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Interleukin-1ß (IL-1ß) is a key protein in inflammation and contributes to tumor progression. However, the role of IL-1ß in cancer is ambiguous or even contradictory. Here, we found that upon IL-1ß stimulation, nicotinamide nucleotide transhydrogenase (NNT) in cancer cells is acetylated at lysine (K) 1042 (NNT K1042ac) and thereby induces the mitochondrial translocation of p300/CBP-associated factor (PCAF). This acetylation enhances NNT activity by increasing the binding affinity of NNT for NADP+ and therefore boosts NADPH production, which subsequently sustains sufficient iron-sulfur cluster maintenance and protects tumor cells from ferroptosis. Abrogating NNT K1042ac dramatically attenuates IL-1ß-promoted tumor immune evasion and synergizes with PD-1 blockade. In addition, NNT K1042ac is associated with IL-1ß expression and the prognosis of human gastric cancer. Our findings demonstrate a mechanism of IL-1ß-promoted tumor immune evasion, implicating the therapeutic potential of disrupting the link between IL-1ß and tumor cells by inhibiting NNT acetylation.
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NADP Trans-Hidrogenases , Neoplasias , Humanos , NADP Trans-Hidrogenases/genética , NADP Trans-Hidrogenases/metabolismo , Interleucina-1beta/genética , Interleucina-1beta/metabolismo , Acetilação , Processamento de Proteína Pós-Traducional , Imunoterapia , Neoplasias/tratamento farmacológico , Neoplasias/genéticaRESUMO
The mitochondrial citrate shuttle, which relies on the solute carrier family 25 member 1 (SLC25A1), plays a pivotal role in transporting citrate from the mitochondria to the cytoplasm. This shuttle supports glycolysis, lipid biosynthesis, and protein acetylation. Previous research has primarily focused on Slc25a1 in pathological models, particularly high-fat diet (HFD)-induced obesity. However, the impact of Slc25a1 inhibition on nutrient metabolism under HFD remains unclear. To address this gap, we used zebrafish (Danio rerio) and Nile tilapia (Oreochromis niloticus) to evaluate the effects of inhibiting Slc25a1. In zebrafish, we administered Slc25a1-specific inhibitors (CTPI-2) for four weeks, while Nile tilapia received intraperitoneal injections of dsRNA to knockdown slc25a1b for seven days. Inhibition of the mitochondrial citrate shuttle effectively protected zebrafish from HFD-induced obesity, hepatic steatosis, and insulin resistance. Notably, glucose tolerance was unaffected. Inhibition of Slc25a1 altered hepatic protein acetylation patterns, with decreased cytoplasmic acetylation and increased mitochondrial acetylation. Under HFD conditions, Slc25a1 inhibition promoted fatty acid oxidation and reduced hepatic triglyceride accumulation by deacetylating Cpt1a. Additionally, Slc25a1 inhibition triggered acetylation-induced inactivation of Pdhe1α, leading to a reduction in glucose oxidative catabolism. This was accompanied by enhanced glucose uptake and storage in zebrafish livers. Furthermore, Slc25a1 inhibition under HFD conditions activated the SIRT1/PGC1α pathway, promoting mitochondrial proliferation and enhancing oxidative phosphorylation for energy production. Our findings provide new insights into the role of non-histone protein acetylation via the mitochondrial citrate shuttle in the development of hepatic lipid deposition and hyperglycemia caused by HFD.
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Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, and then we report an efficient method to prepare Homer1a+ EVs derived from A2 astrocytes which making it more stable, safe, and targetable to injured neurons. Homer1a+ EVs promotes the conversion of A1 to A2 astrocytes in ICH mice. Homer1a+ EVs inhibits activation and nuclear translocation of NF-κB, thereby regulating transcription of IL-17A in neurons. Homer1a+ EVs inhibits the RAGE/NF-κB/IL-17 signaling pathway and the binding ability of IL-17A: IL17-AR and RAGE: DIAPH1. In addition, Homer1a+ EVs ameliorates the pathology, behavior, and survival rate in GFAPCreHomer1fl/-Homer1a± and NestinCreRAGEfl/fl ICH mice. Our study provides a novel insight and potential for the clinical translation of Homer1a+ EVs in the treatment of ICH.
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Vesículas Extracelulares , NF-kappa B , Camundongos , Animais , NF-kappa B/metabolismo , Interleucina-17 , Hemorragia Cerebral/metabolismo , Transdução de Sinais , Vesículas Extracelulares/metabolismoRESUMO
This publisher's note contains a correction to Opt. Lett.48, 6468 (2024)10.1364/OL.503007.
