High-flow nasal cannula oxygen therapy for mild-moderate acute respiratory failure in patients with blunt chest trauma: An exploratory descriptive study.

OBJECTIVE: The use of high-flow nasal cannula (HFNC) oxygen therapy is gaining popularity for the treatment of acute respiratory failure (ARF). However, limited evidence exists regarding the effectiveness of HFNC for hypoxemic ARF in patients with blunt chest trauma (BCT). METHODS: This retrospective analysis focused on BCT patients with mild-moderate hypoxemic ARF who were treated with either HFNC or non-invasive ventilation (NIV) in the emergency medicine department from January 2021 to December 2022. The primary endpoint was treatment failure, defined as either invasive ventilation, or a switch to the other study treatment (NIV for patients in the NFNC group, and vice-versa). RESULTS: A total of 157 patients with BCT (72 in the HFNC group and 85 in the NIV group) were included in this study. The treatment failure rate in the HFNC group was 11.1% and 16.5% in the NIV group - risk difference of 5.36% (95% CI, -5.94-16.10%; P = 0.366). The most common cause of failure in the HFNC group was aggravation of respiratory distress. While in the NIV group, the most common reason for failure was treatment intolerance. Treatment intolerance in the HFNC group was significantly lower than that in the NIV group (1.4% vs 9.4%, 95% CI 0.40-16.18; P = 0.039). Univariate logistic regression analysis showed that chronic respiratory disease, abbreviated injury scale score (chest) (≥3), Acute Physiology and Chronic Health Evaluation II score (≥15), partial arterial oxygen tension /fraction of inspired oxygen (≤200) at 1 h of treatment and respiratory rate (≥32 /min) at 1 h of treatment were risk factors associated with HFNC failure. CONCLUSION: In BCT patients with mild-moderate hypoxemic ARF, the usage of HFNC did not lead to higher rate of treatment failure when compared to NIV. HFNC was found to offer better comfort and tolerance than NIV, suggesting it may be a promising new respiratory support therapy for BCT patients with mild-moderate ARF.

TfOH-Catalyzed Phosphinylation of 2,3-Allenols into γ-Ketophosphine Oxides.

The first facile and efficient acid-catalyzed direct coupling of a wide range of unprotected 2,3-allenols with arylphosphine oxides was developed, offering a general, one-step approach for the synthesis of structurally diverse γ-ketophosphine oxides accompanied by concurrent C-P/C═O bond formation with remarkable functional group tolerance and complete atom-economy under metal- and additive-free conditions. Mechanistic studies showed that this transformation involved a rearrangement and a phospha-Michael reaction.

Furan formation from ingredient interactions and furan mitigation by sugar alcohols and antioxidants of bamboo leaves in milk beverage model systems.

BACKGROUND: Furan is a potential carcinogen that can be formed in various heat-treated foods, including milk beverages. Studies on the formation and mitigation of furan in milk beverages are rare. In the present study, the effects of ingredients on furan formation and the reduction of furan by sugar alcohols and antioxidants of bamboo leaves (AOB) were investigated in a milk beverage model system. RESULTS: The results obtained demonstrated that the Maillard reaction is the major pathway for furan formation in a milk beverage model system, and the type of sugar has a great influence on furan formation. High fructose corn syrup (HFCS 55) was more favorable for furan formation than sucrose. Thermal oxidation of ascorbic acid and lipids significantly enhanced furan generation. Xylitol, sorbitol and mannitol inhibited furan formation in model systems by replacing sucrose or HFCS. The maximum inhibition percentage of furan formation was observed when sucrose/HFCS was substituted completely by xylitol and the inhibition rate was 78.28% and 88.64% separately for the sucrose/HFCS-containing system. AOB significantly inhibited furan formation and the inhibition rate reached 32.13% and 28.52% separately for the sucrose/HFCS-containing system. CONCLUSION: The present study demonstrates that the use of sugar alcohols and AOB could be a feasible way of reducing furan formation in thermally processed milk beverages. © 2019 Society of Chemical Industry.

The effect of lactulose thermal degradation products on ß-lactoglobulin: Linear-, loop-, and cross-link structural modifications and reduced digestibility.

The thermal degradation products of lactulose and the interaction between lactulose and ß-lactoglobulin (ßLg) were investigated in a thermal model system. Lactulose was thermally degraded into fructose and galactose, which were further degraded into methylglyoxal, glyoxal, 3-deoxyglucosone, and 2, 3-butanedione via heating. After incubating with lactulose, the structure of ßLg was changed, which manifested by the formation of new band with doubled the molecular weight of ßLg in the mobility spectrum and the changes in the internal fluorescence spectrum. Furthermore, the lysine and arginine residues of ßLg were confirmed to be the modification sites of the thermal degradation products of lactulose, and the modification types of linear-, loop-, and cross-linked were detected. The digestibility of ßLg incubated with lactulose was significantly decreased due to the modification of trypsin digestion sites and the formation of cross-linked conjunctions. Therefore, the adverse effects of lactulose application in thermally processed foods should be concerned.

