Detalhe da pesquisa
1.
D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition.
Nat Chem Biol
; 16(6): 686-694, 2020 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32203411
2.
Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism.
Mol Microbiol
; 112(4): 1284-1307, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31389636
3.
Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification.
Mol Microbiol
; 111(4): 951-964, 2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30600561
4.
Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1.
Bioorg Med Chem
; 27(8): 1546-1561, 2019 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30837169
5.
The Mechanism of Acetyl Transfer Catalyzed by Mycobacterium tuberculosis GlmU.
Biochemistry
; 57(24): 3387-3401, 2018 06 19.
Artigo
Inglês
| MEDLINE | ID: mdl-29684272
6.
A novel regulatory factor affecting the transcription of methionine biosynthesis genes in Escherichia coli experiencing sustained nitrogen starvation.
Microbiology (Reading)
; 164(11): 1457-1470, 2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-29957170
7.
Protein CoAlation: a redox-linked post-translational modification.
Biochem J
; 474(16): 2897-2899, 2017 08 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28798160
8.
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.
Nature
; 480(7377): 379-82, 2011 Nov 06.
Artigo
Inglês
| MEDLINE | ID: mdl-22056990
9.
Glutamate Racemase Is the Primary Target of ß-Chloro-d-Alanine in Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 60(10): 6091-9, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27480853
10.
Metabolomic strategies for the identification of new enzyme functions and metabolic pathways.
EMBO Rep
; 15(6): 657-69, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-24829223
11.
Reinterpreting the mechanism of inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by D-cycloserine.
Biochemistry
; 52(40): 7145-9, 2013 Oct 08.
Artigo
Inglês
| MEDLINE | ID: mdl-24033232
12.
Metabolomic profiling reveals bacterial metabolic adaptation strategies and new metabolites.
Curr Opin Chem Biol
; 74: 102287, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-36948086
13.
Bottlenecks and opportunities in antibiotic discovery against Mycobacterium tuberculosis.
Curr Opin Microbiol
; 69: 102191, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35970040
14.
Metabolomic approaches for enzyme function and pathway discovery in bacteria.
Methods Enzymol
; 665: 29-47, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35379439
15.
A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).
Eur J Med Chem
; 230: 114105, 2022 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35065413
16.
On the chemical mechanism of succinic semialdehyde dehydrogenase (GabD1) from Mycobacterium tuberculosis.
Arch Biochem Biophys
; 509(1): 90-9, 2011 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21303655
17.
Correction to Reinterpreting the Mechanism of Inhibition of Mycobacterium tuberculosis d-Alanine:d-Alanine Ligase by d-Cycloserine.
Biochemistry
; 54(35): 8386, 2015 Sep 08.
Artigo
Inglês
| MEDLINE | ID: mdl-26539621
18.
Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite.
Mol Microbiol
; 71(3): 583-93, 2009 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-19040639
19.
A protecting group-free synthesis of deazathiamine: a step toward inhibitor design.
Bioorg Med Chem Lett
; 20(22): 6472-4, 2010 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20943392
20.
Kinetic evidence for interdomain communication in the allosteric regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis.
Biochemistry
; 48(9): 1996-2004, 2009 Mar 10.
Artigo
Inglês
| MEDLINE | ID: mdl-19166329