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Light-emitting diode (LED)-optical communication is a novel spectrum communication with wide field of view (FOV), light weight, and long-distance free-space capabilities. Due to atmospheric turbulence attenuation and pointing errors caused by long-distance communication, this Letter proposes a multi-pixel channel joint maximum likelihood (JML) reception method using a highly sensitive silicon photomultiplier (SiPM). To evaluate the performance of the SiPM under mobile terminal jittering communication, we analyze the effect of optical transmitting power, pointing errors, and signal-to-noise ratio (SNR) gain on optical communication by comparing JML with signal channel using the maximum likelihood (ML) algorithm. Both simulation analysis and experimental results demonstrate that the proposed JML algorithm to process signals received from SiPM multi-pixel channels can effectively mitigate the impact of pointing errors on the bit error rate (BER) of optical communications by two orders of magnitude at large jitter radians and SNR.
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BACKGROUND: Despite the known association between healthy lifestyles and reduced risk of breast cancer, it remains unclear whether systemic inflammation, as a consequence of unhealthy lifestyles, may mediate the association. METHODS: A cohort study of 259,435 female participants in the UK Biobank was conducted to estimate hazard ratio (HR) for breast cancer according to 9 inflammation markers using Cox regression models. We further estimated the percentage of total association between healthy lifestyle index (HLI) and breast cancer that is mediated by these inflammation markers. RESULTS: During 2,738,705 person-years of follow-up, 8,889 cases of breast cancer were diagnosed among 259,435 women in the UK Biobank cohort. Higher level of C-reactive protein (CRP), systemic immune-inflammation index (SII), CRP-to-albumin Ratio (CAR), CRP-to-lymphocyte Ratio (CLR), monocyte-to-HDL-c ratio (MHR), and neutrophil-to-HDL-c ratio (NHR) were associated with increased breast cancer risk, while a higher lymphocyte-to-monocyte ratio (LMR) was associated with a lower risk. The inverse association between HLI and breast cancer was weakly mediated by CRP (8.5%), SII (1.71%), CAR (8.66%), CLR (6.91%), MHR (6.27%), and NHR (7.33%). When considering individual lifestyle factors, CRP and CAR each mediated 16.58% and 17.20%, respectively, of the associations between diet score and breast cancer risk, while the proportion mediated for physical activity and breast cancer were 12.13% and 11.48%, respectively. Furthermore, MHR was found to mediate 13.84% and 12.01% of the associations between BMI, waist circumference, and breast cancer. CONCLUSION: The association of HLI and breast cancer is weakly mediated by the level of inflammation, particularly by CRP and CAR. Systemic inflammatory status may be an intermediate in the biological pathway of breast cancer development.
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Neoplasias da Mama , Humanos , Feminino , Neoplasias da Mama/epidemiologia , Neoplasias da Mama/etiologia , Estudos de Coortes , Análise de Mediação , Inflamação/complicações , Proteína C-Reativa/análise , Estilo de Vida SaudávelRESUMO
BACKGROUND: Dietary factors have consistently been associated with breast cancer risk. However, there is limited evidence regarding their associations in women with different genetic susceptibility to breast cancer, and their interaction with alcohol consumption is also not well understood. METHODS: We analyzed data from 261,853 female participants in the UK Biobank. Multivariable adjusted Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for associations between dietary factors and breast cancer risk. Additionally, we assessed the interaction of dietary factors with alcohol consumption and polygenic risk score (PRS) for breast cancer. RESULTS: A moderately higher risk of breast cancer was associated with the consumption of processed meat (HR = 1.10, 95% CI 1.03, 1.18, p-trend = 0.016). Higher intake of raw vegetables and fresh fruits, and adherence to a healthy dietary pattern were inversely associated with breast cancer risk [HR (95% CI):0.93 (0.88-0.99), 0.87 (0.81, 0.93) and 0.93 (0.86-1.00), p for trend: 0.025, < 0.001, and 0.041, respectively]. Furthermore, a borderline significant interaction was found between alcohol consumption and the intake of processed meat with regard to breast cancer risk (P for interaction = 0.065). No multiplicative interaction was observed between dietary factors and PRS. CONCLUSION: Processed meat was positively associated with breast cancer risk, and vegetables, fruits, and healthy dietary patterns were negatively associated with breast cancer risk. We found no strong interaction of dietary factors with alcohol consumption and genetic predisposition for risk of breast cancer.
