Detalhe da pesquisa
1.
Genome-wide analyses reveal the contribution of somatic variants to the immune landscape of multiple cancer types.
PLoS Genet
; 20(1): e1011134, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-38241355
2.
Fragment-Based Computational Method for Designing GPCR Ligands.
J Chem Inf Model
; 60(9): 4339-4349, 2020 09 28.
Artigo
Inglês
| MEDLINE | ID: mdl-31652060
3.
GPCR structure and function relationship: identification of a biased apelin receptor mutant.
Biochem J
; 475(23): 3813-3826, 2018 12 06.
Artigo
Inglês
| MEDLINE | ID: mdl-30409826
4.
Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious ß-secretase inhibitors for the potential treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 25(4): 767-74, 2015 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25613679
5.
A dual diffusion model enables 3D molecule generation and lead optimization based on target pockets.
Nat Commun
; 15(1): 2657, 2024 Mar 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38531837
6.
Cryo-EM structures reveal two allosteric inhibition modes of PI3KαH1047R involving a re-shaping of the activation loop.
Structure
; 2024 Mar 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38582077
7.
Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity.
Bioorg Med Chem Lett
; 23(15): 4459-64, 2013 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23769639
8.
Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design.
ACS Med Chem Lett
; 14(3): 297-304, 2023 Mar 09.
Artigo
Inglês
| MEDLINE | ID: mdl-36923916
9.
Establishing the relationship between in vitro potency, pharmacokinetic, and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived ß-secretase inhibitors.
J Pharmacol Exp Ther
; 343(2): 460-7, 2012 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-22911925
10.
Structure guided P1' modifications of HEA derived ß-secretase inhibitors for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 22(11): 3607-11, 2012 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22572583
11.
Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux.
Bioorg Med Chem Lett
; 22(24): 7371-5, 2012 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23149228
12.
Structural insights into ligand recognition and selectivity of somatostatin receptors.
Cell Res
; 32(8): 761-772, 2022 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35739238
13.
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor.
Nat Commun
; 12(1): 3763, 2021 06 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34145245
14.
Structure-guided discovery of a single-domain antibody agonist against human apelin receptor.
Sci Adv
; 6(3): eaax7379, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31998837
15.
Author Correction: Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism.
Cell Res
; 30(5): 455, 2020 May.
Artigo
Inglês
| MEDLINE | ID: mdl-32203135
16.
Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism.
Cell Res
; 30(5): 436-445, 2020 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32047270
17.
Stereoselective synthesis of anti-N-protected 3-amino-1,2-epoxides by nucleophilic addition to N-tert-butanesulfinyl imine of a glyceraldehyde synthon.
J Org Chem
; 74(16): 5975-82, 2009 Aug 21.
Artigo
Inglês
| MEDLINE | ID: mdl-19586010
18.
Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors.
Bioorg Med Chem Lett
; 19(23): 6591-4, 2009 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19864130
19.
Palladium-Promoted DNA-Compatible Heck Reaction.
Org Lett
; 21(3): 719-723, 2019 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30676761
20.
Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA.
Org Lett
; 20(22): 7186-7191, 2018 11 16.
Artigo
Inglês
| MEDLINE | ID: mdl-30365326