Neural Representation of Donating Time and Money.

Volunteering and charitable donations are two common forms of prosocial behavior, yet it is unclear whether these other-benefitting behaviors are supported by the same or different neurobiological mechanisms. During an fMRI task, 40 participants (20 female-identifying; age: mean = 18.92 years, range = 18.32-19.92 years) contributed their time (in minutes) and money (in dollars) to a variety of local charities. With the maximum amount of time and money that participants could spend on these charities, they did not differentially donate their time and money. At the neural level, donating time and money both showed activations in brain regions involved in cognitive control (e.g., dorsolateral PFC) and affective processing (e.g., dorsal anterior cingulate cortex), but donating time recruited regions involved in reward valuation (e.g., ventral striatum) and mentalizing (e.g., temporal pole) to a greater extent than donating money. Further, the precuneus, which is also a region involved in mentalizing, more strongly tracked the varying amount of money than time donated, suggesting that the precuneus may be more sensitive to the increasing magnitude of a nonsocial exchange (e.g., donating money is a financial exchange) than a social exchange (e.g., donating time is an interpersonal exchange). Our findings elucidate shared as well as distinct neurobiological properties of two prosocial behaviors, which have implications for how humans share different resources to positively impact their community.SIGNIFICANCE STATEMENT Prosocial behaviors broadly characterize how humans act to benefit others. Various prosocial behaviors, such as volunteering and charitable donations, share the goal of positively contributing to community. Our study identifies brain regions that may serve as ubiquitous neurobiological markers of community-based prosocial behaviors. Despite this shared goal, our study also shows that the human brain responds to donating time and money in diverging ways, such that brain regions associated with processing emotional reward and thinking about others are more strongly recruited for donating time than for money. Therefore, our study sheds light on how different personal resources, such as one's time and money, within a prosocial context are represented in the brain.

Parental Support and Positive Mood Buffer Adolescents' Academic Motivation During the COVID-19 Pandemic.

School closures during the first COVID-19 lockdown in 2020 severely disrupted adolescents' lives. We used a daily diary method for 20 days, including online and physical school days, assessing daily mood, social support and conflict, and academic motivation in 102 adolescents aged 12-16 years. We found that adolescents' academic motivation was lower on online compared with physical school days. In general, positive mood was positively associated with academic motivation, and friend conflict related negatively to academic motivation. Moreover, lower levels of parental support were related to lower academic motivation on online versus physical school days. Overall, these findings identified some critical changes in adolescents' daily experiences during the COVID-19 school closure and social-emotional factors that may buffer decreases in adolescents' academic motivation.

Differential Behavioral and Neural Profiles in Youth With Conduct Problems During Risky Decision-Making.

Neuroimaging work has examined neural processes underlying risk taking in adolescence, yet predominantly in low-risk youth. To determine whether we can extrapolate from current neurobiological models, this functional magnetic resonance imaging study investigated risk taking and peer effects in youth with conduct problems (CP; N = 19) and typically developing youth (TD; N = 25). Results revealed higher real-life risk taking, lower risky decisions, and no peer effects on a risk-taking task in CP youth. CP youth showed greater ventral striatum (VS) activity during safe than risky decisions, whereas TD youth showed greater VS activation during risky decisions. Differential VS activity explained higher real-life risk taking in CP youth. Findings provide preliminary evidence that risk-taking behavior in youth with CD problems is characterized by differential neural patterns.

Turning a Blind Eye? Punishment of Friends and Unfamiliar Peers After Observed Exclusion in Adolescence.

In order to decrease the occurrence of social exclusion in adolescence, we need to better understand how adolescents perceive and behave toward peers involved in exclusion. We examined the role of friendships in treatment of perpetrators and victims of social exclusion. Eighty-nine participants (aged 9-16) observed exclusion of an unfamiliar peer (victim) by their best friend and another unfamiliar peer. Subsequently, participants could give up valuable coins to altruistically punish or help peers. Results showed that participants altruistically compensated victims and punished unfamiliar excluders, but refrained from punishing their friends. Our findings show that friendship with excluders modulates altruistic punishment of peers and provide mechanistic insight into how friendships may influence treatment of peers involved in social exclusion during adolescence.

Hanging Out With the Right Crowd: Peer Influence on Risk-Taking Behavior in Adolescence.

