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Multi-mode multiplexing optical interconnection (MMOI) has been widely used as a new technology that can significantly expand communication bandwidth. However, the constant-on state of each channel in the existing MMOI systems leads to serious interference for receivers when extracting and processing information, necessitating introducing real-time selective-on function for each channel in MMOI systems. To achieve this goal, combining several practical requirements, we propose a real-time selective mode switch based on phase-change materials, which can individually tune the passing/blocking of different modes in the bus waveguide. We utilize our proposed particle swarm optimization algorithm with embedded neural network surrogate models (NN-in-PSO) to design this mode switch. The proposed NN-in-PSO significantly reduces the optimization cost, enabling multi-dimensional simultaneous optimization. The resulting mode switch offers several advantages, including ultra-compactness, rapid tuning, nonvolatility, and large extinction ratio. Then, we demonstrate the real-time channel selection function by integrating the mode switch into the MMOI system. Finally, we prove the fabricating robustness of the proposed mode switch, which paves the way for its large-scale application.
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Traditional optical information recognition (OIR), particle capture and manipulation require many optical devices or mechanical moving system components to achieve a specific function, which is difficult to achieve integration. This paper proposes a new method to realize these functions by using multi-focus metalens combining spectrum and polarization selection. The design incorporates three spectral bands, namely 500â nm, 580â nm, and 660â nm, within the visible light range. Additionally, it utilizes either left-handed or right-handed circularly polarized (LCP/RCP) light, resulting in six distinct focus focusing effects on a single focal plane. By analyzing the normalized light intensity (NLI) at the corresponding focus position, the OIR of any wavelength and polarization detection in the design can be realized, and the particle capture at different focusing positions can be realized. Our work can provide a new idea for the high integration of on-chip light recognition and operation and inspire the design of a highly integrated optical system with a smaller size and more substantial function.
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In this paper, a 1 × 2 photonic switch is designed based on a silicon-on-insulator (SOI) platform combined with the phase change material (PCM), Sb2S3, assisted by the direct binary search (DBS) algorithm. The designed photonic switch exhibits an impressive operating bandwidth ranging from 1450 to 1650 nm. The device has an insertion loss (IL) from 0.44 dB to 0.70 dB (of less than 0.7 dB) and cross talk (CT) from -26 dB to -20 dB (of less than -20 dB) over an operating bandwidth of 200 nm, especially an IL of 0.52 dB and CT of -24 dB at 1550 nm. Notably, the device is highly compact, with footprints of merely 3 × 4 µm2. Furthermore, we have extended the device's functionality for multifunctional operation in the C-band that can serve as both a 1 × 2 photonic switch and a 3 dB photonic power splitter. In the photonic switch mode, the device demonstrates an IL of 0.7 dB and a CT of -13.5 dB. In addition, when operating as a 3 dB photonic power splitter, the IL is less than 0.5 dB.
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Propofol has been found to have a protective effect against spinal cord injury (SCI). However, the underlying molecular mechanism of propofol regulating SCI process remains unclear. In this study, lipopolysaccharide (LPS)-induced PC12 cells were used to build SCI cell models. Cell viability and apoptosis were determined by cell counting kit 8 assay, flow cytometry, and caspase-3 activity detection. The protein levels of apoptosis-related markers and TNFAIP3 interacting protein 2 (TNIP2) were assessed using western blot analysis, and the levels of inflammatory factors were detected using ELISA. Cell oxidative stress was evaluated by measuring malondialdehyde (MDA) and reactive oxygen species (ROS) levels. The expression of microRNA (miR)-672-3p was examined by quantitative real-time PCR. SCI rat models were constructed to assess the effect of propofol in vivo. We found that propofol treatment promoted viability, while inhibited apoptosis, inflammation and oxidative stress of LPS-induced PC12 cells. Propofol decreased miR-672-3p expression, and miR-672-3p overexpression eliminated the inhibiting effect of propofol on LPS-induced PC12 cell injury. Besides, miR-672-3p targeted TNIP2, and TNIP2 knockdown reversed the protective effect of miR-672-3p inhibitor or propofol against LPS-induced PC12 cell injury. In vivo experiments, propofol treatment enhanced the motor function recovery and inhibited apoptosis of SCI rat models. In conclusion, propofol increased TNIP2 level by reducing miR-672-3p expression, thereby alleviating LPS-induced PC12 cell injury and improving the motor function of SCI rat models.
