Detalhe da pesquisa
1.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell
; 184(24): 5886-5901.e22, 2021 11 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34822784
2.
Impact of GPCR Structures on Drug Discovery.
Cell
; 181(1): 81-91, 2020 04 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32243800
3.
Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3.
Mol Pharmacol
; 105(4): 301-312, 2024 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38346795
4.
Predicting the target landscape of kinase inhibitors using 3D convolutional neural networks.
PLoS Comput Biol
; 19(9): e1011301, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37669273
5.
Structure-Based Virtual Screening for Ligands of G Protein-Coupled Receptors: What Can Molecular Docking Do for You?
Pharmacol Rev
; 73(4): 527-565, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34907092
6.
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Nature
; 546(7657): 312-315, 2017 06 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28514449
7.
Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature
; 546(7657): 259-264, 2017 06 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28514451
8.
KLIFS: an overhaul after the first 5 years of supporting kinase research.
Nucleic Acids Res
; 49(D1): D562-D569, 2021 01 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33084889
9.
Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists.
Proc Natl Acad Sci U S A
; 117(46): 29144-29154, 2020 11 17.
Artigo
Inglês
| MEDLINE | ID: mdl-33148803
10.
SAR exploration of the non-imidazole histamine H3 receptor ligand ZEL-H16 reveals potent inverse agonism.
Arch Pharm (Weinheim)
; 356(1): e2200451, 2023 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-36310109
11.
Classification Model for the Second Extracellular Loop of Class A GPCRs.
J Chem Inf Model
; 62(3): 511-522, 2022 02 14.
Artigo
Inglês
| MEDLINE | ID: mdl-35113559
12.
Extending the Structural View of Class B GPCRs.
Trends Biochem Sci
; 42(12): 946-960, 2017 12.
Artigo
Inglês
| MEDLINE | ID: mdl-29132948
13.
Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule.
Bioorg Chem
; 111: 104832, 2021 06.
Artigo
Inglês
| MEDLINE | ID: mdl-33826962
14.
X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A2A Adenosine Receptor Antagonists.
Angew Chem Int Ed Engl
; 59(38): 16536-16543, 2020 09 14.
Artigo
Inglês
| MEDLINE | ID: mdl-32542862
15.
Chemokine Receptor Crystal Structures: What Can Be Learned from Them?
Mol Pharmacol
; 96(6): 765-777, 2019 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31266800
16.
Modulators of CXCR4 and CXCR7/ACKR3 Function.
Mol Pharmacol
; 96(6): 737-752, 2019 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31548340
17.
Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design.
Bioorg Med Chem Lett
; 29(20): 126611, 2019 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31447084
18.
Understanding Ligand Binding Selectivity in a Prototypical GPCR Family.
J Chem Inf Model
; 59(6): 2830-2836, 2019 06 24.
Artigo
Inglês
| MEDLINE | ID: mdl-31125224
19.
Structure of the human glucagon class B G-protein-coupled receptor.
Nature
; 499(7459): 444-9, 2013 Jul 25.
Artigo
Inglês
| MEDLINE | ID: mdl-23863937
20.
Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology.
J Am Chem Soc
; 140(12): 4232-4243, 2018 03 28.
Artigo
Inglês
| MEDLINE | ID: mdl-29470065