Detalhe da pesquisa
1.
Conversion of cassava leaf to bioavailable, high-protein yeast cell biomass.
J Sci Food Agric
; 99(6): 3034-3044, 2019 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-30488472
2.
Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors.
Bioorg Med Chem Lett
; 23(9): 2522-6, 2013 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23541670
3.
Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome.
Bioorg Med Chem Lett
; 23(9): 2793-800, 2013 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23540648
4.
Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 20(15): 4614-9, 2010 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20584604
5.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides.
Bioorg Med Chem Lett
; 19(19): 5652-6, 2009 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19709881
6.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones.
Bioorg Med Chem Lett
; 19(13): 3642-6, 2009 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19457662
7.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids.
Bioorg Med Chem Lett
; 19(19): 5648-51, 2009 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19700319
8.
Structures of human plasma ß-factor XIIa cocrystallized with potent inhibitors.
Blood Adv
; 2(5): 549-558, 2018 03 13.
Artigo
Inglês
| MEDLINE | ID: mdl-29519898
9.
Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin.
ACS Med Chem Lett
; 8(3): 321-326, 2017 Mar 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28337324
10.
Transport of levovirin prodrugs in the human intestinal Caco-2 cell line.
J Pharm Sci
; 95(6): 1318-25, 2006 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-16634069
11.
Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents.
J Med Chem
; 47(25): 6124-7, 2004 Dec 02.
Artigo
Inglês
| MEDLINE | ID: mdl-15566283
12.
Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors.
J Med Chem
; 57(6): 2683-91, 2014 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-24520947
13.
3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models.
J Med Chem
; 56(1): 345-56, 2013 Jan 10.
Artigo
Inglês
| MEDLINE | ID: mdl-23214979