Clinical efficacy of total laparoscopic splenectomy for portal hypertension and its influence on hepatic hemodynamics and liver function.

BACKGROUND: The liver hemodynamic changes caused by portal hypertension (PH) are closely related to various complications such as gastroesophageal varices and portosys-temic shunts, which may lead to adverse clinical outcomes in these patients, so it is of great clinical significance to find treatment strategies with favorable clinical efficacy and low risk of complications. AIM: To study the clinical efficacy of total laparoscopic splenectomy (TLS) for PH and its influence on hepatic hemodynamics and liver function. METHODS: Among the 199 PH patients selected from October 2016 to October 2020, 100 patients [observation group (OG)] were treated with TLS, while the remaining 99 [reference group (RG)] were treated with open splenectomy (OS). We observed and compared the clinical efficacy, operation indexes [operative time (OT) and intraoperative bleeding volume], safety (intraperitoneal hemorrhage, ascitic fluid infection, eating disorders, liver insufficiency, and perioperative death), hepatic hemodynamics (diameter, velocity, and flow volume of the portal vein system), and liver function [serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), and serum total bilirubin (TBil)] of the two groups. RESULTS: The OT was significantly longer and intraoperative bleeding volume was significantly lesser in the OG than in the RG. Additionally, the overall response rate, postoperative complications rate, and liver function indexes (ALT, AST, and TBil) did not differ significantly between the OG and RG. The hepatic hemodynamics statistics showed that the pre- and postoperative blood vessel diameters in the two cohorts did not differ statistically. Although the postoperative blood velocity and flow volume reduced significantly when compared with the preoperative values, there were no significant inter-group differences. CONCLUSION: TLS contributes to comparable clinical efficacy, safety, hepatic hemodynamics, and liver function as those of OS in treating PH, with a longer OT but lesser intraoperative blood loss.

Transcriptional progressive patterns from mild to severe renal ischemia/reperfusion-induced kidney injury in mice.

The renal ischemia/reperfusion (I/R)-induced acute kidney injury incidence after nephron-sparing surgery for localized renal tumors is 20%, but the biological determinant process of postoperative acute kidney injury remains unclear. Using Gene Expression Omnibus database (GSE192883) and several bioinformatics analyses (discrete time points analysis, gene set enrichment analysis, dynamic network biomarker analysis, etc), combined with the establishment of the I/R model for verification, we identified three progressive patterns involving five core pathways confirmed using gene set enrichment analysis and six key genes (S100a10, Pcna, Abat, Kmo, Acadm, and Adhfe1) verified using quantitative polymerase chain reaction The dynamic network biomarker (DNB) subnetwork composite index value is the highest in the 22-min ischemia group, suggesting the transcriptome expression level fluctuated sharply in this group, which means 22-min ischemia is an critical warning point. This study illustrates the core molecular progressive patterns from mild to severe I/R kidney injury, laying the foundation for precautionary biomarkers and molecular intervention targets for exploration. In addition, the safe renal artery blocking time of nephron-sparing surgery that we currently accept may not be safe anymore.

Corrigendum: Transcriptional progressive patterns from mild to severe renal ischemia/reperfusion-induced kidney injury in mice.

[This corrects the article DOI: 10.3389/fgene.2022.874189.].

Protected quantum coherence by gain and loss in a noisy quantum kicked rotor.

We study the effects of non-Hermiticity on quantum coherence via a noisy quantum kicked rotor (NQKR). The random noise comes from the fluctuations in kick amplitude at each time. The non-Hermitian driving indicates the imaginary kicking potential, representing the environment-induced atom gain and loss. In the absence of gain and loss, the random noise destroys quantum coherence manifesting dynamical localization, which leads to classical diffusion. Interestingly, in the presence of non-Hermitian kicking potential, the occurrence of dynamical localization is highly sensitive to the gain and loss, manifesting the restoration of quantum coherence. Using the inverse participation ratio arguments, we numerically obtain a phase diagram of the classical diffusion and dynamical localization on the parameter plane of noise amplitude and non-Hermitian driving strength. With the help of analysis on the corresponding quasieigenstates, we achieve insight into dynamical localization, and uncover that the origin of the localization is interference between multiple quasi-eigenstates of the quantum kicked rotor. We further propose an experimental scheme to realize the NQKR in a dissipative cold atomic gas, which paves the way for future experimental investigation of an NQKR and its anomalous non-Hermitian properties.

Chaotic dynamics of a non-Hermitian kicked particle.

