Adaptive clutter rejection for 3D color Doppler imaging: preliminary clinical study.

In three-dimensional (3D) ultrasound color Doppler imaging (CDI), effective rejection of flash artifacts caused by tissue motion (clutter) is important for improving sensitivity in visualizing blood flow in vessels. Since clutter characteristics can vary significantly during volume acquisition, a clutter rejection technique that can adapt to the underlying clutter conditions is desirable for 3D CDI. We have previously developed an adaptive clutter rejection (ACR) method, in which an optimum filter is dynamically selected from a set of predesigned clutter filters based on the measured clutter characteristics. In this article, we evaluated the ACR method with 3D in vivo data acquired from 37 kidney transplant patients clinically indicated for a duplex ultrasound examination. We compared ACR against a conventional clutter rejection method, down-mixing (DM), using a commonly-used flow signal-to-clutter ratio (SCR) and a new metric called fractional residual clutter area (FRCA). The ACR method was more effective in removing the flash artifacts while providing higher sensitivity in detecting blood flow in the arcuate arteries and veins in the parenchyma of transplanted kidneys. ACR provided 3.4 dB improvement in SCR over the DM method (11.4 +/- 1.6 dB versus 8.0 +/- 2.0 dB, p < 0.001) and had lower average FRCA values compared with the DM method (0.006 +/- 0.003 versus 0.036 +/- 0.022, p < 0.001) for all study subjects. These results indicate that the new ACR method is useful for removing nonstationary tissue motion while improving the image quality for visualizing 3D vascular structure in 3D CDI.

Nonlinear diffusion in Laplacian pyramid domain for ultrasonic speckle reduction.

A new speckle reduction method, i.e., Laplacian pyramid-based nonlinear diffusion (LPND), is proposed for medical ultrasound imaging. With this method, speckle is removed by nonlinear diffusion filtering of bandpass ultrasound images in Laplacian pyramid domain. For nonlinear diffusion in each pyramid layer, a gradient threshold is automatically determined by a variation of median absolute deviation (MAD) estimator. The performance of the proposed LPND method has been compared with that of other speckle reduction methods, including the recently proposed speckle reducing anisotropic diffusion (SRAD) and nonlinear coherent diffusion (NCD). In simulation and phantom studies, an average gain of 1.55 dB and 1.34 dB in contrast-to-noise ratio was obtained compared to SRAD and NCD, respectively. The visual comparison of despeckled in vivo ultrasound images from liver and carotid artery shows that the proposed LPND method could effectively preserve edges and detailed structures while thoroughly suppressing speckle. These preliminary results indicate that the proposed speckle reduction method could improve image quality and the visibility of small structures and fine details in medical ultrasound imaging.

New demodulation method for efficient phase-rotation-based beamforming.

In this paper, we present a new demodulation method to reduce hardware complexity in phase-rotation-based beamforming. Due to its low sensitivity to phase delay errors, quadrature demodulation, which consists of mixing and lowpass filtering, is commonly used in ultrasound machines. However, because it requires two lowpass filters for each channel to remove harmonics after mixing, the direct use of quadrature demodulation is computationally expensive. To alleviate the high computational requirement in quadrature demodulation, we have developed a two-stage demodulation technique in which dynamic receive focusing is performed on the mixed signal instead of the complex baseband signal. Harmonics then are suppressed by using only two lowpass filters. When the number of channels is 32, the proposed two-stage demodulation reduces the necessary number of multiplications and additions for phase-rotation beamforming by 82.7% and 88.2%, respectively, compared to using quadrature demodulation. We have found from simulation and phantom studies that the proposed method does not incur any significant degradation in image quality in terms of axial and lateral resolution. These preliminary results indicate that the proposed two-stage demodulation method could contribute to significantly reducing the hardware complexity in phase-rotation-based beamforming while providing comparable image quality.

New demodulation filter in digital phase rotation beamforming.

