Construction of a digital anatomic atlas of the human globus pallidus internus in the standard stereotactic space / 中华神经医学杂志

Objective To construct a digital atlas of the globus pallidus internus (Gpi) in the standard stereotactic space using the sectional images of the male cadaver from "Atlas of Chinese Visible Human (Male and Female)". Methods Identification and segmentation of the Gpi,and anterior and posterior commissures from the sectional images were performed. We established the stereotactic coordinate system and reconstructed 3D models of the Gpi. Results Gpi looks like a bean according to the reconstructed models; Putamen and globus pallidus lateral (Gpe) were also constructed; and the location of the Gpi and the relation of Gpi with both Putamen and Gpe were shown in the stereotactic space. The lenticular nucleus could rotate and stretch at any angles in the standard stereotactic space.Conclusion It is feasible to reconstruct the 3D models of the subnucleus in the stereotactic space from the sectional image of the cadaver.

Studies on antitumor activity of rhEndostatin / 药学学报

<p><b>AIM</b>To investigate the inhibitory effect of recombinant human endostatin (rhEndostatin) on endothelia cell proliferation and tumor growth.</p><p><b>METHODS</b>MTT assay was applied to examine the anti-proliferation of rhEndostatin on human embryo umbilical cord vascular endothelial cell ECV304 and human cancer cell HCT-8, BGC803 and EJ. Xenotrasplanted nude mice models with human cancer and experimental implanted tumor mice model were used to evaluate rhEndostatin's antitumor activity.</p><p><b>RESULTS</b>rhEndostatin was shown to inhibit the proliferation of ECV304 cells and the IC50 is about 7 x 10(-6) g.L-1. No inhibition was observed in HCT-8, BGC803 and EJ cells at 1 x 10(-4) g.L-1 rhEndostatin. rhEndostatin was shown to inhibit human xenograft in nude mice with human gastric cancer BGC803 and breast cancer B37 when administered subcutaneously at 5, 10, 20 mg.kg-1.d-1 for 24 days in a dose-dependent manner. Mouse hepatoma H22 was also suppressed when given rhEndostatin subcutaneously 20 mg.kg-1.d-1 for 9 days, but it showed no inhibitory effect on Lewis lung carcinoma and B16 melanoma.</p><p><b>CONCLUSION</b>These results indicate that rhEndostatin can inhibit the growth of xenotransplanted human tumors in nude mice and certain murine tumor. The action mechanisms may be that it can inhibit endothelial cell proliferation, thereby inhibiting the formation of new blood vessel in tumor, leading the tumor to stop grow.</p>