(3): 164-168, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-32595392

RESUMO

OBJECTIVES: Our aim was to study whether laparoscopic appendectomy radix ligation techniques were eutrophic in the development of intra-abdominal abscess. METHODS: Between September 2009 and April 2017, all emergency cases admitted to our surgery polyclinic were reviewed, and the results of the patients who underwent laparoscopic appendectomy were collected. Appendectomy radix ligation techniques were reviewed from surgical notes on discharge reports. Postoperative controls were also reviewed, and any cases with abscess formation were reported. RESULTS: A total of 350 patients were included in the study. Of these cases, 207 were males, and 143 were females. The mean age of the patients was 26.89±4.9 years. One hundred eighty-nine cases were found to have two endoloops placed on top of each other, whereas 161 cases had a 2 mm distance left in between the two endoloops and tied. None of the 189 cases who had endoloops placed on top of each other developed abscess formation. However, of the 161 cases who had endoloops with a 2 mm distance in between, 8 reported with abscess formation in the inner abdomen. Of these eight cases, seven had percutaneous abscess drainage by an interventional radiologist, whereas one was treated with relaparoscopy. CONCLUSION: In the present study, patients who had endoloops placed on top of each other developed no abscess formation, whereas in the literature's gold standard procedure, those with a 2 mm distance left between two endoloops developed an inner abdominal abscess formation in 8 (4.9%) of the patients. We believe that this 2 mm dead space distance left between the two endoloops contributes to the formation of the abscess.

20.
Ulus Travma Acil Cerrahi Derg ; 24(2): 136-144, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29569685

RESUMO

BACKGROUND: Hospital emergency departments (EDs) are confronted with managing dental emergencies of both traumatic and non-traumatic origin. However, the literature suggests inadequate knowledge of the management of traumatic dental injuries (TDIs) among medical professionals. The aim of this study was to investigate the knowledge and attitudes regarding management of TDIs among Istanbul ED physicians. METHODS: Surveys were distributed to emergency departments (ED) directors and their physicians. The survey contained questions about their characteristics and tested their knowledge of managing dental trauma. RESULTS: A total of 126 surveys (13 ED directors and 113 physicians) were returned and included in the analysis. ED physician's knowledge of the appropriate management of crown fractures and avulsion was generally good (p=0.221), but poor for luxation injuries (p=0.0001). Physicians were more likely to have a better knowledge about permanent teeth than about primary teeth (p=0.027). CONCLUSION: Education, monitoring, improved availability of resources, and disciplinary measures in cases of poor compliance are necessary to improve TDI management in hospitals, especially among physicians.


Assuntos
Competência Clínica/estatística & dados numéricos , Serviço Hospitalar de Emergência/estatística & dados numéricos , Médicos , Fraturas dos Dentes/terapia , Estudos Transversais , Humanos , Médicos/normas , Médicos/estatística & dados numéricos , Inquéritos e Questionários , Turquia/epidemiologia
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