Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 82
Filtrar
1.
Int J Health Plann Manage ; 36(3): 911-924, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33683728

RESUMO

We examine the relationship between national health expenditure and its drivers to help inform resource allocation policy decisions in Palestine. We forecast health expenditures from the financing agency perspective, and examine Granger-Causality relationships to assess implied causality between health spending and exogenous variables, using estimates of vector autoregressions. We forecast national health expenditure to be US$1.45 billion in 2015 and grow at 7% annually through 2020. This is due to expected increases in government health expenditure, and household spending, at 5% and 7%, respectively, compared to 2014. The proportion of household spending on health services is expected to increase, while the government proportion is expected to decrease over the long run due to budget constraints. Population growth, ageing and changes in chronic disease patterns contribute significantly as drivers of the increase in healthcare costs. Our results suggest a need to review and modify the current health insurance scheme.


Assuntos
Financiamento Governamental , Gastos em Saúde , Custos de Cuidados de Saúde , Serviços de Saúde , Seguro Saúde
2.
Mo Med ; 116(4): 331-335, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31527984

RESUMO

A 24/7 intensivist model may improve important outcomes such as mortality, length of stay, and number of ventilator days. In this retrospective, single-center study at Saint Luke's Hospital in Kansas City, Missouri, we examined patient outcomes before and after adopting a 24/7 model from 2014 to 2016. The addition of a nighttime intensivist did not lead to a statistically significant improvement in mortality (hospital and ICU) and LOS (hospital and ICU).


Assuntos
Médicos Hospitalares/organização & administração , Unidades de Terapia Intensiva/organização & administração , Idoso , Cuidados Críticos/organização & administração , Cuidados Críticos/estatística & dados numéricos , Resultados de Cuidados Críticos , Feminino , Mortalidade Hospitalar , Médicos Hospitalares/estatística & dados numéricos , Humanos , Unidades de Terapia Intensiva/estatística & dados numéricos , Tempo de Internação/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Missouri , Admissão e Escalonamento de Pessoal , Estudos Retrospectivos
3.
J Child Sex Abus ; 27(2): 122-140, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29488829

RESUMO

Tourism marriage in Egypt is considered a part of the child marriage phenomenon, as parents following false interpretations of Islamic teachings offer up their daughters for short-term sexual relationships in return for money from tourists. This exploratory study used qualitative methods to interview 42 parents who reside in the city of Darasa, Giza, Egypt, whose daughters were persuaded to engage in tourism marriage. Eight social work students utilized an interview guide that contained 10 questions exploring how parents strike deals with tourists and avoid all legal and traditional procedures of marriage in Egypt. The findings of this study were summarized in six distinct themes, which show evidence of family exploitation of young women. This experience likely increases the child's vulnerability to psychological, social, and physical consequences.


Assuntos
Abuso Sexual na Infância , Maus-Tratos Infantis , Casamento , Adolescente , Egito , Feminino , Humanos , Comportamento Sexual
4.
Lancet ; 388(10049): 1081-1088, 2016 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-27394647

RESUMO

BACKGROUND: With recent improvements in vaccines and treatments against viral hepatitis, an improved understanding of the burden of viral hepatitis is needed to inform global intervention strategies. We used data from the Global Burden of Disease (GBD) Study to estimate morbidity and mortality for acute viral hepatitis, and for cirrhosis and liver cancer caused by viral hepatitis, by age, sex, and country from 1990 to 2013. METHODS: We estimated mortality using natural history models for acute hepatitis infections and GBD's cause-of-death ensemble model for cirrhosis and liver cancer. We used meta-regression to estimate total cirrhosis and total liver cancer prevalence, as well as the proportion of cirrhosis and liver cancer attributable to each cause. We then estimated cause-specific prevalence as the product of the total prevalence and the proportion attributable to a specific cause. Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost (YLLs) and years lived with disability (YLDs). FINDINGS: Between 1990 and 2013, global viral hepatitis deaths increased from 0·89 million (95% uncertainty interval [UI] 0·86-0·94) to 1·45 million (1·38-1·54); YLLs from 31·0 million (29·6-32·6) to 41·6 million (39·1-44·7); YLDs from 0·65 million (0·45-0·89) to 0·87 million (0·61-1·18); and DALYs from 31·7 million (30·2-33·3) to 42·5 million (39·9-45·6). In 2013, viral hepatitis was the seventh (95% UI seventh to eighth) leading cause of death worldwide, compared with tenth (tenth to 12th) in 1990. INTERPRETATION: Viral hepatitis is a leading cause of death and disability worldwide. Unlike most communicable diseases, the absolute burden and relative rank of viral hepatitis increased between 1990 and 2013. The enormous health loss attributable to viral hepatitis, and the availability of effective vaccines and treatments, suggests an important opportunity to improve public health. FUNDING: Bill & Melinda Gates Foundation.