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Neoplasias da Mama , Feminino , Humanos , Estudos de Coortes , Neoplasias da Mama/epidemiologia , Neoplasias da Mama/genética , Biobanco do Reino Unido , Bancos de Espécimes Biológicos , Fatores de Risco , Estudos Prospectivos , Dieta , Predisposição Genética para Doença , Modelos de Riscos ProporcionaisRESUMO
The use of metamaterials in the design of optics is an important strategy for controlling light fields. Numerous terahertz metamaterial devices have been recently designed; however, their performance is relatively limited. Here, the thermally induced phase change characteristics of vanadium dioxide (VO2) were harnessed to design a perfect wide-angle and ultra-wideband switchable terahertz absorber/reflector with a simple structure and three layers from top to bottom (VO2, SiO2, and Au). The absorption mechanism based on the impedance matching theory and electric field distribution was investigated, and the influence of structural parameters on the absorption rate and performance of the absorber in a wide wave vector range were analyzed. The study findings showed that the device perfectly absorbed a bandwidth of over 6.0 THz (absorption >90%). The absorption (reflection) was modulated from 0.01 to 0.999 with the change of the background temperature. More importantly, the device could switch between complete ultra-wideband reflection and perfect absorption over a wide angle range. This study provides important insights into the design of terahertz functional devices.
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The widespread existence of antibiotics in the environment has attracted growing concerns regarding the potential adverse effects on aquatic organisms, ecosystems, and human health even at low concentrations. Extensive efforts have been devoted to developing new methods for effective elimination of antibiotics from wastewater. Herein, a novel process of Fe2+ catalytically enhanced vacuum ultraviolet (VUV) irradiation was proposed as a promising approach for the removal of antibiotic trimethoprim (TMP) in water. Compared with UVC photolysis, VUV photolysis, and UVC/Fe2+, VUV/Fe2+ could increase the pseudo-first-order reaction rate constant of TMP removal by 6.6-38.4 times and the mineralization rate by 36.5%-59.9%. The excellent performance might originate from the synergistic effect of VUV and Fe2+, i.e., VUV irradiation could effectively split water and largely accelerate the Fe3+/Fe2+ cycle to generate more reactive oxygen species (ROS). EPR results indicated that â¢OH and O2â¢- were identified as the main ROS in the UVC/Fe2+ and VUV/Fe2+ processes, while â¢OH, O2â¢-, and 1O2 were involved in the VUV process. The operating parameters, such as Fe2+ dosage and initial TMP contents, were evaluated and optimized. Up to 8 aromatic intermediates derived from hydroxylation, demethylation, carbonylation, and methylene group cleavage were identified by UPLC-QTOF-MS/MS technique, the possible pathways of TMP degradation were proposed. Finally, the acute and chronic toxicity of intermediates formed during TMP degradation in the VUV/Fe2+ process were also evaluated.
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Fotólise , Trimetoprima , Raios Ultravioleta , Poluentes Químicos da Água , Trimetoprima/química , Trimetoprima/toxicidade , Poluentes Químicos da Água/química , Poluentes Químicos da Água/toxicidade , Cinética , Antibacterianos/química , Antibacterianos/toxicidade , Ferro/química , Vácuo , Catálise , AnimaisRESUMO
The electro-Fenton (EF) based on gas-diffusion electrodes (GDEs) reveals promising application prospective towards recalcitrant organics degradation because such GDEs often yields superior H2O2 generation efficiency and selectivity. However, the low efficiency of Fe2+/Fe3+ cycle with GDEs is always considered to be the limiting step for the EF process. In this study, activated carbon fiber (ACF) was firstly employed as co-catalyst to facilitate the performance of antibiotic cefaclor (CEC) decomposition in EF process. It was found that the addition of ACF co-catalyst achieved a rapid Fe2+/Fe3+ cycling, which significantly enhanced Fenton's reaction and hydroxyl radicals (â¢OH) generation. X-ray photoelectron spectroscopy (XPS) results indicated that the functional groups on ACF surface are related to the conversion of Fe3+ into Fe2+. Moreover, DMSO probing experiment confirmed the enhanced â¢OH production in EF + ACF system compared to conventional EF system. When inactive BDD and Ti4O7/Ti anodes were paired to EF system, the addition of ACF could significantly improve mineralization degree. However, a large amount of toxic byproducts, including chlorate (ClO3-) and perchlorate (ClO4-), were generated in these EF processes, especially for BDD anode, due to their robust oxidation capacity. Higher mineralization efficiency and less toxic ClO4- generation were obtained in the EF + ACF process with Ti4O7/Ti anode. This presents a novel alternative for efficient chloride-containing organic removal during wastewater remediation.
