Detalhe da pesquisa
1.
Orexin 2 receptor-selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients.
Proc Natl Acad Sci U S A
; 119(35): e2207531119, 2022 08 30.
Artigo
Inglês
| MEDLINE | ID: mdl-35994639
2.
Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individuals.
J Sleep Res
; 32(5): e13878, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36934366
3.
From population to neuron: exploring common mediators for metabolic problems and mental illnesses.
Mol Psychiatry
; 26(8): 3931-3942, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33173197
4.
Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons.
Hum Mol Genet
; 27(18): 3165-3176, 2018 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29893844
5.
Intranasal oxytocin suppresses seizure-like behaviors in a mouse model of NGLY1 deficiency.
Commun Biol
; 7(1): 460, 2024 Apr 22.
Artigo
Inglês
| MEDLINE | ID: mdl-38649481
6.
The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder.
Neuron
; 111(2): 220-235.e9, 2023 01 18.
Artigo
Inglês
| MEDLINE | ID: mdl-36379214
7.
Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor Agonist.
ACS Med Chem Lett
; 13(3): 457-462, 2022 Mar 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35295087
8.
TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in mice.
Pharmacol Biochem Behav
; 187: 172794, 2019 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31654653
9.
Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System.
Oxid Med Cell Longev
; 2017: 8584930, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28191280
10.
AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis.
Biochim Biophys Acta
; 1577(1): 126-32, 2002 Aug 19.
Artigo
Inglês
| MEDLINE | ID: mdl-12151104
11.
BTZO-2, an antioxidant response element-activator, provides protection against lethal endotoxic shock in mice.
Eur J Pharmacol
; 700(1-3): 80-5, 2013 Jan 30.
Artigo
Inglês
| MEDLINE | ID: mdl-23276667
12.
BTZO-15, an ARE-activator, ameliorates DSS- and TNBS-induced colitis in rats.
PLoS One
; 6(8): e23256, 2011.
Artigo
Inglês
| MEDLINE | ID: mdl-21853095
13.
BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression.
Chem Biol
; 17(12): 1282-94, 2010 Dec 22.
Artigo
Inglês
| MEDLINE | ID: mdl-21168764
14.
ITZ-1, a client-selective Hsp90 inhibitor, efficiently induces heat shock factor 1 activation.
Chem Biol
; 17(1): 18-27, 2010 Jan 29.
Artigo
Inglês
| MEDLINE | ID: mdl-20142037
15.
The chondroprotective agent ITZ-1 inhibits interleukin-1beta-induced matrix metalloproteinase-13 production and suppresses nitric oxide-induced chondrocyte death.
J Pharmacol Sci
; 110(2): 201-11, 2009 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-19542681
16.
AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase.
J Biol Chem
; 277(47): 45480-92, 2002 Nov 22.
Artigo
Inglês
| MEDLINE | ID: mdl-12223483