Self-paced regularized adaptive multi-view unsupervised feature selection.

Multi-view unsupervised feature selection (MUFS) is an efficient approach for dimensional reduction of heterogeneous data. However, existing MUFS approaches mostly assign the samples the same weight, thus the diversity of samples is not utilized efficiently. Additionally, due to the presence of various regularizations, the resulting MUFS problems are often non-convex, making it difficult to find the optimal solutions. To address this issue, a novel MUFS method named Self-paced Regularized Adaptive Multi-view Unsupervised Feature Selection (SPAMUFS) is proposed. Specifically, the proposed approach firstly trains the MUFS model with simple samples, and gradually learns complex samples by using self-paced regularizer. l2,p-norm (0

MSIsensor-RNA: Microsatellite Instability Detection for Bulk and Single-cell Gene Expression Data.

Microsatellite instability (MSI) is an indispensable biomarker in cancer immunotherapy. Currently, MSI scoring methods by high-throughput omics methods have gained popularity and demonstrated better performance than the gold standard method for MSI detection. However, the MSI detection method on expression data, especially single-cell expression data, is still lacking, limiting the scope of clinical application and prohibiting the investigation of MSI at a single-cell level. Herein, we developed MSIsensor-RNA, an accurate, robust, adaptable, and standalone software to detect MSI status based on expression values of MSI-associated genes. We demonstrated the favorable performance and promise of MSIsensor-RNA in both bulk and single-cell gene expression data in multiplatform technologies including RNA sequencing (RNA-seq), microarray, and single-cell RNA-seq. MSIsensor-RNA is a versatile, efficient, and robust method for MSI status detection from both bulk and single-cell gene expression data in clinical studies and applications. MSIsensor-RNA is available at https://github.com/xjtu-omics/msisensor-rna.