The influence of perceived discrimination in healthcare settings on psychological distress among a diverse sample of older Asian Americans.

OBJECTIVES: The purpose of this study was to determine the relationship between discrimination in healthcare settings and psychological distress. METHOD: This study utilized a retrospective cross-sectional study design. The dataset was obtained from 2015-2017 California Health Interview Survey (CHIS). Healthcare discrimination experience (yes, no) was measured using the following question "Over your entire lifetime, how often have you been treated unfairly when getting medical care (never, rarely, sometimes, often)?". Psychological distress was the study outcome and was measured using the Kessler Psychological Distress Scale. A composite score (0-24) was created for psychological distress for the prior 30 days and for the worse most in the past 12 months. A hierarchical multivariate linear regression was conducted to examine the influence of healthcare discrimination experience on psychological distress after adjusting for other covariates. RESULTS: Study participants (weighted N = 1,360,487) had a mean age of 64.35 years (SD = 0.61), were primarily female (54.93%), heterosexual (96.61%), and married or living with a partner (73.37%). About 10.00% of older Asian Americans ever perceived healthcare discrimination over their entire lifetime. Perceived discrimination was associated with higher levels of psychological distress for the past 30 days (beta= 2.107, SE = 0.662, p < 0.05) and for the worst month in the past year (beta= 2.099, SE = 0.697, p < 0.05) after controlling for covariates. CONCLUSION: Self-reported discrimination was relatively low in this sample of older Asian American adults. However, consistent with prior research, perceived discrimination in the healthcare setting was associated with increased psychological distress. The findings have implications for improving the quality of health care services received.

A novel biomarker selection method using multimodal neuroimaging data.

Identifying biomarkers is essential to obtain the optimal therapeutic benefit while treating patients with late-life depression (LLD). We compare LLD patients with healthy controls (HC) using resting-state functional magnetic resonance and diffusion tensor imaging data to identify neuroimaging biomarkers that may be potentially associated with the underlying pathophysiology of LLD. We implement a Bayesian multimodal local false discovery rate approach for functional connectivity, borrowing strength from structural connectivity to identify disrupted functional connectivity of LLD compared to HC. In the Bayesian framework, we develop an algorithm to control the overall false discovery rate of our findings. We compare our findings with the literature and show that our approach can better detect some regions never discovered before for LLD patients. The Hub of our discovery related to various neurobehavioral disorders can be used to develop behavioral interventions to treat LLD patients who do not respond to antidepressants.

Development of a Bayesian multimodal model to detect biomarkers in neuroimaging studies.

In this article, we developed a Bayesian multimodal model to detect biomarkers (or neuromarkers) using resting-state functional and structural data while comparing a late-life depression group with a healthy control group. Biomarker detection helps determine a target for treatment intervention to get the optimal therapeutic benefit for treatment-resistant patients. The borrowing strength of the structural connectivity has been quantified for functional activity while detecting the biomarker. In the biomarker searching process, thousands of hypotheses are generated and tested simultaneously using our novel method to control the false discovery rate for small samples. Several existing statistical approaches, frequently used in analyzing neuroimaging data have been investigated and compared via simulation with the proposed approach to show its excellent performance. Results are illustrated with a live data set generated in a late-life depression study. The role of detected biomarkers in terms of cognitive function has been explored.

Socioeconomic status impacts blood pressure response to positive airway pressure treatment.

