Detalhe da pesquisa
1.
Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.
J Med Chem
; 63(23): 15050-15071, 2020 12 10.
Artigo
Inglês
| MEDLINE | ID: mdl-33261314
2.
Assessing compound binding to the Eg5 motor domain using a thermal shift assay.
Anal Biochem
; 392(1): 59-69, 2009 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19497292
3.
Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors.
Bioorg Med Chem Lett
; 19(15): 4034-41, 2009 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19541481
4.
Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577.
Bioorg Med Chem Lett
; 19(24): 6882-9, 2009 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19896847
5.
Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation.
Protein Sci
; 17(2): 240-50, 2008 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18227430
6.
Structural and functional characterization of CFE88: evidence that a conserved and essential bacterial protein is a methyltransferase.
Protein Sci
; 14(6): 1472-84, 2005 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-15929997
7.
Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays.
J Biomol Screen
; 9(6): 533-40, 2004 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-15452340
8.
Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.
J Med Chem
; 54(19): 6548-62, 2011 Oct 13.
Artigo
Inglês
| MEDLINE | ID: mdl-21882820
9.
Design, structure-activity relationships, X-ray crystal structure, and energetic contributions of a critical P1 pharmacophore: 3-chloroindole-7-yl-based factor Xa inhibitors.
J Med Chem
; 51(23): 7541-51, 2008 Dec 11.
Artigo
Inglês
| MEDLINE | ID: mdl-18998662
10.
Molecular basis for increased susceptibility of isolates with atazanavir resistance-conferring substitution I50L to other protease inhibitors.
Antimicrob Agents Chemother
; 49(9): 3825-32, 2005 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-16127059
11.
Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology.
J Biol Chem
; 280(12): 11704-12, 2005 Mar 25.
Artigo
Inglês
| MEDLINE | ID: mdl-15634672
12.
Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme.
Arch Biochem Biophys
; 410(2): 307-16, 2003 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-12573291