Detalhe da pesquisa
1.
Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP.
Invest New Drugs
; 30(2): 443-9, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-20963470
2.
Tumor microvasculature supports proliferation and expansion of glioma-propagating cells.
Int J Cancer
; 125(5): 1222-30, 2009 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19431144
3.
Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice.
Mol Cancer Ther
; 7(8): 2280-7, 2008 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-18723475
4.
P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan.
Clin Cancer Res
; 13(21): 6440-9, 2007 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17975156
5.
Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2.
Neoplasia
; 20(7): 710-720, 2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29852323
6.
Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression.
Cell Rep
; 10(3): 383-397, 2015 Jan 20.
Artigo
Inglês
| MEDLINE | ID: mdl-25600873
7.
Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies.
Clin Cancer Res
; 16(13): 3431-41, 2010 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20472681
8.
High-grade glioma mouse models and their applicability for preclinical testing.
Cancer Treat Rev
; 35(8): 714-23, 2009 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-19767151
9.
Determination of topotecan in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography.
Biomed Chromatogr
; 21(11): 1191-200, 2007 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-17582233
10.
Blood-brain barrier and chemotherapeutic treatment of brain tumors.
Expert Rev Neurother
; 6(8): 1199-209, 2006 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-16893347