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CONTEXT: Shenxiang Suhe pill (SXSH), a traditional Chinese medicine, is clinically effective against coronary heart disease, but the mechanism of cardiac-protective function is unclear. OBJECTIVE: We investigated the cardiac-protective mechanism of SXSH via modulating gut microbiota and metabolite profiles. MATERIALS AND METHODS: Sprague-Dawley (SD) male rats were randomly divided into 6 groups (n = 8): Sham, Model, SXSH (Low, 0.063 g/kg; Medium, 0.126 g/kg; High, 0.252 g/kg), and Ato (atorvastatin, 20 mg/kg). Besides the Sham group, rats were modelled with acute myocardial infarction (AMI) by ligating the anterior descending branch of the left coronary artery (LAD). After 3, 7, 14 days' administration, ultrasound, H&E staining, serum enzymic assay, 16S rRNA sequencing were conducted to investigate the SXSH efficacy. Afterwards, five groups of rats: Sham, Model, Model-ABX (AMI with antibiotics-feeding), SXSH (0.126 g/kg), SXSH-ABX were administrated for 14 days to evaluate the gut microbiota-dependent SXSH efficacy, and serum untargeted metabolomics test was performed. RESULTS: 0.126 g/kg of SXSH intervention for 14 days increased ejection fraction (EF, 78.22%), fractional shortening (FS, 109.07%), and aortic valve flow velocities (AV, 21.62%), reduced lesion area, and decreased serum LDH (8.49%) and CK-MB (10.79%). Meanwhile, SXSH upregulated the abundance of Muribaculaceae (199.71%), Allobaculum (1744.09%), and downregulated Lactobacillus (65.51%). The cardiac-protective effect of SXSH was disrupted by antibiotics administration. SXSH altered serum metabolites levels, such as downregulation of 2-n-tetrahydrothiophenecarboxylic acid (THTC, 1.73%), and lysophosphatidylcholine (lysoPC, 4.61%). DISCUSSION AND CONCLUSION: The cardiac-protective effect and suggested mechanism of SXSH could provide a theoretical basis for expanding its application in clinic.
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Microbioma Gastrointestinal , Infarto do Miocárdio , Ratos , Masculino , Animais , Ratos Sprague-Dawley , RNA Ribossômico 16S , Infarto do Miocárdio/tratamento farmacológico , Infarto do Miocárdio/metabolismo , Antibacterianos/farmacologiaRESUMO
Metalens with extended depth of focus (EDOF) can extend the mapping area of the image, which leads to novel applications in imaging and microscopy. Since there are still some disadvantages for existing EDOF metalenses based on forward design, such as asymmetric point spread function (PSF) and non-uniformly distributed focal spot, which impair the quality of images, we propose a double-process genetic algorithm (DPGA) optimization to inversely design the EDOF metalens for addressing these drawbacks. By separately adopting different mutation operators in successive two genetic algorithm (GA) processes, DPGA exhibits significant advantages in searching for the ideal solution in the whole parameter space. Here, the 1D and 2D EDOF metalenses operating at 980â nm are separately designed via this method, and both of them exhibit significant depth of focus (DOF) improvement to that of conventional focusing. Furthermore, a uniformly distributed focal spot can be maintained well, which can guarantee stable imaging quality along the longitudinal direction. The proposed EDOF metalenses have considerable potential applications in biological microscopy and imaging, and the scheme of DPGA can be promoted to the inverse design of other nanophotonics devices.
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In this work, we use the inverse design method to design three-channel and four-channel dual-mode waveguide crossings with the design regions of 4.32 µm-wide regular hexagon and 6.68 µm-wide regular octagon, respectively. Based on the highly-symmetric structures, the fundamental transverse electric (TE0) and TE1 modes propagate through the waveguide crossings efficiently. Moreover, the devices are practically fabricated and experimentally characterized. The measured insertion losses and crosstalks of the three-channel and dual-mode waveguide crossing for both the TE0 and TE1 modes are less than 1.8â dB and lower than -18.4â dB from 1540â nm to 1560â nm, respectively. The measured insertion losses of the four-channel and dual-mode waveguide crossing for the TE0 and TE1 modes are less than 1.8â dB and 2.5â dB from 1540â nm to 1560â nm, respectively, and the measured crosstalks are lower than -17.0â dB. In principle, our proposed scheme can be extended to waveguide crossing with more channels and modes.