Peer influence plays a key role in the increase of risk-taking behavior during adolescence. However, its underlying processes are not fully understood. This study examined the effects of social norms, conveyed through peer advice, on risk-taking behavior in 15- to 17-year-old adolescents (N = 76). Participants played a card-guessing task alone and with online peer advice. Results showed that risk-taking increased in the presence of peers. The results further showed that adolescents took into account the uncertainty associated with gambles, as well as the social norms conveyed by peers. Our findings suggest that peers are most influential in uncertain situations and demonstrate the value of a social norms approach in examining the processes underlying peer effects.

Age-related changes in ventrolateral prefrontal cortex activation are associated with daily prosocial behaviors two years later.

As adolescents acquire agency and become contributing members of society, it is necessary to understand how they help their community. Yet, it is unknown how prosocial behavior develops in the context of community-based prosocial behaviors that are relevant to adolescents, such as donating time to charities. In this longitudinal functional magnetic resonance imaging study, adolescents (N=172; mean age at wave 1=12.8) completed a prosocial task annually for three years (N=422 and 375 total behavioral and neural data points, respectively), and 14 days of daily diaries reporting on their prosocial behaviors two years later. During the task, adolescents decided how many minutes they would donate to a variety of local charities. We found that adolescents donated less time to charities from early to mid adolescence. Longitudinal whole-brain analyses revealed declines in ventrolateral prefrontal cortex (vlPFC) activation, as well as inverted U-shaped changes in precuneus activation when adolescents donated their time from early to mid adolescence. A less steep decrease in vlPFC activation predicted greater real-life prosocial behaviors in youth's daily lives two years later. Our study elucidates the neurodevelopmental mechanisms of prosocial behavior from early to mid adolescence that have enduring effects on daily prosocial behaviors in late adolescence.

Neural processing of observed performance-based errors and rewards in the context of friends and unfamiliar peers across adolescence.

Adolescence is characterized by changes in performance monitoring, whereby action outcomes are monitored to subsequently adapt behavior and optimize performance. Observation of performance-based outcomes (i.e., errors and rewards) received by others forms the basis of observational learning. Adolescence is also a period of increasing importance of peers, especially friends, and observing peers forms a crucial aspect of learning in the social context of the classroom. However, to our knowledge, no developmental fMRI studies have examined the neural mechanisms underlying observed performance monitoring of errors and rewards in the context of peers. The current fMRI study investigated the neural correlates of observing performance-based errors and rewards of peers in adolescents aged 9-16 years (N = 80). In the scanner, participants observed either their best friend or an unfamiliar peer play a shooting game resulting in performance-dependent rewards (based on hits) or losses (based on misses, i. e, errors), where outcomes affected both the player and the observing participant. Findings showed higher activation in the bilateral striatum and bilateral anterior insula when adolescents observed peers (i.e., best friend and unfamiliar peer) receive performance-based rewards compared to losses. This might reflect the heightened salience of observed reward processing in the peer context in adolescence. Our results further revealed lower activation in the left temporoparietal junction (TPJ) while adolescents observed the performance-based outcomes (rewards and losses) for their best friend than for an unfamiliar peer. Considering that observation of others' performance-based errors and rewards forms the basis of observational learning, this study provides a crucial first step in understanding and potentially improving adolescent observational learning in the peer context.

Susceptibility to peer influence on prosocial behavior in adolescents with Mild Intellectual Disability or Borderline Intellectual Functioning.

BACKGROUND: Adolescents with Mild Intellectual Disability (MID) or Borderline Intellectual Functioning (BIF) are highly susceptible to negative peer influence. However, research in typically developing adolescents shows that peers can also promote prosocial behavior, which is an opportunity for positive development. AIMS: The current study aimed to investigate the effect of peer influence on prosocial behavior in adolescents with MID or BIF. METHODS AND PROCEDURES: In an experimental donation task, 40 adolescents with MID or BIF (Mage = 14.0, 40 % boys) were repeatedly asked how many of five coins they would like to donate to the group. The task had four consecutive within-subject conditions: alone, with virtual peers present, with virtual peer feedback, and alone again. OUTCOMES AND RESULTS: Results showed that adolescents made larger donations with virtual peers present, and even larger with peer feedback. This increase in donations sustained for subsequent decisions made alone. Finally, adolescents with BIF made larger donations with peer feedback compared to adolescents with MID. CONCLUSIONS AND IMPLICATIONS: Adolescents with MID or BIF are susceptible to peer influence on prosocial behavior, demonstrating the potential effect social context can have on promoting positive development.

Understanding Problematic Social Media Use in Adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD): A Narrative Review and Clinical Recommendations.

