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Objective To observe the value of dynamic contrast enhanced MRI(DCE-MRI)combined with intravoxel incoherent motion(IVIM)for preoperative evaluation on pathological type of rectal cancer.Methods Totally 81 patients with rectal adenocarcinoma were enrolled and divided into mucinous adenocarcinoma group(n=36)or non mucinous adenocarcinoma group(n=45)based on postoperative pathological results.Parameters of DCE-MRI and IVIM,including rate constant(Kep),volume transfer constant(Ktrans),extravascular extracellular volume fraction(Ve),true diffusion coefficient(D),pseudo diffusion coefficient(D*)and perfusion fraction(f)were compared between groups.Logistic regression analysis was performed,the efficacy of the above parameters for evaluation on pathological type of rectal cancer were explored.Results Kep,Ktrans,D*and f of mucinous adenocarcinoma group were all smaller than those of non mucinous adenocarcinoma group(all P＜0.05).Kep and f were both impact factors of pathological type of rectal cancer(both P＜0.05).The area under the curve(AUC)of Kep,f and Kep+f for preoperative evaluation on pathological type of rectal cancer was 0.774,0.880 and 0.906,respectively,with sensitivity of 69.44％,77.78％and 86.11％,specificity of 82.22％,91.11％and 91.11％,respectively.AUC of Kep was lower than that of Kep+f(P＜0.05).Conclusion DCE-MRI combined with IVIM could effectively evaluate the pathological type of rectal cancer preoperation.
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Objective To observe the value of multimodal imaging for diagnosis of cardiac space-occupying lesions.Methods Data of 70 patients with cardiac space-occupying lesions who underwent echocardiography and cardiac CT(CCT)were retrospectively analyzed,among them 35 also underwent cardiac MRI(CMRI).The value of multimodal imaging for diagnosis of cardiac space-occupying lesions were explored according to the results of surgical pathology or clinical diagnosis.Results Among 70 cases,benign tumors were confirmed by surgical pathology in 43 cases,while malignant tumors were confirmed by surgical pathology in 3 cases and clinically diagnosed in 1 case.Meanwhile,non-tumor-occupying lesions were clinically diagnosed in 23 cases,all obviously shrunken after treatments.Among 70 cases,echocardiography correctly diagnosed 57 cases,misdiagnosed 8 cases and unclearly diagnosed 5 cases,with diagnostic accuracy rate of 81.43%(57/70).CCT correctly diagnosed 63 cases,misdiagnosed 4 cases but missed 3 cases,with diagnostic accuracy rate of 90.00%(63/70).CMRI outcomes in all 35 cases were consistent with surgical pathologic results,with diagnostic accuracy rate of 100%(35/35).Conclusion Multimodal imaging might provide objective evidences for diagnosis and treatment of cardiac space-occupying lesions.
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OBJECTIVE@#To investigate the effect and mechanism of glucosides of chaenomeles speciosa (GCS) on ischemia/reperfusion-induced brain injury in mouse model.@*METHODS@#Fifty 8-week C57BL/C mice were randomly divided into five groups with 10 in each group:sham group, model group, GCS 30 mg/kg group, GCS 60 mg/kg group and GCS 90 mg/kg group, and the GCS was administrated by gavage (once a day) for 14 d. HE staining was performed to investigate the cell morphology; the Zea-Longa scores were measured for neurological activity; TUNEL staining was performed to investigate the cell apoptosis; ELISA was used to detected the oxidative stress and inflammation; Western Blot was performed to investigate the key pathway and neurological functional molecules.@*RESULTS@#Compared with the sham group, the brain tissues in model group were seriously damaged, presenting severe cell apoptosis, oxidative stress and inflammation, associated with increased NF-κB P65 and TNF-α levels as well as decreased myelin associate glycoprotein (MAG) and oligodendrocyte-myelin glycoprotein (OMgp)levels (all <0.01). Compared with the model group, the brain tissues in GCS groups were ameliorated, and cell apoptosis, oxidative stress and inflammation were inhibited, associated with decreased NF-κB P65 and TNF-α levels as well as increased MAG and OMgp levels (all <0.01), which were more markedly in GCS 60 mg/kg group.@*CONCLUSIONS@#GCS can inhibit the NF-κB P65 and TNF-α, reduce the oxidative stress and inflammation, decrease the cell apoptosis in mouse ischemia/reperfusion-induced brain injury model, and 60 mg/kg GCS may be the optimal dose.