Intravenous clonidine in acute myocardial infarction in men.

We studied the effects of intravenous clonidine treatment in a group of 24 patients with acute myocardial transmural anterior and/or lateral wall infarction. Clonidine, known as an antihypertonic agent, was administered as a bolus of 1-2 micrograms/kg body weight and repeated every 2-3 hr. However, maximal range of the time interval was 20 min to 4 hr, maximal range of doses 37 to 150 micrograms, depending on the hemodynamic status. The effects were measured by precordial electrocardiographic mapping as well as serial creatine phosphokinase determinations. A big decrease in ST-segment elevation was observed: sigma ST reduction after 24 hr was 37% of initial value (140% in control group), after 48 hr - 30% (120% - control); NST fall after 24 hr - 45% (145% - control), after 48 hr - 41% (142% - control). NQ increased after 24 hr to 135% of initial value (156% - control), after 72 hr to 137% (167% - control). Detailed analysis revealed undoubted correlation between the dosage and favourable dynamics of precordial mapping parameters. Hemodynamic, antiarrhythmic and above all adrenolytic activity were noted. The treatment caused a distinct deterioration in daily adrenalinuria mean values to 5.99 micrograms in the first day (14.20 - control) and lower in the following days. No side effects were observed but sudden discontinuation of the therapy caused an unfavorable reaction. A temporal association between diminished adrenalinuria and both clinical improvement and limitation of infarct size was observed. Therapy with intravenous clonidine requires meticulous individualization of clonidine dosage depending on the patient's initial hemodynamic status.

[Effect of treatment with indobufen on blood viscosity indices and exercise tolerance in patients with coronary disease]. / Wplyw leczenia indobufenem na wskazniki lepkosci krwi i tolerancje wysilku fizycznego u chorych z choroba wiencowa.

The study included 20 patients aged from 50 to 65 years with stable coronary disease. In all patients exercise ECG test in Quinton moving track was performed before the treatment, and after one, three, and eight weeks of therapy. Besides that, before the treatment, and after each exercise, platelet aggregation, viscosity of whole blood and plasma, and filtration time of 1 ml of whole blood were evaluated. It was found that already after one week of treatment indobufen caused a decrease of platelet aggregation, reduction of viscosity of whole blood and plasma, and improvement of erythrocyte compliance which favourable effects increased with the continuation of the therapy up to eight weeks. At the same time as a result of eight weeks of treatment a significant improvement was achieved of exercise tolerance in the treated patients.

[Thrombi of the left ventricle, infarction location and method of treatment]. / Skrzepliny w lewej komorze a lokalizacja zawalu i sposób leczenia.

A study is reported of 63 patients treated in the Cardiology Department, Institute of Internal Diseases, MSW for acute myocardial infarction. They were divided into two groups: 21 patients w treated with intravenous streptokinase infusion and then with intravenous heparin, with simultaneous administration of nitroglycerin. The other group comprised 42 patients treated with nitroglycerin alone. On the basis of the mass of the infarcted tissue calculated from the curves of CK-MB levels, and echocardiography for assessment of the presence of left-ventricular clots and degree of impairment of cardiac wall contractility according to Heger a much more frequent occurrence was noted of clots in the left ventricle in patients treated with nitroglycerin only, but the volume of the infarcted tissue was not statistically significantly different between both groups.