Attention-Deficit/Hyperactivity Disorder (ADHD) is consistently associated with a host of social problems, such as victimization and difficulties in maintaining close friendships. These problems are not limited to offline relations but also manifest in the online social world, as previous research shows that ADHD is associated with problematic use of social media. Given the ubiquitous nature of social media, the goal of the current review is to understand why adolescents with ADHD demonstrate more problematic social media use than their typically developing peers. To this end, we provide a narrative review on the evidence for the link between ADHD and social media use, and consequently present an integrative framework, which encompasses neurobiological mechanisms (i.e., imbalance theory of brain development and dual pathway model of ADHD) and social mechanisms, including influences from peers and parents. We conclude that empirical work shows most consistent evidence for the link between problematic social media use and ADHD (symptoms), while intensity of social media use is also associated with several other behaviors and outcomes. Finally, we hypothesize how existing interventions for ADHD may work on the identified mechanisms and provide at-hand clinical recommendations for therapists working with adolescents with ADHD who exhibit problematic social media use.

Risks and rewards in adolescent decision-making.

Adolescent decision-making has been characterized as risky, and a heightened reward sensitivity may be one of the aspects contributing to riskier choice-behavior. Previous studies have targeted reward-sensitivity in adolescence and the neurobiological mechanisms of reward processing in the adolescent brain. In recent examples, researchers aim to disentangle the contributions of risk- and reward-sensitivity to adolescent risk-taking. Here, we discuss recent findings of adolescent's risk preferences and the associated neural mechanisms. We highlight potential frameworks that target individual differences in risk preferences in an effort to understand adolescent risk-taking, and with an ultimate goal of leveraging undesirable levels of risk taking.

Understanding the Dynamics of the Developing Adolescent Brain Through Team Science.

One of the major goals for research on adolescent development is to identify the optimal conditions for adolescents to grow up in a complex social world and to understand individual differences in these trajectories. Based on influential theoretical and empirical work in this field, achieving this goal requires a detailed understanding of the social context in which neural and behavioral development takes place, along with longitudinal measurements at multiple levels (e.g., genetic, hormonal, neural, behavioral). In this perspectives article, we highlight the promising role of team science in achieving this goal. To illustrate our point, we describe meso (peer relations) and micro (social learning) approaches to understand social development in adolescence as crucial aspects of adolescent mental health. Finally, we provide an overview of how our team has extended our collaborations beyond scientific partners to multiple societal partners for the purpose of informing and including policymakers, education and health professionals, as well as adolescents themselves when conducting and communicating research.

Peer feedback decreases impulsive choice in adolescents with and without attention-deficit/hyperactivity disorder.

Background: Impulsivity is a core feature of attention-deficit/hyperactivity disorder (ADHD). Previous work using the delay discounting task to assess impulsivity reveals that adolescents with ADHD tend to prefer a smaller-immediate reward over a larger-delayed reward, and this relates to problematic choices in daily life. To gain a better understanding of daily decision-making in adolescence, it is important to examine the social context, as peers have a major influence on decisions. Peer influence often has a negative connotation, but also provides an opportunity to promote positive outcomes. To date, it is unclear if peers affect impulsive decision-making in adolescents with ADHD, for better or for worse. Methods: The aim of this preregistered study was to examine the effect of peer feedback on impulsive choice in male adolescents with and without ADHD (ages 13-23; N = 113). We utilized an adapted delay discounting task that was administered alone, in a social condition, and alone again. In the social condition, adolescents received either (between-subjects) manipulated impulsive or non-impulsive peer feedback. Impulsive peer feedback consisted of likes for choosing the smaller immediate reward, whereas non-impulsive peers endorsed choosing the larger delayed reward. Results: Preregistered analyses showed that non-impulsive peer feedback resulted in decreased impulsive choice, whereas impulsive peer feedback did not alter decision-making in adolescents with and without ADHD. Explorative analyses of inattention and hyperactivity-impulsivity symptoms in the total sample, irrespective of diagnosis, showed that lower hyperactivity-impulsivity and more inattention symptoms were associated with increased susceptibility to non-impulsive peer feedback. Conclusions: Together, these findings indicate that peers may provide an opportunity to decrease impulsivity and emphasize individual differences in susceptibility to non-impulsive peer feedback related to inattention and hyperactivity-impulsivity. Therefore, peer feedback may be a promising component in behavioral peer-supported interventions in adolescents with ADHD.

Hormonal and neural correlates of prosocial conformity in adolescents.

