1.
Chem Commun (Camb)
; 60(6): 694-697, 2024 Jan 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38105647
RESUMO
A nickel-catalyzed reductive tandem cyclization of the elaborated ß-bromo acetal with a dibenzoxepin scaffold was invented to strategically construct the remaining two rings in linoxepin. The generated diasterodivergent intermediates could be easily converted to both enantiomers of this unique cyclolignan molecule via facile oxidations, thus realizing enantiodivergent total synthesis of linoxepin for the first time.