1.
Steroids
; 85: 1-5, 2014 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24582707
RESUMO
A very efficient and environmentally benign method has been developed for the synthesis of 25-hydroxycholesterol. The reaction was performed in THF-water (4:1, v/v) using NBS as the brominating agent, followed by the easy reduction of C-Br with lithium aluminum hydride in THF, to yield the final product corresponding to a Markovnikov's rule. Excellent yields and regioselectivity have been obtained.