The dual hormone hypothesis, which centers on the interaction between testosterone and cortisol on social behavior, offers a compelling framework for examining the role of hormones on the neural correlates of adolescent peer conformity. Expanding on this hypothesis, the present study explored the interaction between testosterone and cortisol via hair concentrations on adolescents' conformity to peers. During fMRI, 136 adolescents (51 % female) ages 11-14 years (M = 12.32; SD = 0.6) completed a prosocial decision-making task. Participants chose how much of their time to donate to charity before and after observing a low- or high-prosocial peer. Conformity was measured as change in behavior pre- to post-observation. High testosterone with low cortisol was associated with greater conformity to high-prosocial peers but not low prosocial peers. Focusing on high prosocial peers, whole-brain analyses indicated greater activation post- vs. pre-observation as a function of high testosterone and low cortisol in regions implicated in social cognition, salience detection, and reward processing: pSTS/TPJ, insula, OFC, and caudate nucleus. Results highlight the relevance of hormones for understanding the neural correlates of adolescents' conformity to prosocial peers.

Age and Gender Effects in Sensitivity to Social Rewards in Adolescents and Young Adults.

Adolescence is a sensitive period for socio-cultural processing and a vast literature has established that adolescents are exceptionally attuned to the social context. Theoretical accounts posit that the social reward of social interactions plays a large role in adolescent sensitivity to the social context. Yet, to date it is unclear how sensitivity to social reward develops across adolescence and young adulthood and whether there are gender differences. The present cross-sectional study (N = 271 participants, age 11-28 years) examined age and gender effects in self-reported sensitivity to different types of social rewards. In order to achieve this aim, the Dutch Social Reward Questionnaire for Adolescents was validated. Findings revealed that each type of social reward was characterized by distinct age and gender effects. Feeling rewarded by gaining positive attention from others showed a peak in late adolescence, while enjoying positive reciprocal relationships with others showed a linear increase with age. Enjoying cruel behavior toward others decreased with age for girls, while boys showed no changes with age and reported higher levels across ages. Reward from giving others control showed a mid-adolescent dip, while enjoying group interactions did not show any changes with age. Taken together, the results imply that the social reward of social interactions is a nuanced and complex construct, which encompasses multiple components that show unique effects with age and gender. These findings enable us to gain further traction on the ubiquitous effects of the social context on decision-making in adolescent's lives.

Incorporating the social context into neurocognitive models of adolescent decision-making: A neuroimaging meta-analysis.

Neurobiological models of adolescent decision-making emphasize developmental changes in brain regions involved in affect (e.g., ventral striatum) and cognitive control (e.g., lateral prefrontal cortex). Although social context plays an important role in adolescent decision-making, current models do not discuss brain regions implicated in processing social information (e.g., dorsomedial prefrontal cortex). We conducted a coordinate-based meta-analysis using the Multilevel peak Kernel Density Analysis (MKDA) method to test the hypothesis that brain regions involved in affect, cognitive control, and social information processing support adolescent decision-making in social contexts (N = 21 functional neuroimaging studies; N = 1292 participants). Results indicated that dorsomedial prefrontal cortex, inferior frontal gyrus/insula and ventral striatum are consistently associated with adolescent decision-making in social contexts. Activity within these regions was modulated by the type of social context and social actors involved. Findings suggest including brain regions involved in social information processing into models of adolescent decision-making. We propose a 'constructionist' model, which describes psychological processes and corresponding neural networks related to affect, cognitive control, and social information processing.

Moderate social sensitivity in a risky context supports adaptive decision making in adolescence: evidence from brain and behavior.

Adolescence is a time of increased social-affective sensitivity, which is often related to heightened health-risk behaviors. However, moderate levels of social sensitivity, relative to either low (social vacuum) or high levels (exceptionally attuned), may confer benefits as it facilitates effective navigation of the social world. The present fMRI study tested a curvilinear relationship between social sensitivity and adaptive decision-making. Participants (ages 12-16; N = 35) played the Social Analogue Risk Task, which measures participants' willingness to knock on doors in order to earn points. With each knock, the facial expression of the house's resident shifted from happy to somewhat angrier. If the resident became too angry, the door slammed and participants lost points. Social sensitivity was defined as the extent to which adolescents adjusted their risky choices based on shifting facial expressions. Results confirmed a curvilinear relationship between social sensitivity and self-reported adaptive decision-making at the behavioral and neural level. Moderate adolescent social sensitivity was modulated via heightened tracking of social cues in the temporoparietal junction, insula and dorsolateral prefrontal cortex and related to adaptive decision-making. These findings suggest that social-affective sensitivity may positively impact outcomes in adolescence and have implications for interventions to help adolescents reach mature social goals into adulthood.