In this paper, we present a new quadrature demodulation filter to reduce hardware complexity in digital phase rotation beamforming. Due to its low sensitivity to phase delay errors, digital quadrature demodulation is commonly used in ultrasound machines. However, since it requires two lowpass filters for each channel to remove harmonics, the direct use of conventional finite impulse response (FIR) filters in ultrasound machines is computationally expensive and burdensome. In our new method, an efficient multi-stage uniform coefficient (MSUC) filter is utilized to remove harmonic components in phase rotation beamforming. In comparison with the directly implemented FIR (DI-FIR) and the previously-proposed signed-power-of-two FIR (SPOT-FIR) lowpass filters, the proposed MSUC filter reduces the necessary hardware resources by 93.9% and 83.9%, respectively. In simulation, the MSUC filter shows a negligible degradation in image quality. The proposed method resulted in comparable spatial and contrast resolution to the DI-FIR approach in the phantom study. These preliminary results indicate that the proposed quadrature demodulation filtering method could significantly reduce the hardware complexity in phase rotation beamforming while maintaining comparable image quality.

Adaptive clutter filtering for ultrasound color flow imaging.

In this article, we present an adaptive clutter rejection method for selecting different clutter filters in ultrasound color flow imaging. A single clutter filter is typically used to reject the clutter. Because the clutter characteristics vary in both space and time, the single clutter filter approach has difficulty in providing optimum clutter rejection in ultrasound images. To achieve more accurate velocity estimation, we have developed a method to select a clutter filter adaptively at each location in an image from a set of predefined filters. Selection criteria have been developed based on the underlying clutter characteristics and the properties of various filters (e.g., minimum-phase finite impulse response, projection-initialized infinite impulse response and polynomial regression). We have incorporated our adaptive clutter rejection method in an ultrasound system. We have found that our adaptive method can reduce the mean absolute error between the estimated and true flow velocities significantly compared with the conventional methods, in which a single clutter filter is used throughout the entire image. With in vivo abdominal data, we obtained an average gain of 5.0 dB in signal-to-clutter ratio (SCR), compared with the conventional method. These preliminary results indicate that the proposed adaptive method could improve the accuracy of flow velocity estimation in ultrasound color flow imaging through the improvement in SCR and the reduction in bias.

Evaluation of ultrasound synthetic aperture imaging using bidirectional pixel-based focusing: preliminary phantom and in vivo breast study.

In medical ultrasound imaging, lateral resolution is limited when using a fixed transmit focusing. Various synthetic aperture (SA) techniques, in which two-way dynamic focusing is enabled by utilizing prebeamformed radio-frequency (RF) data have been proposed for improving the spatial resolution. However, SA methods were not extensively evaluated in terms of their clinical performance. In this paper, a phantom and an in vivo evaluation of the SA method with bidirectional pixel-based focusing (BiPBF) is presented in comparison with the conventional beamforming. The performance of the proposed SA-BiPBF was assessed with a blind study and the established breast imaging-reporting and data system (BI-RADS), in addition to measuring contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR). Prebeamformed RF data were acquired from a tissue mimicking phantom (Model 040, CIRS Inc., Norfolk, VA, USA) and from patients with breast lesions by using a commercial ultrasound scanning system with a linear array transducer equipped with a research package and parallel data acquisition system (SonixTouch, SonixDAQ, and L14-5/38, Ultrasonix Corp., Canada). In phantom and in vivo experiments, a default setting of a breast preset was applied (e.g., the center frequency of 10 MHz and acoustic output of MI = 0.66). In phantom experiment, the SA-BiPBF method showed higher CNR and SNR values compared to the conventional method (3.4 and 23.9 dB versus 3.1 and 15.8 dB, respectively). In addition, the lateral resolution and penetration depth were increased by 95.4% and 40.3%, respectively. Consistent with the phantom experiment, in the in vivo experiment with ten patients, the CNR value for the SA method was 3.3 ± 0.5 compared to 2.8 ± 0.8 for the conventional method. Similarly, the SNR values with the SA-BiPBF and conventional methods were 34.0 ± 3.6 and 27.2 ± 3.4 dB, respectively. From the experiments, it was shown in side-by-side comparisons that the image quality of the SA-BiPBF method was considerably improved in both phantom and in vivo breast images. However, the SA-BiPBF image showed different features compared to the conventional one in the in vivo experiments. These features are resulting from the increased image quality of the SA-BiPBF method but are not always perceived as improvements by the radiologists.

New adaptive clutter rejection for ultrasound color Doppler imaging: in vivo study.

