Detalhe da pesquisa
1.
Pharmacokinetics, safety, and tolerability of fosmanogepix IV to oral switch and multiple IV doses in healthy participants.
Antimicrob Agents Chemother
; 68(5): e0145523, 2024 May 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38551346
2.
Safety and Pharmacokinetics of Intravenous and Oral Fosmanogepix, a First-in-Class Antifungal Agent, in Healthy Volunteers.
Antimicrob Agents Chemother
; 67(4): e0162322, 2023 04 18.
Artigo
Inglês
| MEDLINE | ID: mdl-36988461
3.
Rethinking, reducing, and refining the classical oral tyramine challenge test of monoamine oxidase (MAO) inhibitors.
Clin Transl Sci
; 16(10): 2058-2069, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37596819
4.
Predictability of Elimination and Excretion of Small Molecules in Animals and Humans, and its Impact on Dosimetry for human ADME Studies with Radiolabeled Drugs.
Curr Rev Clin Exp Pharmacol
; 17(1): 26-38, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-33687900
5.
Pharmacology-Guided Rule-Based Adaptive Dose Escalation in First-in-Human Studies.
Clin Pharmacol Ther
; 109(5): 1326-1333, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33150581
6.
First-in-Human Study of the Safety, Tolerability, Pharmacokinetics and - Preliminary Dynamics of Neuroprotectant 2-Iminobiotin in Healthy Subjects.
Curr Clin Pharmacol
; 15(2): 152-163, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-31625480
7.
Science-based Ethnic Bridging in Drug Development; Review of Recent Precedence and Suggested Steps Forward.
Curr Clin Pharmacol
; 14(3): 197-207, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-30961506
8.
Disproportional inflation of clinical trial costs: why we should care, and what we should do about it.
Nat Rev Drug Discov
; 23(2): 85-86, 2024 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38195708
9.
Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion.
Sci Transl Med
; 9(387)2017 04 26.
Artigo
Inglês
| MEDLINE | ID: mdl-28446688
10.
Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers.
Br J Clin Pharmacol
; 63(5): 562-74, 2007 May.
Artigo
Inglês
| MEDLINE | ID: mdl-17488363
11.
Renal glucose excretion as a function of blood glucose concentration in subjects with type 2 diabetes--results of a hyperglycaemic glucose clamp study.
Nephrol Dial Transplant
; 21(8): 2166-71, 2006 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-16627603