Detalhe da pesquisa
1.
Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer's disease? From preclinical studies to the clinical trials.
Mol Psychiatry
; 28(6): 2197-2214, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-37264120
2.
Imaging Methods Applicable in the Diagnostics of Alzheimer's Disease, Considering the Involvement of Insulin Resistance.
Int J Mol Sci
; 24(4)2023 Feb 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36834741
3.
Annual Plasma Neurofilament Dynamics Is a Sensitive Biomarker of Disease Activity in Patients with Multiple Sclerosis.
Medicina (Kaunas)
; 59(5)2023 Apr 29.
Artigo
Inglês
| MEDLINE | ID: mdl-37241097
4.
Transcriptomic signature of Alzheimer's disease tau seed-induced pathology.
Gen Physiol Biophys
; 40(6): 541-549, 2021 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-34897025
5.
Neuropathology and biochemistry of early onset familial Alzheimer's disease caused by presenilin-1 missense mutation Thr116Asn.
J Neural Transm (Vienna)
; 125(6): 965-976, 2018 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29404783
6.
Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes.
Biochim Biophys Acta
; 1852(7): 1219-29, 2015 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-25772164
7.
Atypical Huntington's disease with the clinical presentation of behavioural variant of frontotemporal dementia.
J Neural Transm (Vienna)
; 123(12): 1423-1433, 2016 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27287334
8.
The manifold works of Prof. Michal Novak.
Gen Physiol Biophys
; 40(6): 439-442, 2021 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-34897019
9.
Microglia display modest phagocytic capacity for extracellular tau oligomers.
J Neuroinflammation
; 11: 161, 2014 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-25217135
10.
Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models.
Acta Neuropathol Commun
; 12(1): 52, 2024 Apr 04.
Artigo
Inglês
| MEDLINE | ID: mdl-38576010
11.
Efficacy assessment of an active tau immunotherapy in Alzheimer's disease patients with amyloid and tau pathology: a post hoc analysis of the "ADAMANT" randomised, placebo-controlled, double-blind, multi-centre, phase 2 clinical trial.
EBioMedicine
; 99: 104923, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-38101301
12.
Misfolded truncated protein τ induces innate immune response via MAPK pathway.
J Immunol
; 187(5): 2732-9, 2011 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21813771
13.
Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways.
J Neuroinflammation
; 9: 47, 2012 Mar 07.
Artigo
Inglês
| MEDLINE | ID: mdl-22397366
14.
The self-perpetuating tau truncation circle.
Biochem Soc Trans
; 40(4): 681-6, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22817716
15.
Immunomodulation of memory-impairing protein tau in Alzheimer's disease.
Neurodegener Dis
; 10(1-4): 242-5, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22433908
16.
Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy.
Front Aging Neurosci
; 14: 935973, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35966785
17.
Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern.
EBioMedicine
; 76: 103818, 2022 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-35078012
18.
Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models.
ACS Chem Neurosci
; 12(11): 1885-1893, 2021 06 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33689290
19.
ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer's disease.
Nat Aging
; 1(6): 521-534, 2021 06.
Artigo
Inglês
| MEDLINE | ID: mdl-37117834
20.
Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease.
J Neuroinflammation
; 7: 64, 2010 Oct 12.
Artigo
Inglês
| MEDLINE | ID: mdl-20937161