Clutter rejection is essential for accurate flow estimation in ultrasound color Doppler imaging. In this article, we present a new adaptive clutter rejection (ACR) technique where an optimum filter is dynamically selected depending upon the underlying clutter characteristics (e.g., tissue acceleration and power). We compared the performance of the ACR method with other adaptive methods, i.e., down-mixing (DM) and adaptive clutter filtering (ACF), using in vivo data acquired from the kidney, liver and common carotid artery. With the kidney data, the ACR method provided an average improvement of 3.05 dB and 1.7 dB in flow signal-to-clutter ratio (SCR) compared with DM and ACF, respectively. With the liver data, SCR was improved by 2.75 dB and 1.8 dB over DM and ACF while no significant improvement with ACR was found in the common carotid artery data. Thus, the proposed adaptive method could provide more accurate flow estimation by improving clutter rejection in abdominal ultrasound color Doppler imaging pending validation.

A fully programmable computing architecture for medical ultrasound machines.

Application-specific ICs have been traditionally used to support the high computational and data rate requirements in medical ultrasound systems, particularly in receive beamforming. Utilizing the previously developed efficient front-end algorithms, in this paper, we present a simple programmable computing architecture, consisting of a field-programmable gate array (FPGA) and a digital signal processor (DSP), to support core ultrasound signal processing. It was found that 97.3% and 51.8% of the FPGA and DSP resources are, respectively, needed to support all the front-end and back-end processing for B-mode imaging with 64 channels and 120 scanlines per frame at 30 frames/s. These results indicate that this programmable architecture can meet the requirements of low- and medium-level ultrasound machines while providing a flexible platform for supporting the development and deployment of new algorithms and emerging clinical applications.

Coded excitation for ultrasound tissue harmonic imaging.

Coded excitation can improve the signal-to-noise ratio (SNR) in ultrasound tissue harmonic imaging (THI). However, it could suffer from the increased sidelobe artifact caused by incomplete pulse compression due to the spectral overlap between the fundamental and harmonic components of ultrasound signal after nonlinear propagation in tissues. In this paper, three coded tissue harmonic imaging (CTHI) techniques based on bandpass filtering, power modulation and pulse inversion (i.e., CTHI-BF, CTHI-PM, and CTHI-PI) were evaluated by measuring the peak range sidelobe level (PRSL) with varying frequency bandwidths. From simulation and in vitro studies, the CTHI-PI outperforms the CTHI-BF and CTHI-PM methods in terms of the PRSL, e.g., -43.5dB vs. -24.8dB and -23.0dB, respectively.

Image quality evaluation with a new phase rotation beamformer.

Over the last few decades, dynamic focusing based on digital receive beamforming (DRBF) has led to significant improvements in image quality. However, it is computationally very demanding due to its requirement for multiple lowpass filters (e.g., a complex filter for each receive channel in quadrature demodulation-based phase rotation beamformers (QD-PRBF)). We recently developed a novel phase rotation beamformer with reduced complexity, which can lower: 1) the number of lowpass filters using 2-stage demodulation (TSD) and 2) the number of beamforming points using adap tive field-of-view (AFOV) imaging. In TSD, dynamic focusing is performed on the mixed signals, while sampling frequency of the beamformed signal (i.e., beamforming frequency) is adjusted based on the displayed field-of-view (FOV) size in AFOV imaging. In this paper, the image quality of the developed beamformer (i.e., TSD-AFOV-PRBF) has been quantitatively evaluated using phantom and in vivo data. From the phantom study, it was found that TSD-AFOV-PRBF with only 1024 beamforming points provides comparable image quality to QD-PRBF. We obtained a median contrast resolution (CR) degradation of 7.6% for the FOV size of 160 mm. Image quality steadily improves with FOV size reduction (e.g., 2.3% CR degradation at 85 mm). Similar results were also obtained from an in vivo study. Thus, TSD-AFOV-PRBF could provide comparable image quality to conventional beamformers at considerably reduced computational cost.

Adaptive field-of-view imaging for efficient receive beamforming in medical ultrasound imaging systems.

Quadrature demodulation-based phase rotation beamforming (QD-PRBF) is commonly used to support dynamic receive focusing in medical ultrasound systems. However, it is computationally demanding since it requires two demodulation filters for each receive channel. To reduce the computational requirements of QD-PRBF, we have previously developed two-stage demodulation (TSD), which reduces the number of lowpass filters by performing demodulation filtering on summation signals. However, it suffers from image quality degradation due to aliasing at lower beamforming frequencies. To improve the performance of TSD-PRBF with reduced number of beamforming points, we propose a new adaptive field-of-view (AFOV) imaging method. In AFOV imaging, the beamforming frequency is adjusted depending on displayed FOV size and the center frequency of received signals. To study its impact on image quality, simulation was conducted using Field II, phantom data were acquired from a commercial ultrasound machine, and the image quality was quantified using spatial (i.e., axial and lateral) and contrast resolution. The developed beamformer (i.e., TSD-AFOV-PRBF) with 1024 beamforming points provided comparable image resolution to QD-PRBF for typical FOV sizes (e.g., 4.6% and 1.3% degradation in contrast resolution for 160 mm and 112 mm, respectively for a 3.5 MHz transducer). Furthermore, it reduced the number of operations by 86.8% compared to QD-PRBF. These results indicate that the developed TSD-AFOV-PRBF can lower the computational requirement for receive beamforming without significant image quality degradation.