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In recent years, structural color has developed rapidly due to its distinct advantages, such as low loss, high spatial resolution and environmental friendliness. Various inverse design methods have been extensively investigated to efficiently design optical structures. However, the optimization method for the inverse design of structural color remains a formidable challenge. Traditional optimization approaches, such as genetic algorithms require time-consuming repetitions of structural simulations. Deep learning-assisted design necessitates prior simulations and large amounts of data, making it less efficient for systems with a small number of features. This study proposes a tensor completion algorithm capable of swiftly and accurately predicting missing datasets based on partially obtained datasets to assist in structural color design. Transforming the complex physical problem of structural color design into a spatial structure relationship problem linking geometric parameters and spectral data. The method utilizes tensor multilinear data analysis to effectively capture the complex relationships associated with geometric parameters and spectral data in higher-order data. Numerical and experimental results demonstrate that the algorithm exhibits high reliability in terms of speed and accuracy for diverse structures, datasets of varying sizes, and different materials, significantly enhancing design efficiency. The proposed algorithm offers a viable solution for inverse design problems involving complex physical systems, thereby introducing a novel approach to the design of photonic devices. Additionally, numerical experiments illustrate that the structural color of cruciform resonators with diamond can overcome the high loss issues observed in traditional dielectric materials within the blue wavelength region and enhance the corrosion resistance of the structure. We achieve a wide color gamut and a high-narrow reflection spectrum nearing 1 by this structure, and the theoretical analysis further verifies that diamond holds great promise in the realm of optics.
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Blindly increasing the channels of the mode (de)multiplexer on the single-layer chip can cause the device structure to be too complex to optimize. The three-dimensional (3D) mode division multiplexing (MDM) technology is a potential solution to extend the data capacity of the photonic integrated circuit by assembling the simple devices in the 3D space. In our work, we propose a 16 × 16 3D MDM system with a compact footprint of about 100â µm × 5.0â µm × 3.7â µm. It can realize 256 mode routes by converting the fundamental transverse electric (TE0) modes in arbitrary input waveguides into the expected modes in arbitrary output waveguides. To illustrate its mode-routing principle, the TE0 mode is launched in one of the sixteen input waveguides, and converted into corresponding modes in four output waveguides. The simulated results indicate that the ILs and CTs of the 16 × 16 3D MDM system are less than 3.5â dB and lower than -14.2â dB at 1550â nm, respectively. In principle, the 3D design architecture can be scaled to realize arbitrary network complexity levels.
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With the development of camouflage technology, single camouflage technology can no longer adapt to existing environments, and multispectral camouflage has attracted much research focus. However, achieving camouflage compatibility across different bands remains challenging. This study proposes a multispectral camouflage metamaterial structure using a particle swarm optimization algorithm, which exhibits multifunctional compatibility in the visible and infrared bands. In the visible band, the light absorption rate of the metamaterial structure exceeds 90%. In addition, color camouflage can be achieved by modifying the top cylindrical nanostructure to display different colors. In the infrared band, the metamaterial structure can achieve three functions: dual-band infrared camouflage (3-5 µm and 8-14 µm), laser stealth (1.06, 1.55, and 10.6 µm), and heat dissipation (5-8 µm). This structure exhibits lower emissivity in both the 3-5-µm (É=0.18) and 8-14-µm (É=0.27) bands, effectively reducing the emissivity in the atmospheric window band. The structure has an absorption rate of 99.7%, 95.5%, and 95% for 1.06, 1.55, and 10.6 µm laser wavelengths, respectively. Owing to its high absorptivity, laser stealth is achieved. Simultaneously, considering the heat dissipation requirements of metamaterial structures, the structural emissivity is 0.7 in the non-atmospheric window (5-8 µm), and the heat can be dissipated through air convection. Therefore, the designed metamaterial structure can be used in military camouflage and industrial applications.