We investigate both the classical and quantum dynamics of a kicked particle withPTsymmetry. In chaotic situation, the mean energy of the real parts of momentum linearly increases with time, and that of the imaginary momentum exponentially increases. There exists a breakdown time for chaotic diffusion, which is obtained both analytically and numerically. The quantum diffusion of this non-Hermitian system follows the classically chaotic diffusion of Hermitian case during the Ehrenfest time, after which it is completely suppressed. Interestingly, the Ehrenfest time decreases with the decrease of effective Planck constant or the increase of the strength of the non-Hermitian kicking potential. The exponential growth of the quantum out-of-time-order correlators (OTOC) during the initially short time interval characterizes the feature of the exponential diffusion of imaginary trajectories. The long time behavior of OTOC reflects the dynamical localization of quantum diffusion. The dynamical behavior of inverse participation ratio can quantify thePTsymmetry breaking, for which the rule of the phase transition points is numerically obtained.

Directed momentum current induced by the PT-symmetric driving.

We investigate the directed momentum current in the quantum kicked rotor model with PT-symmetric deriving potential. For the quantum nonresonance case, the values of quasienergy become complex when the strength of the imaginary part of the kicking potential exceeds a threshold value, which demonstrates the appearance of the spontaneous PT symmetry breaking. In the vicinity of the transition point, the momentum current exhibits a staircase growth with time. Each platform of the momentum current corresponds to the mean momentum of some eigenstates of the Floquet operator whose imaginary parts of the quasienergy are significantly large. Above the transition point, the momentum current increases linearly with time. Interestingly, its acceleration rate exhibits a kind of "quantized" increment with the kicking strength. We propose a modified classical acceleration mode of the kicked rotor model to explain such an intriguing phenomenon. Our theoretical prediction is in good agreement with numerical results.

[Study on optimization of the hydrolysis process of dioscin catalyzed by hydrochloric acid].

OBJECTIVE: To study the optimization of hydrolysis process of dioscin catalyzed by hydrochloric acid. METHODS: The effects of hydrochloric acid concentration, reaction temperature, reaction time and their interactions had been investigated using orthogonal design and single-factor experiments. RESULTS: The optimum hydrolysis conditions were as follows: reaction temperature 90 degrees C, reaction time 3h, hydrochloric acid concentration 2.0 mol/L. CONCLUSION: Hydrochloric acid concentration and reaction temperature should be controlled because of their remarkable influence on hydrolysis process.

Suppressed Kondo effect and Kosterlitz-Thouless-type phase transition induced by level difference in a triple dot device.

Quantum dot system provides an ideal platform for quantum information processing, within which to demonstrate the quantum states is one of the most important issue for quantum simulation and quantum computation. In this paper, we report a peculiar electron state in a parallel triple dot device where the Ruderman-Kittel-Kasuya-Yosida interaction is invalid when the level differences of the dots sweep into appropriate regime. This extraordinary tendency then results in an antiferromagnetic spin coupling between two of the dots and may lead to zero or full conductance, relying deeply on the relation of the two level spacings. e.g. when the level differences are kept equal, the Kondo effect is totally suppressed although the dots are triply occupied, since in this case a local inter-dot transport loop is found to play an important role in the transmission coefficient. By contrast, when the differences are retained symmetric, the Kondo peak reaches nearly to its unitary limit, owing to that the inter-dot transport process is significantly suppressed. To approach these problems, voltage controllable quantum phase transitions of Kosterlitz-Thouless type and first order are shown, and possible pictures related to the many-body effect and the effective Kondo model are given.

Nonlinearity effects on the directed momentum current.

We investigate the quantum transport dynamics governed by the nonlinear Schrödinger equation with a periodically-δ-kicking potential and discover the emergence of a directed current in momentum space. With the increase of nonlinearity, we find strikingly that the momentum current decreases, reverses, and finally vanishes, indicating that the quantum transport can be effectively manipulated through adjusting the nonlinearity. The underlying dynamic mechanism is uncovered and some important implications are addressed.

Relationship between apolipoprotein E and apolipoprotein B polymorphisms in youths with coronary heart disease / 中华医学遗传学杂志

<p><b>OBJECTIVE</b>To investigate hereditary susceptibility to coronary heart disease (CHD) in apolipoprotein E(apo E) and apo B polymorphisms of youths.</p><p><b>METHODS</b>Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze apoE, apoB Xba I, apoB 3' variable number of tandem repeat (VNTR) genotypes for 244 healthy Han students (among them were 109 students with positive CHD family history).</p><p><b>RESULTS</b>The allele frequencies of apo e4, XbaI x(+), 3'VNTR-B(hypervariable element, HVE>38) in the positive group were obviously higher than those in the negative group(P<0.05), and were significantly correlated with the increase in TC, LDL-C, apoB100 levels (P<0.05).</p><p><b>CONCLUSION</b>The alleles for apo e4, XbaI x(+), 3'VNTR-B may be the important genetic markers of Han CHD.</p>