Research interface on a programmable ultrasound scanner.

MOTIVATION: Commercial ultrasound machines in the past did not provide the ultrasound researchers access to raw ultrasound data. Lack of this ability has impeded evaluation and clinical testing of novel ultrasound algorithms and applications. OBJECTIVES: Recently, we developed a flexible ultrasound back-end where all the processing for the conventional ultrasound modes, such as B, M, color flow and spectral Doppler, was performed in software. The back-end has been incorporated into a commercial ultrasound machine, the Hitachi HiVision 5500. The goal of this work is to develop an ultrasound research interface on the back-end for acquiring raw ultrasound data from the machine. METHODS: The research interface has been designed as a software module on the ultrasound back-end. To increase the amount of raw ultrasound data that can be spooled in the limited memory available on the back-end, we have developed a method that can losslessly compress the ultrasound data in real time. RESULTS AND DISCUSSION: The raw ultrasound data could be obtained in any conventional ultrasound mode, including duplex and triplex modes. Furthermore, use of the research interface does not decrease the frame rate or otherwise affect the clinical usability of the machine. The lossless compression of the ultrasound data in real time can increase the amount of data spooled by approximately 2.3 times, thus allowing more than 6s of raw ultrasound data to be acquired in all the modes. The interface has been used not only for early testing of new ideas with in vitro data from phantoms, but also for acquiring in vivo data for fine-tuning ultrasound applications and conducting clinical studies. We present several examples of how newer ultrasound applications, such as elastography, vibration imaging and 3D imaging, have benefited from this research interface. Since the research interface is entirely implemented in software, it can be deployed on existing HiVision 5500 ultrasound machines and may be easily upgraded in the future. CONCLUSIONS: The developed research interface can aid researchers in the rapid testing and clinical evaluation of new ultrasound algorithms and applications. Additionally, we believe that our approach would be applicable to designing research interfaces on other ultrasound machines.

New multi-volume rendering technique for three-dimensional power Doppler imaging.

In this paper, we present a new multi-volume rendering technique (i.e., progressive fusion) to combine 3D anatomical structures from B-mode imaging and flow information from power Doppler imaging. A post-fusion technique, in which B-mode and power Doppler volumes are independently rendered and then fused based on alpha blending, is typically used in 3D power Doppler imaging. However, it has limitations in preserving the spatial relationship (i.e., depth order) between tissue structure and vasculature since they are rendered independently and then merged. With the proposed progressive fusion, B-mode and power Doppler volumes are composited together while rendering by sharing the opacity values. After compositing, two rendered frames are blended by utilizing a 2D color lookup table designed to fuse two properties (i.e., tissues and blood flows). We have evaluated the progressive-fusion multi-volume rendering method with the phantom and in vivo data acquired using a commercial ultrasound machine (EUB-8500, Hitachi Medical Corporation, Japan) with a 3.5 MHz mechanical probe. From the preliminary study, we have found that the new progressive-fusion method can better retain and display the spatial relationship between tissue structure, vasculature and their corresponding depth order.

New adaptive clutter rejection based on spectral analysis in ultrasound color-flow imaging.

We have developed a new adaptive clutter rejection technique where an optimum clutter filter is dynamically selected according to the varying clutter characteristics in ultrasound color-flow imaging. The selection criteria have been established based on spectral analysis of an estimate of the temporal autocorrelation matrix of clutter signals. The performance of the clutter rejection techniques is quantified from a wall-less flow phantom and in vivo studies. The in vivo color-flow images obtained from hepatic veins are presented to illustrate the potential of the proposed adaptive clutter rejection technique. In hepatic vein in vivo studies, we obtained an average gain of 4.1 dB and 3.4 dB in flow signal-to-clutter-ratio compared to the conventional and down-mixing methods, respectively.