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In this work, we design, fabricate, and characterize a different-mode (waveguide-connected) power splitter ((W)PS) by what we believe to be a novel multi-dimension direct-binary-search algorithm that can significantly balance the device performance, time cost, and fabrication robustness by searching the state-dimension, rotation-dimension, shape-dimension, and size-dimension parameters. The (W)PS can simultaneously generate the fundamental transverse electric (TE0) and TE1 mode with the 1:1 output balance. Compared with the PS, the WPS can greatly shorten the adiabatic taper length between the single-mode waveguide and the grating coupler. The measured results of the different-mode (W)PS indicate that the insertion loss and crosstalk are less than 0.9 (1.3) dB and lower than -17.8 (-14.9) dB from 1540â nm to 1560â nm. In addition, based on the tunable tap couplers, the different-mode (W)PS can be extended to multiple output ports with different modes and different transmittances.
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In this work, we investigate polarization-insensitive dual bound states in the continuum (BICs) at Γ point in symmetric photonic crystal (PhC) slabs. Especially, BICs are tailored by tuning intra- and intercellular optical coupling strengths of PhC slabs. Based on four different approaches, we realize the transition from BIC to quasi-BIC resonances with various dispersion behaviors while maintaining the symmetry of slabs. Also, we show the two resonances are lowest-order even and odd eigenmodes that can match the symmetry of the incident plane wave, and their quality (Q) factors follow the inverse quadratic law except for cases with larger perturbations. Furthermore, multipolar decomposition reveals that even quasi-BICs are dominated by the toroidal dipole and magnetic quadrupole, while odd quasi-BICs are governed by the magnetic dipole and electric quadrupole. Interestingly, an anomalous increase of the Q factor is observed in one case, which is attributed to the mode transformation. Finally, anisotropic coupling adjustment is discussed, which enriches the degrees of freedom to manipulate BICs. This work introduces a novel perspective to tailor BICs at Γ point in PhC slabs and has potential planar photonic applications for nonlinear enhancement and sensing.
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Anisotropic metameterials (AM) provide a new avenue for a next-generation silicon platform to design ultra-compact, densely integrated optical components, thus functional devices based on AM are drawing increasing attention recently. Here, we propose a novel efficient polarization beam splitter (PBS) with high polarization extinction ratio based on AM. An ultra-compact coupling region of 2.5 × 14 µm2 is achieved by tailoring the AM structures, which can efficiently suppress the TE mode coupling, and enhance the TM mode coupling in the directional couplers simultaneously. The insertion loss is simulated to be as low as <0.2 dB within a bandwidth of 70 nm for both modes, and the polarization extinction ratio is as high as 46 dB and 33 dB for TE and TM modes, respectively. We also experimentally demonstrate the proposed PBS, with low insertion loss of 1 dB , high extinction ratio of >20 dB and wide operational bandwidth of >80 nm.
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Infrared (IR) stealth with thermal management is highly desirable in military applications and astronomy. However, developing selective IR emitters with properties suitable for IR stealth and thermal management is challenging. In this study, we present the theoretical framework for a selective emitter based on an inverse-designed metasurface for IR stealth with thermal management. The emitter comprises an inverse-designed gold grating, a Ge2Sb2Te5 (GST) dielectric layer, and a gold reflective layer. The hat-like function, which describes an ideal thermal selective emitter, is involved in the inverse design algorithm. The emitter exhibits high performance in IR stealth with thermal management, with the low emissivity (É3-5 µm =0.17; É8-14 µm =0.16) for dual-band atmospheric transmission windows and high emissivity (É5-8 µm =0.85) for non-atmospheric windows. Moreover, the proposed selective emitter can realize tunable control of thermal radiation in the wavelength range of 3-14 µm by changing the crystallization fraction of GST. In addition, the polarization-insensitive structure supports strong selective emission at large angles (60°). Thus, the selective emitter has potential for IR stealth, thermal imaging, and mid-infrared multifunctional equipment.
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In this Letter, we propose collective topological corner modes in all-dielectric photonic crystal (PhC) supercell arrays, where each supercell is a second-order topological insulator. We show that coupled multipole corner modes are embedded in surrounding bulk modes at the Γ point even without the band gap, and individual or superposed dipole corner modes are selectively excited with collective behaviors by incident plane waves. These collective modes possess high-quality factors with an optimized thickness of the slab, and multipole decomposition reveals they are dominated by toroidal dipole and magnetic quadrupoles. Finally, we shrink the nontrivial region in each supercell to one unit-cell limit, where we show that collective corner modes still exist. Potential large-area topological applications are also discussed.