Social Influence on Positive Youth Development: A Developmental Neuroscience Perspective.

Susceptibility to social influence is associated with a host of negative outcomes during adolescence. However, emerging evidence implicates the role of peers and parents in adolescents' positive and adaptive adjustment. Hence, in this chapter we highlight social influence as an opportunity for promoting social adjustment, which can redirect negative trajectories and help adolescents thrive. We discuss influential models about the processes underlying social influence, with a particular emphasis on internalizing social norms, embedded in social learning and social identity theory. We link this behavioral work to developmental social neuroscience research, rooted in neurobiological models of decision making and social cognition. Work from this perspective suggests that the adolescent brain is highly malleable and particularly oriented toward the social world, which may account for heightened susceptibility to social influences during this developmental period. This chapter underscores the need to leverage social influences during adolescence, even beyond the family and peer context, to promote positive developmental outcomes. By further probing the underlying neural mechanisms as an additional layer to examining social influence on positive youth development, we will be able to gain traction on our understanding of this complex phenomenon.

Functional connectivity in the social brain across childhood and adolescence.

Previous research has characterized a collection of neural regions which support social-cognitive processes. While this 'social brain' is often described as a cohesive unit, it has been largely assessed with univariate methodologies, which cannot account for functional relationships 'between' brain regions, and therefore cannot test the idea of the social brain as a network. In the present work, we utilized a multi-method approach to empirically assess the functional architecture of the social brain. Fifty participants (ages 8-16) completed a social evaluation task during an functional imaging scan. Results from three unique functional connectivity methodologies demonstrated that social brain regions show strong functional relationships, while also interfacing with non-social regions, suggesting that future work should consider network relationships between social brain regions in addition to traditional univariate approaches. We probed, but did not find age-related differences in social brain network organization, demonstrating that this functional architecture is in place by late childhood.

Neural correlates of sibling closeness and association with externalizing behavior in adolescence.

Sibling relationships have been linked to adolescent externalizing behaviors, but the neurobiological factors that underlie this association have not been identified. This study investigated sibling closeness and birth order as a predictor of adolescent externalizing behavior via differences in neural processes during safe decision-making. A total of 77 adolescents (range = 12-15 years, Mage = 13.45 years, 40 females) completed a computerized driving task during a functional MRI scan. Results showed that adolescents' perceptions of sibling closeness were associated with greater neural activation in the anterior insula, ventral striatum and left ventrolateral prefrontal cortex when making safe decisions, suggesting that the quality of sibling relationships modulates adolescent neurocognition even without being present. Furthermore, moderated mediation analyses revealed that higher sibling closeness was associated with lower externalizing behavior via left anterior insula activation during safe decision-making, but only for adolescents without older siblings (i.e. eldest children) compared to adolescents who had multiple older siblings. Importantly, these findings persisted above and beyond parental and peer closeness and sibling characteristics (i.e. sex, relatedness, birth order), highlighting the significant influence of sibling relationships on adolescent externalizing behavior through the brain.

Differential effects of parent and peer presence on neural correlates of risk taking in adolescence.

Adolescence is a developmental period associated with increased health-risk behaviors and unique sensitivity to the input from the social context, paralleled by major changes in the developing brain. Peer presence increases adolescent risk taking, associated with greater reward-related activity, while parental presence decreases risk taking, associated with decreased reward-related activity and increased cognitive control. Yet the effects specific to peers and parents are still unknown. The current functional magnetic resonance imaging (fMRI) study compared within-person peer and parent influences on risky decision-making during adolescence (ages 12-15 years; N = 56). Participants completed the Yellow Light Game (YLG), a computerized driving task, during which they could make safe or risky decisions, in the presence of a peer and their parent. Behavioral findings revealed no effects of social context on risk taking. At the neural level, a collection of affective, social and cognitive regions [ventral striatum (VS), temporo-parietal junction (TPJ), and dorsolateral prefrontal cortex (dlPFC)] was more active during decision-making with peers than parents. Additionally, functional connectivity analyses showed greater coupling between affective, social and cognitive control regions (VS-insula, VS-TPJ) during decision-making with parents than peers. These findings highlight the complex nature of social influence processes in peer and parent contexts, and contribute to our understanding of the opportunities and vulnerabilities associated with adolescent social sensitivity.