The need for a timely diagnostic workup for patients with venous leg ulcers.

OBJECTIVE: To explore the need for an extended diagnostic workup in patients with venous leg ulcers (VLUs) and to establish the prevalence of the underlying causes of VLU. METHOD: This retrospective cohort study analysed data from patients with VLU. The visual analogue scale (VAS) was used for pain assessment. The ankle-brachial index (ABI) was measured to exclude patients with arterial pathology. A duplex was performed. All patients received a wound treatment plan and ambulatory compression therapy. Continuous variables were presented as mean±standard deviation (SD) or median and interquartile range (IQR). Mann-Whitney U test and Kruskal-Wallis were used. When normally distributed, an independent sample t-test was used. RESULTS: A total of 70 patients were recruited. Of these, 18 (25.7%) experienced a VLU once and 52 (74.3%) had a recurrent VLU. Treatment of the underlying lesions was performed in almost 30% of patients. Patients who were treated showed almost two times slower healing rates compared with those who were not treated for an underlying pathology. The mean time in patient referral exceeded two years, and patients who did not see their GP were treated by nurses who did not provide regular feedback the GP; as a result, compression therapy was not always adequate. CONCLUSION: Patients with a VLU showing no signs of healing after 2 months should be referred to a dedicated wound care centre to avoid delays.

Prediction of venous wound healing with laser speckle imaging.

Introduction Laser speckle imaging is used for noninvasive assessment of blood flow of cutaneous wounds. The aim of this study was to assess if laser speckle imaging can be used as a predictor of venous ulcer healing. Methods After generating the flux speckle images, three regions of interest (ROI) were identified to measure the flow. Sensitivity, specificity, negative predictive value, and positive predictive value for ulcer healing were calculated. Results In total, 17 limbs were included. A sensitivity of 92.3%, specificity of 75.0%, PPV of 80.0%, and NPV 75.0% were found in predicting wound healing based on laser speckle images. Mean flux values were lowest in the center (ROI I) and showed an increase at the wound edge (ROI II, p = 0.03). Conclusion Laser speckle imaging shows acceptable sensitivity and specificity rates in predicting venous ulcer healing. The wound edge proved to be the best probability for the prediction of wound healing.

Contrast-enhanced duplex scanning of crural arteries by means of continuous infusion of Levovist.

OBJECTIVES: To estimate the dosage needed for continuous infusion and to investigate whether continuous infusion of the ultrasound contrast-enhancing agent Levovist (SH U 508A) can improve duplex scanning of crural arteries in patients with peripheral arterial obstructive disease (PAOD) eligible for distal bypass graft surgery. DESIGN, PATIENTS, AND METHODS: The study design consisted of two parts. Part 1 investigated the color and spectral Doppler scan enhancement of three different Levovist dosages (200, 300, and 400 mg/mL) in one arterial segment of a patent lumen of a crural artery in seven patients with PAOD. Part 2 investigated the value of the optimum Levovist dosage in the assessment of 10 crural arteries in 10 consecutive patients with PAOD. Angiography was the reference standard. RESULTS: Part 1: Levovist significantly enhanced color and spectral Doppler scan as compared with baseline ultrasound scan, but no differences were found between the Levovist dosages. Thus, the lowest Levovist dosage sufficed for application in part 2, because of its infusion volume and prolonged enhancement time. Part 2: The agreement between contrast-enhanced duplex scanning and angiography was moderate (kappa = 0.50; 95% confidence interval [CI], 0.03-0.97). Five (50%) of 10 crural arteries that could not adequately be visualized with routine duplex scanning could be visualized with contrast-enhanced duplex scanning. CONCLUSION: Contrast-enhanced duplex scanning by means of continuous infusion of Levovist in patients with PAOD improves the ultrasound scan investigation of crural arteries in case routine duplex scanning is inconclusive and might reduce the need for angiography.

Improved assessment of the hemodynamic significance of borderline iliac stenoses with use of hyperemic duplex scanning.

OBJECTIVE: To improve the assessment of the hemodynamic significance of borderline iliac stenoses (stenosis with a peak systolic velocity [PSV] ratio between 1.5 and 3.5) by means of hyperemic duplex scanning. The duplex ultrasound parameter-absolute increase in PSV across the stenosis after exercise (Delta PSV(e))-was studied prospectively. PATIENTS AND METHODS: Fifty-eight legs in 53 consecutive patients with symptomatic arterial obstructive disease with borderline iliac stenosis were studied prospectively. Ultrasound velocity data collected after exercise on a bicycle ergometer at 2 W/kg during 2 minutes were judged against the assessment of the hemodynamic significance by means of intraarterial pressure measurement, before and after the administration of 50 mg papaverine. RESULTS: On the basis of receiver operating characteristic curves traced for 43 iliac stenoses in 39 patients who finished the exercise, Delta PSV(e) > or = 1.4 m/s had optimal sensitivity of 93% (95% confidence interval [CI],.77-.99), specificity of 87% (95% CI,.60-.98), positive predictive value of 93% (95% CI,.77-.99) and negative predictive value of 87% (95% CI,.60-.98). CONCLUSIONS: The results of this study show that Delta PSV(e) with a cutoff value of 1.4 m/s in combination with the PSV ratio improves the assessment of the hemodynamic significance of borderline iliac artery stenoses if the patient can accomplish the workload.