Detalhe da pesquisa
1.
Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation.
Hum Mol Genet
; 30(17): 1632-1648, 2021 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34077515
2.
Inhibition of Non-ATG Translational Events in Cells via Covalent Small Molecules Targeting RNA.
J Am Chem Soc
; 137(16): 5336-45, 2015 Apr 29.
Artigo
Inglês
| MEDLINE | ID: mdl-25825793
3.
Hybrids of amino acids and acetylenic DNA-photocleavers: optimising efficiency and selectivity for cancer phototherapy.
Org Biomol Chem
; 10(20): 3974-87, 2012 May 28.
Artigo
Inglês
| MEDLINE | ID: mdl-22495230
4.
Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates.
Beilstein J Org Chem
; 7: 813-23, 2011.
Artigo
Inglês
| MEDLINE | ID: mdl-21804877
5.
C-lysine conjugates: pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy.
J Am Chem Soc
; 131(32): 11458-70, 2009 Aug 19.
Artigo
Inglês
| MEDLINE | ID: mdl-19637922
6.
The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules.
Cell Chem Biol
; 26(2): 179-190.e12, 2019 02 21.
Artigo
Inglês
| MEDLINE | ID: mdl-30503283
7.
Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10.
Nat Commun
; 7: 11647, 2016 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27248057
8.
Small Molecule Recognition and Tools to Study Modulation of r(CGG)(exp) in Fragile X-Associated Tremor Ataxia Syndrome.
ACS Chem Biol
; 11(9): 2456-65, 2016 09 16.
Artigo
Inglês
| MEDLINE | ID: mdl-27276216
9.
Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling.
ACS Chem Biol
; 10(10): 2267-76, 2015 Oct 16.
Artigo
Inglês
| MEDLINE | ID: mdl-26181590
10.
Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome.
Science
; 343(6174): 1002-5, 2014 Feb 28.
Artigo
Inglês
| MEDLINE | ID: mdl-24578575
11.
Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS.
Neuron
; 83(5): 1043-50, 2014 Sep 03.
Artigo
Inglês
| MEDLINE | ID: mdl-25132468
12.
A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome.
ACS Chem Biol
; 7(10): 1711-8, 2012 Oct 19.
Artigo
Inglês
| MEDLINE | ID: mdl-22948243
13.
Engineering pH-gated transitions for selective and efficient double-strand DNA photocleavage in hypoxic tumors.
J Med Chem
; 54(24): 8501-16, 2011 Dec 22.
Artigo
Inglês
| MEDLINE | ID: mdl-22050291
14.
Intracellular DNA damage by lysine-acetylene conjugates.
J Nucleic Acids
; 20102010 Aug 09.
Artigo
Inglês
| MEDLINE | ID: mdl-20814583
15.
Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS.
Neuron
; 84(1): 239, 2014 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28898625