Detalhe da pesquisa
1.
Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.
Proc Natl Acad Sci U S A
; 120(25): e2218896120, 2023 Jun 20.
Artigo
Inglês
| MEDLINE | ID: mdl-37327313
2.
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Proc Natl Acad Sci U S A
; 117(49): 31365-31375, 2020 12 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33229545
3.
The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology.
Chem Res Toxicol
; 34(2): 189-216, 2021 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33140634
4.
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
Bioorg Med Chem
; 46: 116349, 2021 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34500187
5.
SCAM Detective: Accurate Predictor of Small, Colloidally Aggregating Molecules.
J Chem Inf Model
; 60(8): 4056-4063, 2020 08 24.
Artigo
Inglês
| MEDLINE | ID: mdl-32678597
6.
Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
FASEB J
; 32(3): 1677-1691, 2018 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29146736
7.
Novel Consensus Architecture To Improve Performance of Large-Scale Multitask Deep Learning QSAR Models.
J Chem Inf Model
; 59(11): 4613-4624, 2019 11 25.
Artigo
Inglês
| MEDLINE | ID: mdl-31584270
8.
Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
Proc Natl Acad Sci U S A
; 113(27): 7503-8, 2016 07 05.
Artigo
Inglês
| MEDLINE | ID: mdl-27325754
9.
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Nat Chem Biol
; 12(6): 452-8, 2016 06.
Artigo
Inglês
| MEDLINE | ID: mdl-27110680
10.
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
Bioorg Med Chem
; 26(8): 1727-1739, 2018 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29555419
11.
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.
Proc Natl Acad Sci U S A
; 111(6): 2349-54, 2014 Feb 11.
Artigo
Inglês
| MEDLINE | ID: mdl-24469833
12.
Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase.
Biochemistry
; 55(23): 3329-40, 2016 06 14.
Artigo
Inglês
| MEDLINE | ID: mdl-27226387
13.
Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
Bioorg Med Chem Lett
; 24(2): 630-5, 2014 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24360556
14.
A fluorescence-based high throughput assay for the determination of small molecule-human serum albumin protein binding.
Anal Bioanal Chem
; 406(7): 1867-75, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24390461
15.
RALDH1 Inhibition Shows Immunotherapeutic Efficacy in Hepatocellular Carcinoma.
Cancer Immunol Res
; 12(2): 180-194, 2024 02 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38051215
16.
Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor.
Biochemistry
; 52(24): 4193-203, 2013 Jun 18.
Artigo
Inglês
| MEDLINE | ID: mdl-23713684
17.
Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Nat Chem Biol
; 12(8): 656, 2016 07 19.
Artigo
Inglês
| MEDLINE | ID: mdl-27434767
18.
Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.
ACS Pharmacol Transl Sci
; 6(5): 683-701, 2023 May 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37200814
19.
Lies and Liabilities: Computational Assessment of High-Throughput Screening Hits to Identify Artifact Compounds.
J Med Chem
; 66(18): 12828-12839, 2023 09 28.
Artigo
Inglês
| MEDLINE | ID: mdl-37677128
20.
Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner.
J Med Chem
; 65(18): 12334-12345, 2022 09 22.
Artigo
Inglês
| MEDLINE | ID: mdl-36074125