Detalhe da pesquisa
1.
Triphenylphosphonium conjugation to a TRAP1 inhibitor, 2-amino-6-chloro-7,9-dihydro-8H-purin-8-one increases antiproliferative activity.
Bioorg Chem
; 126: 105856, 2022 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35661618
2.
Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site.
J Am Chem Soc
; 143(47): 19684-19696, 2021 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34758612
3.
Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1.
Bioorg Med Chem Lett
; 30(2): 126809, 2020 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31839539
4.
Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models.
Bioorg Chem
; 101: 103901, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32590225
5.
Correction to "Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site".
J Am Chem Soc
; 144(4): 2020, 2022 Feb 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35044746
6.
Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy.
Adv Sci (Weinh)
; 11(2): e2302776, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-37983591
7.
Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.
ACS Med Chem Lett
; 12(7): 1173-1180, 2021 Jul 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34267888
8.
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1.
Exp Mol Med
; 52(1): 79-91, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31956271
9.
Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug.
J Med Chem
; 63(6): 2930-2940, 2020 03 26.
Artigo
Inglês
| MEDLINE | ID: mdl-32068404