Assuntos
Expectativa de Vida , Anos de Vida Ajustados por Qualidade de Vida , Efeitos Psicossociais da Doença , Pessoas com Deficiência , Saúde Global , Hepatite , Humanos , Morbidade
5.
J Health Hum Serv Adm ; 39(2): 159-85, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-29388757

RESUMO

Global disparities in health form a complex issue adversely affecting much of the world's population. What has been found is that national income and other general socio-economic factors are strong determinants of population health (Houweling, 2005 & Schell, 2007). In countries where resources are less, people are much less healthy than people living in rich countries. In wealthier countries that have made immense progress in health indicators, the resulting change in age structure and morbidity and mortality patterns portends even greater financial demands on the health sector. This study noted the trends in several health indicators versus economic indicators and related it to low income, lower middle income, upper middle income and high income countries. We noted that there is improvement in all health indicators along with an increasing GNI per Capita and GDP. In low income regions though, the rate of improvement is slower as opposed to high income countries. However, there is progress, which is leading to an increase in aging population.


Assuntos
Saúde Global , Produto Interno Bruto , Disparidades nos Níveis de Saúde , Renda/estatística & dados numéricos , Mortalidade Infantil/tendências , Países Desenvolvidos/economia , Países em Desenvolvimento/economia , Indicadores Básicos de Saúde , Humanos , Lactente , Recém-Nascido , Expectativa de Vida
6.
J Health Hum Serv Adm ; 39(1): 95-121, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27483976

RESUMO

The United Arab Emirate (UAE) of Dubai, faces significant adolescent health problems. In 2009, evidence based clinical guidelines were developed for primary health care professionals in Dubai to help reduce adolescent health problems. This research study explores adolescents' self-reports about health education services received between 2008 and 2010. The sample consisted of 730 public high school students in grades 10 through 12 between the ages of 15 and 19. 357 (48.9%) of the sample were males and 373 (51.1%) were female. The major language spoken in the home was Arabic (77.4%). All students completed a 27-item survey in Arabic that was adapted from the Young Adult Health Care Survey (YAHCS). The YAHCS is a 56-item research instrument traditionally administered in English and Spanish. The sample reported they had received little or no health education from their health care providers. 94.2% reported receiving no information about using a helmet for bicycle and motorbike safety; 88.2% reported receiving no information about drug use; and 81.9% reported that they received no information about smoking. The instrument also explored the health education material students received within the last 12 months. 65.5% of the sample reported seeing and/or hearing safety tips; 84.9% reported hearing and/or seeing health information about healthy diet, physical activity and exercise; and 79.2% reported seeing and/or hearing information about the risks of smoking and substance abuse.