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Antibacterianos , Fibra de Carbono , Cefaclor , Eletrodos , Peróxido de Hidrogênio , Ferro , Poluentes Químicos da Água , Fibra de Carbono/química , Antibacterianos/química , Peróxido de Hidrogênio/química , Poluentes Químicos da Água/química , Ferro/química , Cefaclor/química , Catálise , Carvão Vegetal/química , Técnicas Eletroquímicas/métodosRESUMO
Autophagy is a cellular process that involves the fusion of autophagosomes and lysosomes to degrade damaged proteins or organelles. Triglycerides are hydrolyzed by autophagy, releasing fatty acids for energy through mitochondrial fatty acid oxidation (FAO). Inhibited mitochondrial FAO induces autophagy, establishing a crosstalk between lipid catabolism and autophagy. Peroxisome proliferator-activated receptor α (PPARα), a transcription factor, stimulates lipid catabolism genes, including fatty acid transport and mitochondrial FAO, while also inducing autophagy through transcriptional regulation of transcription factor EB (TFEB). Therefore, the study explores whether PPARα regulates autophagy through TFEB transcriptional control or mitochondrial FAO. In aquaculture, addressing liver lipid accumulation in fish is crucial. Investigating the link between lipid catabolism and autophagy is significant for devising lipid-lowering strategies and maintaining fish health. The present study investigated the impact of dietary fenofibrate and L-carnitine on autophagy by activating Pparα and enhancing FAO in Nile tilapia (Oreochromis niloticus), respectively. The dietary fenofibrate and L-carnitine reduced liver lipid content and enhanced ATP production, particularly fenofibrate. FAO enhancement by L-carnitine showed no changes in autophagic protein levels and autophagic flux. Moreover, fenofibrate-activated Pparα promoted the expression and nuclear translocation of Tfeb, upregulating autophagic initiation and lysosomal biogenesis genes. Pparα activation exhibited an increasing trend of LC3II protein at the basal autophagy and cumulative p62 protein trends after autophagy inhibition in zebrafish liver cells. These data show that Pparα activation-induced autophagic flux should be independent of lipid catabolism.
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Autofagia , Fenofibrato , Metabolismo dos Lipídeos , PPAR alfa , Animais , PPAR alfa/metabolismo , PPAR alfa/genética , Autofagia/efeitos dos fármacos , Metabolismo dos Lipídeos/efeitos dos fármacos , Fenofibrato/farmacologia , Carnitina/farmacologia , Fígado/metabolismo , Fígado/efeitos dos fármacos , Ciclídeos/metabolismo , Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/metabolismo , Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/genética , Ácidos Graxos/metabolismoRESUMO
Rechargeable aqueous batteries are promising energy storage devices because of their high safety and low cost. However, their energy densities are generally unsatisfactory due to the limited capacities of ion-inserted electrode materials, prohibiting their widespread applications. Herein, a high-energy aqueous all-sulfur battery was constructed via matching S/Cu2 S and S/CaSx redox couples. In such batteries, both cathodes and anodes undergo the conversion reaction between sulfur/metal sulfides redox couples, which display high specific capacities and rational electrode potential difference. Furthermore, during the charge/discharge process, the simultaneous redox of Cu2+ ion charge-carriers also takes place and contributes to a more two-electron transfer, which doubles the capacity of cathodes. As a result, the assembled aqueous all-sulfur batteries deliver a high discharge capacity of 447â mAh g-1 based on total mass of sulfur in cathode and anode at 0.1â A g-1 , contributing to an enhanced energy density of 393â Wh kg-1 . This work will widen the scope for the design of high-energy aqueous batteries.
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The energy densities of conventional aqueous batteries are often unsatisfactory due to the limited capacities of electrode materials.Therefore, the design of creative aqueous batteries has to be considered. Herein, aqueous S-MnO2 batteries are constructed by matching S/Cu2S redox couples and MnO2 deposition/dissolution. In such batteries, S/Cu2S redox couples undergo the solid-solid conversion reaction with four-electron transfer, ensuring a high specific capacity of 2220 mAh g-1 in S anodes.Furthermore, the conversion reaction of S/Cu2S redox couples can take place stably in acidic electrolyte that is essential for the MnO2 deposition/dissolution. As a result, the S/Cu2S redox couples can match MnO2 deposition/dissolution well, which endow the batteries with a membrane-free configuration. As a proof of concept, Ah-level prismatic and single-flow batteries were assembled and could operate stably for over 1000 h, demonstrating their great potential for large-scale energy storage. This work broadens the horizons of aqueous batteries beyond metal-manganese chemistry.