Research on the Combination of Firefly Intelligent Algorithm and Asphalt Material Modulus Back Calculation.

The modulus of asphalt pavement material is a necessary parameter for the design, strength measuring and stability evaluation of asphalt pavement. To get more precise test data for asphalt pavement material modulus, a new modulus back calculation method is proposed in this article, named as the Firefly Asphalt Back Calculation Method (FABCM). This novel method uses the firefly optimization algorithm, which is a kind of particle swarm intelligence algorithm imitating the information transfer process among fireflies. To demonstrate the reliability and stability of FABCM, and to study the feasibility of multi-parameter modulus back calculation methods, this article used theoretical deflection curves calculated by BISAR3.0 and the actual measurement data of deflection curves and vertical pressures on the subgrade top surfaces on the full-scale test circular track in the Research Institute of Highway, Ministry of Transport (RIOHTrack) to conduct a modulus back calculation. The results show that FABCM only takes 0.5-1 s for each calculation, and the back calculation errors in the verification of FABCM are mostly smaller than 1%, which means that the firefly optimization algorithm was modified effectively in this article. Moreover, this article also indicates some key factors influencing the accuracy of modulus back calculation, and several reasonable suggestions to the application of modulus back calculation.

Investigation of Adhesion Properties of Tire-Asphalt Pavement Interface Considering Hydrodynamic Lubrication Action of Water Film on Road Surface.

To obtain the tire−pavement peak adhesion coefficient under different road states, a field measurement and FE simulation were combined to analyze the tire−pavement adhesion characteristics in this study. According to the identified texture information, the power spectral distribution of the road surface was obtained using the MATLAB Program, and a novel tire hydroplaning FE model coupled with a textured pavement model was established in ABAQUS. Experimental results show that here exists an "anti-skid noncontribution area" for the insulation and lubrication of the water film. Driving at the limit speed of 120 km/h, the critical water film thickness for the three typical asphalt pavements during hydroplaning was as follows: AC pavement, 0.56 mm; SMA pavement, 0.76 mm; OGFC pavement, 1.5 mm. The road state could be divided into four parts dry state, wet sate, lubricated state, and ponding state. Under the dry road state, when the slip rate was around 15%, the adhesion coefficient reached the peak value, i.e., around 11.5% for the wet road state. The peak adhesion coefficient for the different asphalt pavements was in the order OGFC > SMA > AC. This study can provide a theoretical reference for explaining the tire−pavement interactions and improving vehicle brake system performance.

Oxyberberine Prevented Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Mitophagy.

Acute lung injury (ALI) is a serious respiratory syndrome characterized with uncontrolled inflammatory response. Oxyberberine has strong potential for clinical usage since it showed strong anti-inflammatory, antifungal, and antiarrhythmic effects in various diseases. In the present study, we evaluated whether oxyberberine can inhibit lipopolysaccharide- (LPS-) induced ALI in vivo and further evaluated the possible involvement of mitophagy in vitro by using A549 cells, a human lung epithelial cell line. Our in vivo study shows that oxyberberine significantly inhibited LPS-induced lung pathological injury and lung edema, as indicated by the changes in lung wet/dry ratio and total protein levels in the BALF in mice. Moreover, oxyberberine inhibited inflammation, as indicated by the changes of neutrophil accumulation and production of proinflammatory cytokines including tumor necrosis factor α (TNF-α), interleukin 1ß (IL-1ß), and IL-6 in both the lung and bronchoalveolar lavage fluid (BALF) in ALI mice. Our in vitro study shows that LPS significantly decreased the protein level of mitochondrial proteins, including cytochrome c oxidase subunit IV (COX IV), p62, and mitofusin-2 (Mfn2) in A549 cells. In addition, LPS induced significant Parkin1 translocation from cytoplasm to mitochondria. These changes were significantly inhibited by oxyberberine. Notably, the inhibitory effect of oxyberberine was almost totally lost in the presence of lysosome fusion inhibitor bafilomycin A1 (Baf), a mitophagy inhibitor. In conclusion, the present study demonstrated that oxyberberine alleviated LPS-induced inflammation in ALI via inhibition of Parkin-mediated mitophagy.

Palladium-catalyzed C-P cross-coupling of allenic alcohols with H-phosphonates leading to 2-phosphinoyl-1,3-butadienes.

The first facile, efficient, atom-economical and regioselective palladium-catalyzed direct C-P cross-coupling of unprotected allenic alcohols with H-phosphonates for the one-pot synthesis of structurally diverse multisubstituted 2-phosphinoyl-1,3-butadienes was developed. This strategy would enrich the allene chemistry and afford new scaffolds to construct complex molecular skeletons.