Assuntos
Serviços de Saúde do Adolescente/organização & administração , Serviços Preventivos de Saúde/organização & administração , Adolescente , Serviços de Saúde do Adolescente/estatística & dados numéricos , Feminino , Pesquisa sobre Serviços de Saúde , Indicadores Básicos de Saúde , Humanos , Masculino , Serviços Preventivos de Saúde/estatística & dados numéricos , Inquéritos e Questionários , Emirados Árabes Unidos
7.
J Health Care Finance ; 40(3): 86-100, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25223161

RESUMO

The demographic factors of the United Arab Emirates (UAE) have changed drastically within one generation. This is evident in how quickly it has moved from a developing nation, where fishing was once the main source of income, to a country that is quite developed, competing on a global level. From one perspective, socio-economic progress has brought many benefits to the population. These include improved education, better access to health care, and safe drinking water. However, on the other hand, economic development has been the cause for changes in lifestyles, eating habits, and traditional societal and family structures. Over time, these changes have added up, creating an unprecedented impact on the population's health. This impact has crept up onto the society until suddenly a notable epidemic has become recognized in the country. According to the UAE Ministry of Health, 19.5 percent of the UAE population has diabetes, making it the second highest rate in the world. The structure and responsibilities of the current UAE health care systems along with other cultural factors were investigated in order to determine their impact on the growing epidemic.


Assuntos
Atenção à Saúde , Política de Saúde , Saúde Pública , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Envelhecimento , Criança , Pré-Escolar , Atenção à Saúde/organização & administração , Atenção à Saúde/normas , Diabetes Mellitus/epidemiologia , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Lactente , Masculino , Casamento/tendências , Pessoa de Meia-Idade , Obesidade/epidemiologia , Setor Privado , Emirados Árabes Unidos/epidemiologia , Adulto Jovem
8.
J Health Care Finance ; 40(3): 47-66, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25223159

RESUMO

INTRODUCTION: The Emirate of Abu Dhabi has taken concrete steps to reform health insurance by improving the access to health providers as well as freedom of choice. The growing cost of health care and the impact of the global financial crisis have meant that countries are no longer able to solely bear the cost. As a result many countries have sought to overhaul their health care system so as to share the burden of provision with the private sector whether it is health care plan providers or employers. OBJECTIVES: This article explores and discusses how the policy issues inherent in private health care schemes have been dealt with by the Emirate of Abu Dhabi. METHODS: Data was collected in early 2013 on health care plans in Abu Dhabi from government sources. RESULTS: The Abu Dhabi model has private sector involvement but the government sets prices and benefits. The Abu Dhabi model adequately deals with the problem of adverse selection through making insurance coverage a mandatory requirement. There are issues with moral hazards, which are a combination of individual and medical practitioner behavior that might affect the efficiency of the system. Over time there is a general increase in the usage of medical services, which may be reflective of greater awareness of the policy and its benefits as well as lifestyle change. CONCLUSION: Although the current health care system level of usage is adequate for the current population, as the level of usage increases, the government may face a financial burden. Therefore, the government needs to place safeguards in order to limit its exposure. The market for medical treatment needs to be made more competitive to reduce monopolistic behavior. The government needs to make individuals aware of a healthier lifestyle and encourage precautionary actions.


Assuntos
Reforma dos Serviços de Saúde , Cobertura do Seguro/organização & administração , Seguro Saúde/organização & administração , Setor Privado , Desenvolvimento de Programas , Setor Público , Emirados Árabes Unidos
9.
Healthcare (Basel) ; 12(3)2024 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-38338175

RESUMO

OBJECTIVE: In the age of digital transformation, there is a need for a sustainable information management vision in health. Understanding the accumulation of health information management (HIM) knowledge from the past to the present and building a new vision to meet this need reveals the importance of understanding the available scientific knowledge. With this research, it is aimed to examine the scientific documents of the last 40 years of HIM literature with a holistic approach using science mapping techniques and to guide future research. METHODS: This study used a bibliometric analysis method for science mapping. Co-citation and co-occurrence document analyses were performed on 630 academic publications selected from the Web of Science core collection (WoSCC) database using the keyword "Health Information Management" and inclusion criteria. The analyses were performed using the R-based software Bibliometrix (Version 4.0; K-Synth Srl), Python (Version 3.12.1; The Python Software Foundation), and Microsoft® Excel® 2016. RESULTS: Co-occurrence analyses revealed the themes of personal health records, clinical coding and data quality, and health information management. The HIM theme consisted of five subthemes: "electronic records", "medical informatics", "e-health and telemedicine", "health education and awareness", and "health information systems (HISs)". As a result of the co-citation analysis, the prominent themes were technology acceptance, standardized clinical coding, the success of HISs, types of electronic records, people with HIM, health informatics used by consumers, e-health, e-mobile health technologies, and countries' frameworks and standards for HISs. CONCLUSIONS: This comprehensive bibliometric study shows that structured information can be helpful in understanding research trends in HIM. This study identified critical issues in HIM, identified meaningful themes, and explained the topic from a holistic perspective for all health system actors and stakeholders who want to work in the field of HIM.