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Waveguide taper, a key component in the photonic integrated circuit (PIC), enables on-chip mode conversion, but large-footprint tapers are detrimental to the PIC, which desires compact and efficient devices. Polarization sensitivity also limits the tapers in the applications involving orthogonal modes. In this work, we design an efficient polarization-insensitive ultra-short MMI-based waveguide taper, through the mode spreading principle and the self-image principle. The proposed taper is 26.3 µm long, one order of magnitude shorter than the standard linear taper. We fabricate the taper, and experimentally demonstrate that it exhibits a high transmission efficiency of â¼70% and a wide 1 dB bandwidth of >54nm, for both TE and TM polarizations.
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In this paper, we propose a graphene-based metasurface that exhibits multifunctions including tunable filter and slow-light which result from surface plasmon polaritons (SPPs) of graphene and plasmon induced transparency (PIT), respectively. The proposed metasurface is composed by two pairs of graphene nano-rings and a graphene nanoribbon. Each group of graphene rings is separately placed on both sides of the graphene nanoribbon. Adjusting the working state of the nanoribbon can realize the functional conversion of the proposed multifunctional metasurface. After that, in the state of two narrow filters, we put forward the application concept of dual-channel optical switch. Using phase modulation of PIT and flexible Fermi level of graphene, we can achieve tunable slow light. In addition, the result shows that the graphene-based metasurface as a refractive index sensor can achieve a sensitivity of 13670 nm/RIU in terahertz range. These results enable the proposed device to be widely applied in tunable optical switches, slow light, and sensors.
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Metasurfaces, the two-dimensional artificial metamaterials, have attracted intensive attention due to their abnormal ability to manipulate the electromagnetic wave. Although there have been considerable efforts to design and fabricate beam steering devices, continuously tunable devices with a uniform bias-voltage have not been achieved. Finding new ways to realize more convenient and simpler wavefront modulation of light still requires research efforts. In this article, a series of novel reflective metasurfaces are proposed to continuously modulate the wavefront of terahertz light by uniformly adjusting the bias-voltage. By introducing the innovation of nonuniform periodic structures, we realize the gradient distribution of the reflected light phase-changing-rate which is the velocity of phase changing with Fermi energy. Based on strict phase distribution design scheme, a beam scanner and a variable-focus reflective metalens are both demonstrated successfully. Furthermore, dynamic and continuous control of either the beam azimuth of beam scanner or the focal length of metalens can be achieved by uniformly tuning the Fermi energy of graphene. Our work provides a potentially efficient method for the development and simplification of the adjustable wavefront controlling devices.
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We propose a tunable multilayer-graphene-based broadband metamaterial selective absorber using the finite-difference time domain. The simulation results reveal that the absorption spectra of the proposed metamaterial with the nano-cylinder and 30-layer graphene show high absorption (88.3%) in the range of 250-2300 nm, which covers the entire solar spectrum. Moreover, the graphene-based metamaterial has a low thermal emittance of 3.3% in the mid-infrared range (4-13 µm), which can greatly reduce the heat loss. The proposed metamaterial has a tunable cutoff wavelength, which can be tuned by controlling the Fermi level of graphene. In addition, our structure is an angle-insensitive absorber, and the device has the potential to be widely used in solar cell and thermal detectors.
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We numerically study a dielectric coupled guided-mode resonant (GMR) system, which includes two silicon (Si) grating waveguide layers (GWLs) stacked on CaF2 substrates. It is confirmed that the coupling between the top and bottom GMR modes starts once a Fabry-Perot (F-P) resonator is introduced, and electromagnetically induced transparency (EIT)-like spectral responses occur in the coupled GMR systems. A very narrow transparency window with a high-quality (Q) factor EIT-like effect of up to 288,892 was demonstrated. Furthermore, EIT-like response wavelengths can be flexibly designed in wide wavelength range by modifying either the GMR resonance frequencies or the space between two GWLs. Therefore, this EIT-like response in coupled GMR systems would pave the way towards novel sensors with extremely high sensitivity.