Detalhe da pesquisa
1.
Extracellular chaperones and proteostasis.
Annu Rev Biochem
; 82: 295-322, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23350744
2.
Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.
PLoS Biol
; 22(1): e3002462, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-38289969
3.
ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis.
Hum Mol Genet
; 32(14): 2386-2398, 2023 07 04.
Artigo
Inglês
| MEDLINE | ID: mdl-37220877
4.
TDP-43 is a ubiquitylation substrate of the SCFcyclin F complex.
Neurobiol Dis
; 167: 105673, 2022 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35231559
5.
Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells.
J Cell Sci
; 133(15)2020 08 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32661089
6.
P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons.
Purinergic Signal
; 18(4): 451-467, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35478453
7.
Non-Viral Vector-Mediated Gene Therapy for ALS: Challenges and Future Perspectives.
Mol Pharm
; 18(6): 2142-2160, 2021 06 07.
Artigo
Inglês
| MEDLINE | ID: mdl-34010004
8.
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins.
Glia
; 68(2): 407-421, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31596526
9.
SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS.
J Cell Sci
; 131(11)2018 06 12.
Artigo
Inglês
| MEDLINE | ID: mdl-29748379
10.
Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt Bridge Formation.
Anal Chem
; 92(2): 1702-1711, 2020 01 21.
Artigo
Inglês
| MEDLINE | ID: mdl-31854977
11.
The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice.
Purinergic Signal
; 16(1): 109-122, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32170537
12.
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.
Proc Natl Acad Sci U S A
; 114(20): E3935-E3943, 2017 05 16.
Artigo
Inglês
| MEDLINE | ID: mdl-28396410
13.
Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis.
Biochemistry
; 58(39): 4086-4095, 2019 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31529970
14.
Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.
Cell Mol Life Sci
; 75(2): 335-354, 2018 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28852778
15.
Assessment of metal concentrations in the SOD1G93A mouse model of amyotrophic lateral sclerosis and its potential role in muscular denervation, with particular focus on muscle tissue.
Mol Cell Neurosci
; 88: 319-329, 2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29524628
16.
Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons.
Acta Neuropathol
; 136(3): 445-459, 2018 09.
Artigo
Inglês
| MEDLINE | ID: mdl-29943193
17.
The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis.
Biochim Biophys Acta Mol Basis Dis
; 1863(11): 2762-2771, 2017 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28711596
18.
Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms.
Proc Natl Acad Sci U S A
; 111(9): 3620-5, 2014 Mar 04.
Artigo
Inglês
| MEDLINE | ID: mdl-24550511
19.
Walking the tightrope: proteostasis and neurodegenerative disease.
J Neurochem
; 137(4): 489-505, 2016 05.
Artigo
Inglês
| MEDLINE | ID: mdl-26872075
20.
Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.
Cell Mol Neurobiol
; 36(3): 377-81, 2016 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-26908139