10.
Int J Health Plann Manage ; 28(4): 320-32, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23125096

RESUMO

BACKGROUND: Many factors have affected the rise of health expenditures, such as high-cost medical technologies, changes in disease patterns and increasing demand for health services. All countries allocate a significant portion of resources to the health sector. In 2008, the gross domestic product of Palestine was estimated to be at $6.108bn (current price) or about $1697 per capita. Health expenditures are estimated at 15.6% of the gross domestic product, almost as much as those of Germany, Japan and other developed countries. The numbers of hospitals, hospital beds and primary healthcare centers in the country have all increased. The Ministry of Health (MOH) currently operates 27 of 76 hospitals, with a total of 3074 beds, which represent 61% of total beds of all hospitals in the Palestinian Authorities area. Also, the MOH is operating 453 of 706 Primary Health Care facilities. By 2007, about 40 000 people were employed in different sectors of the health system, with 33% employed by the MOH. AIM: This purpose of this study was to develop a financing strategy to help cover some or all of the costs involved in operating such institutions and to estimate the unit cost of primary and secondary programs and departments. METHODS: A retrospective study was carried out on data from government hospitals and primary healthcare centers to identify and analyze the costs and output (patient-related services) and to estimate the unit cost of health services provided by hospitals and PHCs during the year 2008. All operating costs are assigned and allocated to the departments at MOH hospitals and primary health care centers (PPHCs) and are identified as overhead departments, intermediate-service and final-service departments. Intermediate-service departments provide procedures and services to patients in the final-service departments. The costs of the overhead departments are distributed to the intermediate-service and final-service departments through a step-down method, according to allocation criteria devised to resemble as closely as possible the actual use of resources by each of the departments. The data were analyzed using spss. Data cleaning was carried out by cross-validating the results through conducting cross-tabulations between the hospital/center and section/program to identify errors from the data collection or entry process. Depreciation of assets and the consumption of capital costs are ignored in this study, as it is difficult to evaluate the MOH facilities owing to a lack of recording of depreciation of assets or other costs of servicing capital assets. RESULTS: Inpatient costs contributed about 75% of all costs, whereas outpatient services contributed the remaining 25% of total costs. The average cost per visit was $13.00 for outpatient departments, whereas the average cost per patient day for inpatient departments was $90.00. As for the unit cost for each department, intensive care unit and intermediate care unit services were the highest among all categories of daily hospital services ($208.00). This is in contrast to surgical operations ($124.00), specialized surgeries ($106.00), delivery department ($99.00), orthopedics ($98.50) and general surgery ($85.00). The lowest unit cost was found in the neonatology department ($72.00). In PHCs, the unit cost per visit was highest for psychiatry programs ($26.00), followed by other programs ($21.50), chronic diseases ($21.00), maternal and child health ($11.50), preventive programs ($9.00) and general medicine ($6.50). The exchange rate listed by The Wall Street Journal as of Wednesday August 25, 2010 is 1 US dollar = 3.82 new Israeli shekel (NIS). CONCLUSION: The findings have implications for policy and decision making in the health sector in Palestine concerning the cost of services provided by hospitals and PHCs. The availability of a standardized data set for cost assessment would greatly enhance and improve the quality of financial information as well as efficiency in the use of scarce resources.


