Hierarchical Attention Neural Network for Event Types to Improve Event Detection.

Event detection is an important task in the field of natural language processing, which aims to detect trigger words in a sentence and classify them into specific event types. Event detection tasks suffer from data sparsity and event instances imbalance problems in small-scale datasets. For this reason, the correlation information of event types can be used to alleviate the above problems. In this paper, we design a Hierarchical Attention Neural Network for Event Types (HANN-ET). Specifically, we select Long Short-Term Memory (LSTM) as the semantic encoder and utilize dynamic multi-pooling and the Graph Attention Network (GAT) to enrich the sentence feature. Meanwhile, we build several upper-level event type modules and employ a weighted attention aggregation mechanism to integrate these modules to obtain the correlation event type information. Each upper-level module is completed by a Neural Module Network (NMNs), event types within the same upper-level module can share information, and an attention aggregation mechanism can provide effective bias scores for the trigger word classifier. We conduct extensive experiments on the ACE2005 and the MAVEN datasets, and the results show that our approach outperforms previous state-of-the-art methods and achieves the competitive F1 scores of 78.9% on the ACE2005 dataset and 68.8% on the MAVEN dataset.

A Bioinspired, Highly Transparent Surface with Dry-Style Antifogging, Antifrosting, Antifouling, and Moisture Self-Cleaning Properties.

Transparent coatings with antireflection, antifogging, antifrosting, antifouling, and moisture self-cleaning properties can dramatically improve the efficiency and convenience of optical elements and thus are highly desirable for practical applications. Here, it is demonstrated that a bionic nanocone surface (BNS) fabricated by a facile, low-cost process consisting of template-assisted prepolymer curing followed by surface modification can possess the multiple functions listed above. The polymer coating firmly adheres to a glass substrate due to bonding agents. After SiO2 nanoparticle deposition and low-surface-energy fluorosilane modification, the coating shows low microdroplet adhesion. As a result, the as-prepared BNS exhibits a high transmittance when exposed to fog and good clarity even when the temperature decreases to -20 °C in a humid environment. Dipping the BNS into exemplified graphite powder has almost no influence on the transparency, and the BNS can realize self-cleaning of moisture when the surface is covered with a thick layer of man-made contaminants.

[Changes of CD4 + CD25 + Foxp3 + regulatory T cells in the peripheral blood and their correlation with insulin resistance in different stages of prostate cancer].

OBJECTIVE: To investigate the changes of CD4 + CD25 + Foxp3 + regulatory T cells in the peripheral blood mononuclear cells (PBMC) and their association with insulin resistance in different stages of prostate cancer (PCa). METHODS: Using flow cytometry, we counted the CD4+ CD25 + Foxp3 + regulatory T cells in the PBMCs of 62 PCa patients (5 cases of TNM stage I, 16 cases of stage II, 21 cases of stage III, and 20 cases of stage IV) and 42 normal healthy controls, and calculated their proportion in the CD4+ T-lymphocytes. We determined the levels of fast blood glucose (FBG) and fast insulin (FINS) for the insulin resistance index (HOMA-IR), obtained the serum IGF-1 level by ELISA, and analyzed the relationship of the count and proportion of CD4+ CD25+ Foxp3+ regulatory T cells with insulin resistance by comparison between the PCa patients and normal healthy controls. RESULTS: Compared with the control group, the PCa patients showed significantly increased HOMA-IR (3.68 ± 1.42 vs 6.68 ± 1.66), decreased level of serum IGF-1 ([164.56 ± 30.58] vs [96.39 ± 21.21] ng/ml), and elevated count ([1.99 ± 0.78 ] x 10(7) vs [3.55 ± 0.29] x 10(7)) and proportion ([5.33 ± 0.65] vs [13.88 ± 0.96]%) of CD4 + CD25 + Foxp3 regulatory T cells in the PBMCs. The TNM stage was correlated positively with the count and percentage of CD4 + CD25+ Foxp3 + regulatory T cells and HOMA-IR, but negatively with the level of serum IGF-1. Meanwhile, the count and percentage of CD4 + CD25 + Foxp3 + regulatory T cells were found to have a positive correlation with HOMA-IR (r = 0.722 and 0.689, P < 0.01) but a negative correlation with the level of serum IGF-1 (r = -0.747 and -0.896, P < 0.01). CONCLUSION: The count and proportion of CD4+ CD25 + Foxp3 + regulatory T cells in the peripheral blood and insulin resistance increase with the elevated stage of PCa. CD4 + CD25 + Foxp3 + regulatory T cells may be involved in the occurrence and progression of PCa by regulating insulin resistance.

Calixarene-Functionalized Porous Carbon Aerogels for Polysulfide Capture: Cathodes for High Performance Lithium-Sulfur Batteries.

A cage-type composite was successfully prepared by attaching p-sulfonatocalix[4]arene to a porous activated carbon aerogel (ACA). The resulting composite showed a high specific surface area of 1620.7 m2 g-1 and a high sulfur loading of 2.5 mg cm-2 . The calixarene is uniformly dispersed on the carbon spheres and efficiently captures polysulfides by interaction with the sulfonate groups. Meanwhile, the cross-linked porous structure of the composite restricts the migration of polysulfides. The cathode delivers an outstanding electrochemical performance with an initial capacity of 1304.7 mAh g-1 at 0.2 C. Furthermore, it displays excellent long-term cycling stability, maintaining 884.7 mAh g-1 after 300 cycles at 0.5 C. Density functional theory (DFT) adsorption calculations support the strong interaction between the calixarenes and polysulfides and reveal the capture mechanism.

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration.

Tissue repair and regenerative medicine address the important medical needs to replace damaged tissue with functional tissue. Most regenerative medicine strategies have focused on delivering biomaterials and cells, yet there is the untapped potential for drug-induced regeneration with good specificity and safety profiles. The Hippo pathway is a key regulator of organ size and regeneration by inhibiting cell proliferation and promoting apoptosis. Kinases MST1 and MST2 (MST1/2), the mammalian Hippo orthologs, are central components of this pathway and are, therefore, strong target candidates for pharmacologically induced tissue regeneration. We report the discovery of a reversible and selective MST1/2 inhibitor, 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide (XMU-MP-1), using an enzyme-linked immunosorbent assay-based high-throughput biochemical assay. The cocrystal structure and the structure-activity relationship confirmed that XMU-MP-1 is on-target to MST1/2. XMU-MP-1 blocked MST1/2 kinase activities, thereby activating the downstream effector Yes-associated protein and promoting cell growth. XMU-MP-1 displayed excellent in vivo pharmacokinetics and was able to augment mouse intestinal repair, as well as liver repair and regeneration, in both acute and chronic liver injury mouse models at a dose of 1 to 3 mg/kg via intraperitoneal injection. XMU-MP-1 treatment exhibited substantially greater repopulation rate of human hepatocytes in the Fah-deficient mouse model than in the vehicle-treated control, indicating that XMU-MP-1 treatment might facilitate human liver regeneration. Thus, the pharmacological modulation of MST1/2 kinase activities provides a novel approach to potentiate tissue repair and regeneration, with XMU-MP-1 as the first lead for the development of targeted regenerative therapeutics.