Detalhe da pesquisa
1.
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor.
J Pharmacol Exp Ther
; 372(3): 339-353, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31818916
2.
Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8.
J Pharmacol Exp Ther
; 357(2): 394-414, 2016 May.
Artigo
Inglês
| MEDLINE | ID: mdl-26989142
3.
GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine.
Mol Pharmacol
; 88(5): 911-25, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-26349500
4.
A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects.
J Pharmacol Exp Ther
; 352(3): 590-601, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25583879
5.
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.
J Pharmacol Exp Ther
; 354(3): 471-82, 2015 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-26177655
6.
Monitoring the Outcomes of Systemic Chemotherapy Including Immune Checkpoint Inhibitor for HER2-Positive Metastatic Gastric Cancer by Liquid Biopsy.
Yonsei Med J
; 64(9): 531-540, 2023 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-37634629
7.
A dual-targeting antibody against EGFR-VEGF for lung and head and neck cancer treatment.
Int J Cancer
; 131(4): 956-69, 2012 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21918971
8.
Ginsenoside rb1 and rg3 attenuate glucocorticoid-induced neurotoxicity.
Cell Mol Neurobiol
; 30(6): 857-62, 2010 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-20336484
9.
Putative role of GPR139 on sleep modulation using pharmacological and genetic rodent models.
Eur J Pharmacol
; 882: 173256, 2020 Sep 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32531213
10.
Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.
J Pharmacol Exp Ther
; 330(1): 142-51, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-19363060
11.
5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor.
Neuropharmacology
; 56(2): 448-54, 2009 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18948124
12.
Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures.
Can J Physiol Pharmacol
; 87(6): 440-7, 2009 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-19526038
13.
Activation of microglial cells by ceruloplasmin.
Brain Res
; 1171: 1-8, 2007 Sep 26.
Artigo
Inglês
| MEDLINE | ID: mdl-17727827
14.
The water extract of adlay seed (Coix lachrymajobi var. mayuen) exhibits anti-obesity effects through neuroendocrine modulation.
Am J Chin Med
; 35(2): 297-308, 2007.
Artigo
Inglês
| MEDLINE | ID: mdl-17436369
15.
Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation.
Front Pharmacol
; 8: 357, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28649201
16.
Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice.
Front Behav Neurosci
; 11: 83, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28533747
17.
Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate.
J Med Chem
; 58(14): 5620-36, 2015 Jul 23.
Artigo
Inglês
| MEDLINE | ID: mdl-26087021
18.
Induction of TGF-beta-inducible gene-h3 (betaig-h3) by TGF-beta1 in astrocytes: implications for astrocyte response to brain injury.
Brain Res Mol Brain Res
; 107(1): 57-64, 2002 Oct 30.
Artigo
Inglês
| MEDLINE | ID: mdl-12414124
19.
Down-regulation of the expression of rat inhibitor-of-apoptosis protein-1 and -3 during transforming growth factor-beta1-mediated apoptosis in rat brain microglia.
Neuroreport
; 14(6): 857-60, 2003 May 06.
Artigo
Inglês
| MEDLINE | ID: mdl-12858047
20.
Reduction but not cleavage of poly(ADP-ribose) polymerase during stress-mediated cell death in the rat hippocampus.
Neuroreport
; 14(7): 935-9, 2003 May 23.
Artigo
Inglês
| MEDLINE | ID: mdl-12802178