Assuntos
Necessidades e Demandas de Serviços de Saúde , Custos Hospitalares , Hospitais Públicos/economia , Atenção Primária à Saúde/economia , Árabes , Custos Hospitalares/organização & administração , Humanos , Estudos Retrospectivos
11.
J Health Care Finance ; 40(1): 93-102, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24199521

RESUMO

OBJECTIVES: Medication errors and adverse drug events (ADEs) are common, costly, and clinically important problems. This research was conducted to determine whether computerized physician order entry (CPOE) improves the quality of care by increasing patient safety and decreasing medication errors at the King Fahad Medical City Hospital (KFMCH) of the Kingdom of Saudi Arabia (KSA). METHODS: The study utilized a cross-sectional research design. Questionnaires were distributed to physicians in various departments who used the system for more than six months. The study was conducted in Riyadh at KFMCH, which is the largest medical complex hospital in the Middle East, in the outpatient setting. KEY FINDINGS: Ninety-three physicians participated in the study; the response rate was 31 percent. Only descriptive analyses were conducted. Results showed that 88 percent of the physicians agreed that the use of CPOE improved their performance and 76 percent reported that the use of CPOE increased their productivity. In addition, 56 percent of the participants agreed that CPOE was a simple system and 64 percent reported that it was easy to use. However, 44 percent of the physicians agreed that CPOE lacked a user guide during medication ordering and 55 percent reported that it created new types of errors. Results showed that 234 physicians always changed their order, 179 physicians changed their order often, 175 physicians rarely changed their order, and 74 physicians never changed their order. Furthermore, 72 percent of the physicians agreed that CPOE helped them to decrease ADEs. Finally, 91 percent of the physicians agreed that CPOE reduced errors related to hand-written prescriptions.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/prevenção & controle , Sistemas de Registro de Ordens Médicas , Erros de Medicação/prevenção & controle , Padrões de Prática Médica , Interface Usuário-Computador , Atitude do Pessoal de Saúde , Estudos Transversais , Pesquisas sobre Atenção à Saúde , Humanos , Arábia Saudita
12.
J Health Care Finance ; 40(2): 42-58, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24551961

RESUMO

The level of competition among hospitals in Turkey was analyzed for the years 1990 through 2006 using the Herfindahl-Hirschman Index (HHI). Multiple and simple regression analyses were run to observe the development of competition among hospitals over this period of time, to examine likely determinants of competition, and to calculate the effects of competition on efficiency and quality in individual hospitals. This study found that the level of competition among hospitals in Turkey has increased throughout the years. Also, competition has had a positive effect on the efficiency of hospitals; however, it did not have a significant positive effect on their quality. Moreover, there are important differences in the level of competition among hospitals that vary according to the geographical region, the type of ownership, and the type of hospital. This study is one of the first to evaluate the effects of health policies on competition as well as the effects of increasing competition on hospital quality and efficiency in Turkey.


Assuntos
Acessibilidade aos Serviços de Saúde/normas , Hospitais Privados/economia , Hospitais Públicos/economia , Ambulatório Hospitalar/economia , Qualidade da Assistência à Saúde/economia , Competição Econômica , Eficiência Organizacional/economia , Financiamento Pessoal , Acessibilidade aos Serviços de Saúde/tendências , Hospitais Privados/organização & administração , Hospitais Privados/tendências , Hospitais Públicos/organização & administração , Hospitais Públicos/tendências , Humanos , Ambulatório Hospitalar/organização & administração , Ambulatório Hospitalar/tendências , Satisfação do Paciente , Análise de Regressão , Turquia
13.
J Health Care Finance ; 39(4): 44-54, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24003761

RESUMO

The purpose of this study is to develop an estimation model for health care costs and cost recovery, and evaluate service sustainability under an uncertain environment. The Palestinian National Authority's recent focus on improving financial accountability supports the need to research health care costs in the Palestinian territories. We examine data from Rafidya Hospital from 2005-2009 and use step-down allocation to distribute overhead costs. We use an ingredient approach to estimate the costs and revenues of health services, and logarithmic estimation to prospectively estimate the demand for 2011. Our results indicate that while cost recovery is generally insufficient for long-term sustainability, some services can recover their costs in the short run. Our results provide information useful for health care policy makers in setting multiple-goal policies related to health care financing in Palestine, and provide an important initiative in the estimation of health service costs.


