Detalhe da pesquisa
1.
Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.
J Biol Chem
; 290(17): 11061-74, 2015 Apr 24.
Artigo
Inglês
| MEDLINE | ID: mdl-25762719
2.
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
J Med Chem
; 64(1): 677-694, 2021 01 14.
Artigo
Inglês
| MEDLINE | ID: mdl-33370104
3.
Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
J Med Chem
; 62(20): 8953-8972, 2019 10 24.
Artigo
Inglês
| MEDLINE | ID: mdl-31314518
4.
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
J Med Chem
; 62(20): 8973-8995, 2019 10 24.
Artigo
Inglês
| MEDLINE | ID: mdl-31318208
5.
Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.
ACS Med Chem Lett
; 10(3): 383-388, 2019 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-30891145
6.
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain.
Sci Transl Med
; 11(502)2019 07 24.
Artigo
Inglês
| MEDLINE | ID: mdl-31341059
7.
A comparative analysis of brain and plasma Abeta levels in eight common non-transgenic mouse strains: validation of a specific immunoassay for total rodent Abeta.
Curr Alzheimer Res
; 4(3): 297-303, 2007 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-17627487
8.
Unusual neuro-ophthalmologic findings in a patient with anti-Yo-associated cerebellar degeneration.
J Neurol Sci
; 225(1-2): 153-5, 2004 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-15465100