Detalhe da pesquisa
1.
Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors.
Bioorg Med Chem
; 26(14): 4001-4013, 2018 08 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29945757
2.
Pitavastatin increases ABCA1 expression by dual mechanisms: SREBP2-driven transcriptional activation and PPARα-dependent protein stabilization but without activating LXR in rat hepatoma McARH7777 cells.
J Pharmacol Sci
; 116(1): 107-15, 2011.
Artigo
Inglês
| MEDLINE | ID: mdl-21521932
3.
Discovery of Clinical Candidate 2-(4-(2-((1 H-Benzo[ d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)- N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor.
J Med Chem
; 61(23): 10635-10650, 2018 12 13.
Artigo
Inglês
| MEDLINE | ID: mdl-30433781
4.
A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels.
Atherosclerosis
; 191(2): 290-7, 2007 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-16820149
5.
Mechanism of lipid-lowering action of the dipeptidyl peptidase-4 inhibitor, anagliptin, in low-density lipoprotein receptor-deficient mice.
J Diabetes Investig
; 8(2): 155-160, 2017 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-27860391
6.
Triglyceride-lowering effect of pitavastatin [corrected] in a rat model of postprandial lipemia.
Eur J Pharmacol
; 444(1-2): 107-13, 2002 May 24.
Artigo
Inglês
| MEDLINE | ID: mdl-12191589
7.
Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells.
PLoS One
; 9(5): e96005, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24797675
8.
A selective ACAT-1 inhibitor, K-604, stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein E-knockout mice.
Atherosclerosis
; 213(1): 85-91, 2010 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-20843517