Assuntos
Economia Hospitalar/organização & administração , Alocação de Custos/economia , Hospitais Urbanos , Israel , Modelos Econômicos , Estudos de Casos Organizacionais , Estudos Retrospectivos
14.
J Health Care Finance ; 40(2): 17-41, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24551960

RESUMO

The aim of this article is to present an e-health model that embeds empowerment and social network intervention that may extend the role of customers in health care settings. A 25-item Likert-type survey instrument was specifically developed for this study and administered to a sample of 108 participants in Indonesia from October to November 2012. The data were analyzed to provide ideas on how to move forward with the e-health initiative as a means to improve e-health services. The survey revealed that there is a high demand for customers' empowerment and involvement in social networks to improve their health literacy and customer satisfaction. Regardless of the limitations of the study, the participants have responded with great support for the abilities of the prototype systems drawn from the survey. The survey results were used as requirements to develop a system prototype that incorporates the expectations of the people. The prototype (namely Clinic 2.0) was derived from the model and confirmed from the survey. Participants were selected to use the system for three months, after which we measured its impact towards their health literacy and customer satisfaction. The results show that the system intervention through Clinic 2.0 leads to a high level of customer satisfaction and health literacy.


Assuntos
Comportamento do Consumidor , Informação de Saúde ao Consumidor/métodos , Letramento em Saúde/métodos , Rede Social , Telemedicina/métodos , Adulto , Relações Comunidade-Instituição , Feminino , Humanos , Indonésia , Internet , Masculino , Pessoa de Meia-Idade , Participação do Paciente , Poder Psicológico , Inquéritos e Questionários , Adulto Jovem
15.
Front Public Health ; 11: 1123759, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37139401

RESUMO

Introduction: The consistent increase in health expenditures is an integral part of health policy. The aim of this study was to investigate the impact of health expenditures on health outcomes in the OECD countries. Method: We used the system generalized method of moments (GMM) for thirty eight OECD countries using panel data from 1996 to 2020. Results and discussion: The findings show that health expenditures have a negative impact on infant mortality while positive on life expectancy. The results further verify that the income measured as GDP, number of doctors, and air pollution has a negative effect on infant mortality, while these variables have a positive effect on life expectancy in the studied countries. The outcome of the study suggests that health expenditures need to be properly utilized and improvements can be made in the health policies to increase the investment in health technology. The government should also focus on measures like economic and environmental to have long-lasting health outcomes.


Assuntos
Gastos em Saúde , Organização para a Cooperação e Desenvolvimento Econômico , Lactente , Humanos , Mortalidade Infantil , Governo , Avaliação de Resultados em Cuidados de Saúde
16.
Healthcare (Basel) ; 11(18)2023 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-37761785

RESUMO

The purpose of this study was to evaluate the financial performances of the publicly held healthcare companies in crisis periods in Türkiye. The 2018 economic crisis and the COVID-19 pandemic crisis were included in the study as the crisis periods. We collected the financial data of the publicly held healthcare companies and calculated three liquidity, three turnover, three leverage and three profitability ratios through ratio analysis to use as financial performance indicators. We then conducted Wilcoxon signed-rank tests and we performed separate analyses for the 2018 economic crisis and the COVID-19 pandemic crisis. The results of the analyses showed that there were no statistically significant differences between the publicly held healthcare companies' liquidity, turnover, leverage, profitability ratios and thus their financial performances before the crises and after the crises. While the results are reassuring and give valuable insights to managers and policy makers to determine the areas that needs to be strengthened to be better prepared for possible future crises, our sample was limited. Therefore, this study presents an exploratory foundation for future studies which are needed to make a case for financial stability for the publicly held healthcare companies before and after the crisis periods.