STUDY OBJECTIVES: Positive airway pressure (PAP) treatment of obstructive sleep apnea reduces blood pressure (BP). Retrospective data suggest that African Americans (AA), a group at high-risk for hypertensive organ dysfunction, may have a greater BP response to PAP therapy than European Americans (EA). We examined the difference in 24-hour BP response to 3 months of PAP treatment between AA and EA. METHODS: Participants (n = 259, 161 AA and 98 EA) with apnea-hypopnea index ≥ 15 events/h from 2 prospective cohorts were included. t-Tests and multiple linear regression were used to examine BP outcomes in AA vs EA, adjusting for PAP adherence, socioeconomic status, and baseline characteristics. RESULTS: Participants were middle aged (mean ± SD, 53.8 ± 9.3 years), 86% (227) men, apnea-hypopnea index 35.6 ± 19.2 events/h, and PAP adherence of 3.36 ± 2.24 h/day. The reductions in 24-hour systolic and diastolic BP (mm Hg) were not different in AA vs EA (systolic = -1.13 ± 12.1 vs -0.61 ± 12.8, P = .80 and diastolic = -0.74 ± 7.9 vs -0.80 ± 7.4, P = .96), and race was not a predictor of 24-hour systolic or diastolic BP reduction (P = .75 and 0.54). Socioeconomic status and PAP adherence demonstrated a significant interaction; low socioeconomic status was associated with an increase in 24-hour systolic BP (ß = 19.3, P = .03) in the absence of PAP use but a greater reduction in 24-hour systolic BP with higher PAP adherence (ß = -3.96, P = .03). CONCLUSIONS: Twenty-four hour BP response to PAP treatment is similar in AA and EA. Adherence to PAP treatment is more effective in improving 24-hour systolic BP in those with low SES. CLINICAL TRIAL REGISTRATION: Registry: ClinicalTrials.gov; Name: Race and CPAP Effectiveness (RACE); URL: https://clinicaltrials.gov/ct2/show/NCT01960465; Identifier: NCT01960465 and Registry: ClinicalTrials.gov; Name: The Effects of Treating Obese and Lean Patients with Sleep Apnea (PISA); URL: https://clinicaltrials.gov/ct2/show/NCT01578031; Identifier: NCT01578031. CITATION: Imayama I, Gupta A, Yen PS, et al. Socioeconomic status impacts blood pressure response to positive airway pressure treatment. J Clin Sleep Med. 2022;18(5):1287-1295.

Intimate partner violence and Its Relationship with Psychological Distress Among Older Asian Americans: Results from the California Health Interview Survey.

OBJECTIVE: This study aimed to examine the influence of intimate partner violence on psychological distress among a diverse sample of older Asian Americans living in California. METHODS: Participants in the 2007-2009 California Health and Interview Survey (CHIS) aged fifty years and older and self-reported as Asian Americans were included in the study. The primary independent variable was the history of any intimate partner violence (physical or sexual violence) since 18 years of age. The Kessler Psychological Distress Six-item Scale was used to measure the study dependent variable. A composite score (0-24) was created for psychological distress during the past 30 days as well as for the one month in the past 12 months when they were at their worst emotionally. Other covariates, including acculturation and demographic factors, were measured. Hierarchical multivariate linear regressions were conducted to examine the influence of intimate partner violence on psychological distress after adjusting for covariates. RESULTS: In the study, about 8% of older Asian Americans reported ever experiencing intimate partner violence. After controlling for level of acculturation and demographic factors, a history of intimate partner violence was significantly associated with higher levels of psychological distress for the past month (beta = 2.07, SE = 0.74, p < 0.05) and for the worst month in the past year (beta = 1.99, SE = 0.68, p < 0.05). CONCLUSION: Intimate partner violence is a significant risk factor for distress among older Asian Americans. Culturally targeted violence prevention efforts and treatment approaches for individuals impacted by violence are needed in this highly underserved segment of older Americans.

Network strength and dewaterability of flocculated activated sludge.

Works in literature proposed the use of the rheological properties of wastewater sludges as an index for conditioner assessment and control. We demonstrated in this work, on the contrary, that one could not justify the consistency of the commonly used rheological characteristics of the sewage sludge samples taken from the same site but at different dates. A physically relevant index was proposed instead for describing the total network strength, which was hypothesized to correlate the dewatering efficiency of flocculated sludge. Based on this index, the network of a sludge was demonstrated to be largely destroyed after shearing, while the relaxation in an unbound environment or mild pouring over action could partially reinstall the structure. Moreover, a uniform shear rate field could produce network of greater strength when compared with that conditioned in a stirred tank.

Butler-Sugimoto monomolecular bilayer interface model: the effect of oxygen on the surface tension of a liquid metal and its wetting of a ceramic.

The influence of oxygen on liquid-gas surface tension of molten metals has been well-investigated experimentally and modeled theoretically via the Szyszkowski equation, derivable from the Butler molecular monolayer interface model. However, there is no corresponding model describing the experimentally observed profound effect of oxygen partial pressure on solid-liquid surface tension as well as on contact angle of molten metals on ceramic substrates. Here, we utilize the Butler-Sugimoto thermodynamic approach based on a monomolecular bilayer interface model to investigate the effect of oxygen partial pressure on liquid-gas as well as solid-liquid surface tension of molten Cu/Al2O3 and molten Ag/Al2O3 systems. It is shown that both liquid-gas and solid-liquid surface tension are a strong function of oxygen activity in the melt, which, in turn, depends on gas-phase oxygen partial pressure, in conformity with experiments. The change in solid-liquid surface tension and wetting is also greatly affected by the change in liquid-gas surface tension. This improved understanding is of practical significance in many applications.