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Pseudomonas aeruginosa can form biofilms at the site of burn wound, leading to infection and the failure of treatment regimens. The previous in vitro study demonstrated that a combination of the quorum-quenching enzyme AidHA147G and the extracellular matrix hydrolase PslG was effective in inhibiting biofilm and promoting antibiotic synergy. The aim of the present study was to evaluate the efficacy of this combination of enzymes in conjunction with tobramycin in treating burn wound infected with P. aeruginosa. The results showed that this treatment was effective in quorum-quenching and biofilm inhibition on infected wounds. Compared with the tobramycin treatment only, simultaneous treatment with the enzymes and antibiotics significantly reduced the severity of tissue damage, decreased the bacterial load, and reduced the expression of the inflammatory indicators myeloperoxidase (MPO) and malondialdehyde (MDA). Topical application of the enzymes also reduced the bacterial load and inflammation to some extent. These results indicate that the combined-enzyme approach is a potentially effective treatment for P. aeruginosa biofilm infections of burn wounds.
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Queimaduras , Doenças Transmissíveis , Infecções por Pseudomonas , Infecção dos Ferimentos , Humanos , Antibacterianos/uso terapêutico , Antibacterianos/farmacologia , Pseudomonas aeruginosa , Infecções por Pseudomonas/tratamento farmacológico , Infecções por Pseudomonas/microbiologia , Tobramicina/farmacologia , Tobramicina/uso terapêutico , Biofilmes , Queimaduras/complicações , Queimaduras/tratamento farmacológico , Queimaduras/microbiologia , Infecção dos Ferimentos/microbiologiaRESUMO
BACKGROUND: Breastfeeding in infancy is associated with a lower risk of mortality among children, but the impact on mortality in middle and late adulthood remains unknown. OBJECTIVES: To assess the association between breastfeeding in infancy and mortality in middle and late adulthood. METHODS: We included 383,627 participants aged 40-73 from the UK Biobank (2006-2010) and followed up until 2021. Hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortality according to breastfeeding in infancy were estimated with Cox proportional hazards regression models. We further did a meta-analysis, including results from our present study and three other cohort studies (PROSPERO; number CRD42022348925). RESULTS: During a total of 4732,751 person-years of follow-up, 25,581 deaths were identified. Breastfeeding in infancy was associated with lower risks of mortality in middle and late adulthood, with adjusted HRs (95% CIs) of 0.95 (0.93-0.98) for all-cause mortality; 0.91 (0.87-0.96) for cardiovascular mortality and 0.94 (0.874-0.999) for respiratory mortality. Specifically, the association with mortality seemed to attenuate with age - stronger in middle-aged adults than in older adults. A similar association between breastfeeding in infancy and all-cause mortality was found in the meta-analysis. CONCLUSION: Breastfeeding in infancy is associated with a lower risk of mortality - even decades later - in middle and late adulthood.
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Aleitamento Materno , Doenças Cardiovasculares , Feminino , Pessoa de Meia-Idade , Criança , Humanos , Lactente , Idoso , Adulto , Estudos Prospectivos , Fatores de Risco , Estudos de Coortes , Modelos de Riscos ProporcionaisRESUMO
BACKGROUND: Early microbial exposure is associate with protective allergic asthma. We have previously demonstrated that Streptococcus pneumoniae aminopeptidase N (PepN), one of the pneumococcal components, inhibits ovalbumin (OVA) -induced airway inflammation in murine models of allergic asthma, but the underlying mechanism was incompletely determined. METHODS: BALB/c mice were pretreated with the PepN protein and exposed intranasally to HDM allergen. The anti-inflammatory mechanisms were investigated using depletion and adoptive transfer experiments as well as transcriptome analysis and isolated lung CD11chigh macrophages. RESULTS: We found pretreatment of mice with PepN promoted the proliferation of lung-resident F4/80+CD11chigh macrophages in situ but also mobilized bone marrow monocytes to infiltrate lung tissue that were then transformed into CD11high macrophages. PepN pre-programmed the macrophages during maturation to an anti-inflammatory phenotype by shaping the metabolic preference for oxidative phosphorylation (OXPHOS) and also inhibited the inflammatory response of macrophages by activating AMP-activated protein kinase. Furthermore, PepN treated macrophages also exhibited high-level costimulatory signaling molecules which directed the differentiation into Treg. CONCLUSION: Our results demonstrated that the expansion of CD11chigh macrophages in lungs and the OXPHOS metabolic bias of macrophages are associated with reduced allergic airway inflammation after PepN exposure, which paves the way for its application in preventing allergic asthma.