17.
Egypt J Immunol ; 30(2): 119-130, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-37031414

RESUMO

Severe COVID-19 disease was linked to a severe proinflammatory response and cytokine storm interleukin 17 (IL-17) is one of these cytokines, was associated with severe acute lung injury and multiorgan dysfunction. Single nucleotide polymorphisms (SNPs) in genes coding IL-17 can affect level of IL-17 hence its role in diseases. Also, SNPs in IL-23 R which control IL-23 is the main activator of IL-17 production. This study aimed to determine whether the IL-17A (G/A-rs2275913), IL-23R (A/G rs11209026) SNPs and serum levels of IL-17 were related to the risk of severe COVID-19. This case-control study included 120 confirmed COVID-19 patients, divided into two categories according to the severity of the disease and 74 normal subjects as controls. COVID-19 patients were SARS-CoV-2 positive by a reverse transcription-polymerase chain reaction and subjected to full clinical examinations, routine laboratory tests, and radiographic evaluations. The IL-17 levels were assessed using ELISA method, and genotyping of IL-17A (197 A/G; rs2275913) and IL-23R rs11209026 (A/G) was performed by the TaqMan Genotyping Assay. There were no differences in the distribution of IL-17A or IL-23R genotypes between COVID-19 groups and the control group (p=0.93 and p=0.84, respectively). Severe COVID-19 patients had significantly higher IL-17 serum levels than non-severe COVID-19 (p=0.0001). The GG genotypes of IL-17A were significantly higher in severe COVID-19 patients (p=0.004). Multivariate logistic regression analysis revealed that AG, GG genotypes of IL-17 and IL-17A were independent predictors of COVID-19 disease severity (p < 0.0001, p=0.06 and p=0.04, respectively). ROC curve analysis for IL-17, as predictor of severe COVID-19 disease revealed a sensitivity of 87.9% and specificity of 66.1% at a cutoff point of 114 pg/ml with AUC = 0.799. In conclusion, these findings indicated that IL-17 may be considered a marker of severe COVID-19. IL-17A SNPs may have a role in COVID-19 severity. IL-23R SNPs had no role in COVID-19.


Assuntos
COVID-19 , Interleucina-17 , Humanos , Interleucina-17/genética , Predisposição Genética para Doença , Estudos de Casos e Controles , COVID-19/genética , SARS-CoV-2 , Genótipo , Polimorfismo de Nucleotídeo Único , Interleucina-23/genética
18.
Cell Physiol Biochem ; 30(3): 575-86, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22832156

RESUMO

BACKGROUND/AIMS: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic ß-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion. However, it is unknown how CaR activation improves ß-cell function. METHODS: Immunocytochemistry and western blotting confirmed the expression of CaR in MIN6 ß-cell line. The calcimimetic R568 (1µM) was used to increase the affinity of the CaR and specifically activate the receptor at a physiologically appropriate extracellular calcium concentration. Incorporation of 5-bromo-2'-deoxyuridine (BrdU) was used to measure cell proliferation, whilst changes in non-nutrient-evoked cytosolic calcium were assessed using fura-2-microfluorimetry. AFM-single-cell-force spectroscopy related CaR-evoked changes in epithelial (E)-cadherin expression to improved functional tethering between coupled cells. RESULTS: Activation of the CaR over 48hr doubled the expression of E-cadherin (206±41%) and increased L-type voltage-dependent calcium channel expression by 70% compared to control. These changes produced a 30% increase in cell-cell tethering and elevated the basal-to-peak amplitude of ATP (50µM) and tolbutamide (100µM)-evoked changes in cytosolic calcium. Activation of the receptor also increased PD98059 (1-100µM) and SU1498 (1-100µM)-dependent ß-cell proliferation. CONCLUSION: Our data suggest that activation of the CaR increases E-cadherin mediated functional tethering between ß-cells and increases expression of L-type VDCC and secretagogue-evoked changes in [Ca(2+)](i). These findings could explain how local changes in calcium, co-released with insulin, activate the CaR on neighbouring cells to help ensure efficient and appropriate secretory function.


