Detalhe da pesquisa
1.
High-Throughput Therapeutic Antibody Interference-Free High-Resolution Mass Spectrometry Assay for Monitoring M-Proteins in Multiple Myeloma.
Anal Chem
; 93(2): 834-842, 2021 01 19.
Artigo
Inglês
| MEDLINE | ID: mdl-33300779
2.
Antipeptide Immunocapture with In-Sample Calibration Curve Strategy for Sensitive and Robust LC-MS/MS Bioanalysis of Clinical Protein Biomarkers in Formalin-Fixed Paraffin-Embedded Tumor Tissues.
Anal Chem
; 92(21): 14713-14722, 2020 11 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33047598
3.
Detection of Weak Organic Anion-Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans.
Drug Metab Dispos
; 48(10): 841-848, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32723847
4.
In-Sample Calibration Curve Using Multiple Isotopologue Reaction Monitoring of a Stable Isotopically Labeled Analyte for Instant LC-MS/MS Bioanalysis and Quantitative Proteomics.
Anal Chem
; 91(3): 2536-2543, 2019 02 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30615432
5.
Eliminating Preparation of Multisample External Calibration Curves and Dilution of Study Samples Using the Multiple Isotopologue Reaction Monitoring (MIRM) Technique in Quantitative LC-MS/MS Bioanalysis.
Anal Chem
; 91(13): 8652-8659, 2019 07 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31180205
6.
Determination of Real Time in Vivo Drug Receptor Occupancy for a Covalent Binding Drug as a Clinical Pharmacodynamic Biomarker by Immunocapture-LC-MS/MS.
Anal Chem
; 91(13): 8443-8452, 2019 07 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31247719
7.
Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation.
Drug Metab Dispos
; 44(2): 238-49, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26608080
8.
Innovative use of LC-MS/MS for simultaneous quantitation of neutralizing antibody, residual drug, and human immunoglobulin G in immunogenicity assay development.
Anal Chem
; 86(5): 2673-80, 2014 Mar 04.
Artigo
Inglês
| MEDLINE | ID: mdl-24506335
9.
Synthesis of a stable isotopically labeled universal surrogate peptide for use as an internal standard in LC-MS/MS bioanalysis of human IgG and Fc-fusion protein drug candidates.
J Labelled Comp Radiopharm
; 57(9): 579-83, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-25089024
10.
LC-MS bioanalysis of protein biomarkers and protein therapeutics in formalin-fixed paraffin-embedded tissue specimens.
Bioanalysis
; 16(4): 245-258, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-38226835
11.
2023 White Paper on Recent Issues in Bioanalysis: Deuterated Drugs; LNP; Tumor/FFPE Biopsy; Targeted Proteomics; Small Molecule Covalent Inhibitors; Chiral Bioanalysis; Remote Regulatory Assessments; Sample Reconciliation/Chain of Custody (PART 1A - Recommendations on Mass Spectrometry, Chromatography, Sample Preparation Latest Developments, Challenges, and Solutions and BMV/Regulated Bioanalysis PART 1B - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/IVD/CDx/BAV, Immunogenicity, Gene & Cell Therapy and Vaccine).
Bioanalysis
; 16(9): 307-364, 2024.
Artigo
Inglês
| MEDLINE | ID: mdl-38913185
12.
Fully validated LC-MS/MS assay for the simultaneous quantitation of coadministered therapeutic antibodies in cynomolgus monkey serum.
Anal Chem
; 85(20): 9859-67, 2013 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24024648
13.
Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.
Anal Chem
; 84(22): 10031-7, 2012 Nov 20.
Artigo
Inglês
| MEDLINE | ID: mdl-23106420
14.
Calculation and mitigation of isotopic interferences in liquid chromatography-mass spectrometry/mass spectrometry assays and its application in supporting microdose absolute bioavailability studies.
Anal Chem
; 84(11): 4844-50, 2012 Jun 05.
Artigo
Inglês
| MEDLINE | ID: mdl-22540405
15.
Esterase inhibitors as ester-containing drug stabilizers and their hydrolytic products: potential contributors to the matrix effects on bioanalysis by liquid chromatography/tandem mass spectrometry.
Rapid Commun Mass Spectrom
; 26(11): 1291-304, 2012 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22555922
16.
Development of oral extended release formulations of 6-hydroxybuspirone.
Biopharm Drug Dispos
; 33(9): 522-35, 2012 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-23065950
17.
2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC & Part 1B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine).
Bioanalysis
; 14(9): 505-580, 2022 May.
Artigo
Inglês
| MEDLINE | ID: mdl-35578993
18.
A convenient strategy for quantitative determination of drug concentrations in tissue homogenates using a liquid chromatography/tandem mass spectrometry assay for plasma samples.
Anal Chem
; 83(16): 6237-44, 2011 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21692511
19.
Preclinical Characterization of Linrodostat Mesylate, a Novel, Potent, and Selective Oral Indoleamine 2,3-Dioxygenase 1 Inhibitor.
Mol Cancer Ther
; 20(3): 467-476, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33298590
20.
Application of in-sample calibration curve methodology for regulated bioanalysis: Critical considerations in method development, validation and sample analysis.
J Pharm Biomed Anal
; 177: 112844, 2020 Jan 05.
Artigo
Inglês
| MEDLINE | ID: mdl-31491659