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Asma , Pneumonia , Camundongos , Animais , Streptococcus pneumoniae/metabolismo , Antígenos CD13 , Citocinas/metabolismo , Asma/metabolismo , Pulmão/metabolismo , Inflamação/prevenção & controle , Macrófagos/metabolismo , Anti-Inflamatórios , Fenótipo , Ovalbumina , Modelos Animais de Doenças , Camundongos Endogâmicos BALB CRESUMO
In the industrial environment, the positioning of mobile terminals plays an important role in production scheduling. Visible light positioning (VLP) based on a CMOS image sensor has been widely considered as a promising indoor positioning technology. However, the existing VLP technology still faces many challenges, such as modulation and decoding schemes, and strict synchronization requirements. In this paper, a visible light area recognition framework based on convolutional neural network (CNN) is proposed, where the training data is the LED images acquired by the image sensor. The mobile terminal positioning can be realized from the perspective of recognition without modulating LED. The experimental results show that the mean accuracy of the optimal CNN model is as high as 100% for the two-class and the four-class area recognitions, and is more than 95% for the eight-class area recognition. These results are obviously superior to other traditional recognition algorithms. More importantly, the model has high robustness and universality, which can be applied to various types of LED lights.
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There are various production items in the industrial internet of things (IIoT) environment, such as pedestrians, robots, automated automated guided vehicles, etc. The practice industrial environment requires simultaneous communication and sensing of production items to achieve intelligent production and control. Thus, sensing methods not only require the integration of communication but also achieve sensing tasks such as recognition and positioning. Compared with traditional sensing media, visible light sensing has the advantages of high-speed communication, high sensing accuracy, and security, low energy consumption, and has become a potential sensing technology. Based on the strong directivity of visible light spatial radiation and the consistency of light intensity and position, this paper proposes a multi-scale visible light sensing-region convolutional neural network (VLS-RCNN) framework based on shadow features for multiple target sensing. The framework enables the recognition and positioning to use shared visible light shadow features to assist each other, and the multi-scale compensation strategy of the shadow region makes the framework more robust. The simulation results show that positioning results in the sensing area improve the recognition accuracy. The recognition results also reduce the positioning error without additional overhead. Therefore, this paper provides a new perspective for the sensing technology in the future IIoT, which should be considered to sense objects of interest by utilizing the inherent characteristics of visible light.
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In the current visible light communication (VLC) system, a condenser lens is generally used in the front of receiver to achieve a higher data rate, making an extremely narrow field-of-view for the receiver. With the spread of Industrial Internet of Things (IIoT), the communication between mobile terminals is urgently required. A wide-range detecting method for VLC system in IIoT scenario is asked. In this paper, a novel self-adaptive wide-FoV receiver involving reconfigurable intelligent surfaces (RIS) is proposed. The effective detecting range of the receiver can be expanded by dynamically adjusting the incident light directions with the assistance of RIS. Based on the maximum arrived flux criterion, the mathematical model is established and the optimized RIS parameter tuning algorithm is presented. The feasibility and validity of the method are verified by simulation. The results show that the tolerable transceiver offset can be increased to 2â¼4 times as the conventional receiver.
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The industrial Internet of Things (IIoT) environment involves multiple production items, such as robots and automated guided vehicles (AGVs), among others. The practical industrial scenario requires communication of production items while also considering mobile recognition and positioning. Hence the perception approach requires not only combining communications but also realizing the recognition and positioning of multiple communication cells. This Letter proposes a multi-optical cell recognition and positioning framework based on LED image features. The LED images are obtained by a CMOS image sensor. This framework utilizes convolutional neural networks (CNN) to train LED images for recognition between multiple optical cells and locates precise positions through region recognition within the optical cells. The experimental results show that the mean accuracy of the CNN model for two LED cells is above 99%, and the mean accuracy of region recognition within the optical cell is as high as 100%, which is significantly better than other traditional recognition algorithms. Therefore, the proposed framework can provide location-aware services for visible light communication and has a wide application prospect in IIoT.