Assuntos
Calcimiméticos/farmacologia , Adesão Celular/efeitos dos fármacos , Receptores de Detecção de Cálcio/metabolismo , Trifosfato de Adenosina/farmacologia , Animais , Caderinas/metabolismo , Cálcio/metabolismo , Canais de Cálcio Tipo L/metabolismo , Linhagem Celular , Proliferação de Células/efeitos dos fármacos , Cinamatos/farmacologia , Flavonoides/farmacologia , Hipoglicemiantes/farmacologia , Imuno-Histoquímica , Células Secretoras de Insulina/metabolismo , Camundongos , Tolbutamida/farmacologia
19.
J Health Care Finance ; 39(1): 12-38, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23155742

RESUMO

Due to the market turbulence facing the hospital industry, the financial viability of teaching hospitals has been severely threatened. Their missions of education, research, and patient care even strengthen this crisis. Therefore, the objective of this study is to conduct a comparative analysis of the cost, volume, and profit (CVP) structure between large nonprofit urban teaching hospitals and small for-profit rural/suburban non-teaching hospitals. The following two hypotheses were developed: (1) large nonprofit urban teaching hospitals tend to have higher fixed cost, lower variable cost, lower total revenue adjusted by case mix index (CMI), and lower return on total assets (ROA); and (2) small for-profit rural/suburban non-teaching hospitals tend to have lower fixed cost, higher variable cost, higher total revenue adjusted by CMI, and higher ROA. Using 117 teaching hospitals and 102 non-teaching hospitals selected from the Medicare Cost Report database in 2005, the results from multiple regression indicated that large nonprofit teaching hospitals located in urban areas are more likely to have higher fixed cost and lower variable cost. While such cost structure doesn't necessarily affect their total revenue adjusted by CMI, it does lead to a lower return on hospitals' total assets. The results support our hypotheses in terms of fixed cost percentage, variable cost percentage, and ROA, but not total revenue adjusted by CMI. The results suggest that cost structure is significantly associated with hospitals' performance. Also, as teaching hospitals' portfolios of services and programs increase (e.g., provision of uncompensated care to Medicare and Medicaid patients and doing research), it becomes strategically necessary and critical to manage the allocation of resources or investments into the fixed capital that supports the business.


Assuntos
Administração Financeira de Hospitais/organização & administração , Hospitais com Fins Lucrativos/economia , Hospitais de Ensino/economia , Hospitais Filantrópicos/economia , Custos e Análise de Custo/estatística & dados numéricos , Eficiência Organizacional/economia , Tamanho das Instituições de Saúde , Hospitais Rurais/economia , Hospitais Urbanos/economia , Renda , Reembolso de Seguro de Saúde , Programas de Assistência Gerenciada , Medicaid/economia , Medicare/economia , Análise de Regressão , Cuidados de Saúde não Remunerados , Estados Unidos
20.
Healthcare (Basel) ; 10(6)2022 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-35742055

RESUMO

Experiences in family, school, and social life during childhood are associated with gender roles and occupational choice capability. This study examines how competent individuals are in occupational choice capability and the relationships of childhood experiences and gender roles with their competencies in occupational choice capability. The research is composed of 805 individuals aged 18 and older, who reside in Turkey. In the research, we used the Personal Information Form, Childhood Experiences Scale, Gender Roles Attitude Scale, and The Scale of Occupational Choice Capability. The SPSS 25 program and PROCESS-Macro were used to analyze the variables. The relationship between the scales was investigated using Pearson correlation analysis and multiple regression analysis. According to the findings we obtained, individuals' family and school life were positively correlated with their career choices, and family function sexism harmed their choice of profession. We also found gender roles had a mediating role in the relationship between school life and career choice.

SELEÇÃO DE REFERÊNCIAS
Detalhe da pesquisa